Combination of Gold Nanoparticles with Carnitine Attenuates Brain Damage in an Obesity Animal Model.

التفاصيل البيبلوغرافية
العنوان:	Combination of Gold Nanoparticles with Carnitine Attenuates Brain Damage in an Obesity Animal Model.
المؤلفون:	da Silva LE; Laboratory of Neurobiology of Inflammatory and Metabolic Processes, Graduate Program in Health Sciences, Universidade Do Sul de Santa Catarina, Av. José Acácio Moreira, 787, Tubarão, Santa Catarina, SC, 88704-900, Brazil. larissa_espindola@outlook.com., Abel JS; Laboratory of Neurobiology of Inflammatory and Metabolic Processes, Graduate Program in Health Sciences, Universidade Do Sul de Santa Catarina, Av. José Acácio Moreira, 787, Tubarão, Santa Catarina, SC, 88704-900, Brazil., Tartari G; Laboratory of Neurobiology of Inflammatory and Metabolic Processes, Graduate Program in Health Sciences, Universidade Do Sul de Santa Catarina, Av. José Acácio Moreira, 787, Tubarão, Santa Catarina, SC, 88704-900, Brazil., da Silva MR; Laboratory of Neurobiology of Inflammatory and Metabolic Processes, Graduate Program in Health Sciences, Universidade Do Sul de Santa Catarina, Av. José Acácio Moreira, 787, Tubarão, Santa Catarina, SC, 88704-900, Brazil., de Oliveira MP; Laboratory of Neurobiology of Inflammatory and Metabolic Processes, Graduate Program in Health Sciences, Universidade Do Sul de Santa Catarina, Av. José Acácio Moreira, 787, Tubarão, Santa Catarina, SC, 88704-900, Brazil., Vedova LMD; Laboratory of Neurobiology of Inflammatory and Metabolic Processes, Graduate Program in Health Sciences, Universidade Do Sul de Santa Catarina, Av. José Acácio Moreira, 787, Tubarão, Santa Catarina, SC, 88704-900, Brazil., Mendes TF; Laboratory of Neurobiology of Inflammatory and Metabolic Processes, Graduate Program in Health Sciences, Universidade Do Sul de Santa Catarina, Av. José Acácio Moreira, 787, Tubarão, Santa Catarina, SC, 88704-900, Brazil., Mendes RL; Laboratory of Neurobiology of Inflammatory and Metabolic Processes, Graduate Program in Health Sciences, Universidade Do Sul de Santa Catarina, Av. José Acácio Moreira, 787, Tubarão, Santa Catarina, SC, 88704-900, Brazil., Soares HJ; Laboratory of Neurobiology of Inflammatory and Metabolic Processes, Graduate Program in Health Sciences, Universidade Do Sul de Santa Catarina, Av. José Acácio Moreira, 787, Tubarão, Santa Catarina, SC, 88704-900, Brazil., Vernke CN; Laboratory of Neurobiology of Inflammatory and Metabolic Processes, Graduate Program in Health Sciences, Universidade Do Sul de Santa Catarina, Av. José Acácio Moreira, 787, Tubarão, Santa Catarina, SC, 88704-900, Brazil., Zaccaron RP; Laboratory of Neurobiology of Inflammatory and Metabolic Processes, Graduate Program in Health Sciences, Universidade Do Sul de Santa Catarina, Av. José Acácio Moreira, 787, Tubarão, Santa Catarina, SC, 88704-900, Brazil., Lemos IS; Laboratory of Neurometabolic Diseases, Graduate Program in Health Sciences, Universidade Do Extremo Sul Catarinense, Criciuma, SC, Brazil., Petronilho F; Laboratory of Experimental Neurology, Graduate Program in Health Sciences, Universidade Do Extremo Sul Catarinense, Criciuma, SC, Brazil., Silveira PCL; Pathophysiology Laboratory, Graduate Program in Health Sciences, Universidade Do Extremo Sul Catarinense, Criciuma, SC, Brazil., Streck EL; Laboratory of Neurometabolic Diseases, Graduate Program in Health Sciences, Universidade Do Extremo Sul Catarinense, Criciuma, SC, Brazil., de Ávila RAM; Pathophysiology Laboratory, Graduate Program in Health Sciences, Universidade Do Extremo Sul Catarinense, Criciuma, SC, Brazil., de Mello AH; Department of Pediatrics, The University of Texas Medical Branch, Galveston, TX, USA., Rezin GT; Laboratory of Neurobiology of Inflammatory and Metabolic Processes, Graduate Program in Health Sciences, Universidade Do Sul de Santa Catarina, Av. José Acácio Moreira, 787, Tubarão, Santa Catarina, SC, 88704-900, Brazil.
المصدر:	Molecular neurobiology [Mol Neurobiol] 2024 Sep; Vol. 61 (9), pp. 6366-6382. Date of Electronic Publication: 2024 Feb 01.
نوع المنشور:	Journal Article
اللغة:	English
بيانات الدورية:	Publisher: Humana Press Country of Publication: United States NLM ID: 8900963 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-1182 (Electronic) Linking ISSN: 08937648 NLM ISO Abbreviation: Mol Neurobiol Subsets: MEDLINE
أسماء مطبوعة:	Original Publication: Clifton, NJ : Humana Press, c1987-
مواضيع طبية MeSH:	Carnitine/pharmacology , Carnitine/administration & dosage , Carnitine/therapeutic use , Metal Nanoparticles , Gold/pharmacology , Obesity/drug therapy , Obesity/pathology , Obesity/complications , Disease Models, Animal* , Oxidative Stress/drug effects , Brain/drug effects , Brain/metabolism , Brain/pathology, Animals ; Male ; Mice ; Diet, High-Fat ; Mitochondria/drug effects ; Mitochondria/metabolism ; Brain Injuries/drug therapy ; Brain Injuries/pathology ; Brain Injuries/metabolism ; Body Weight/drug effects
مستخلص:	Obesity causes inflammation in the adipose tissue and can affect the central nervous system, leading to oxidative stress and mitochondrial dysfunction. Therefore, it becomes necessary to seek new therapeutic alternatives. Gold nanoparticles (GNPs) could take carnitine to the adipose tissue, thus increasing fatty acid oxidation, reducing inflammation, and, consequently, restoring brain homeostasis. The objective of this study was to investigate the effects of GNPs associated with carnitine on the neurochemical parameters of obesity-induced mice. Eighty male Swiss mice that received a normal lipid diet (control group) or a high-fat diet (obese group) for 10 weeks were used. At the end of the sixth week, the groups were divided for daily treatment with saline, GNPs (70 µg/kg), carnitine (500 mg/kg), or GNPs associated with carnitine, respectively. Body weight was monitored weekly. At the end of the tenth week, the animals were euthanized and the mesenteric fat removed and weighed; the brain structures were separated for biochemical analysis. It was found that obesity caused oxidative damage and mitochondrial dysfunction in brain structures. Treatment with GNPs isolated reduced oxidative stress in the hippocampus. Carnitine isolated decreased the accumulation of mesenteric fat and oxidative stress in the hippocampus. The combination of treatments reduced the accumulation of mesenteric fat and mitochondrial dysfunction in the striatum. Therefore, these treatments in isolation, become a promising option for the treatment of obesity. (© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
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فهرسة مساهمة:	Keywords: Brain; Carnitine; Energy metabolism; Gold nanoparticles; Obesity; Oxidative stress
المشرفين على المادة:	S7UI8SM58A (Carnitine) 7440-57-5 (Gold)
تواريخ الأحداث:	Date Created: 20240131 Date Completed: 20240821 Latest Revision: 20240821
رمز التحديث:	20240822
DOI:	10.1007/s12035-024-03984-1
PMID:	38296901
قاعدة البيانات:	MEDLINE

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تدمد:	1559-1182
DOI:	10.1007/s12035-024-03984-1