دورية أكاديمية
أعرض في EDS

Human myofiber-enriched aging-induced lncRNA FRAIL1 promotes loss of skeletal muscle function.

التفاصيل البيبلوغرافية
العنوان: Human myofiber-enriched aging-induced lncRNA FRAIL1 promotes loss of skeletal muscle function.
المؤلفون: Miller MJ; Division of Endocrinology, Mayo Clinic, Rochester, Minnesota, USA.; University of Iowa, Iowa City, Iowa, USA., Gries KJ; Concordia University of Wisconsin, Milwaukee, Wisconsin, USA., Marcotte GR; Division of Endocrinology, Mayo Clinic, Rochester, Minnesota, USA.; University of Iowa, Iowa City, Iowa, USA., Ryan Z; Division of Endocrinology, Mayo Clinic, Rochester, Minnesota, USA., Strub MD; Division of Endocrinology, Mayo Clinic, Rochester, Minnesota, USA., Kunz HE; Division of Endocrinology, Mayo Clinic, Rochester, Minnesota, USA., Arendt BK; Division of Endocrinology, Mayo Clinic, Rochester, Minnesota, USA., Dasari S; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota, USA., Ebert SM; Division of Endocrinology, Mayo Clinic, Rochester, Minnesota, USA.; Emmyon, Inc., Rochester, Minnesota, USA., Adams CM; Division of Endocrinology, Mayo Clinic, Rochester, Minnesota, USA.; Emmyon, Inc., Rochester, Minnesota, USA., Lanza IR; Division of Endocrinology, Mayo Clinic, Rochester, Minnesota, USA.
المصدر: Aging cell [Aging Cell] 2024 Apr; Vol. 23 (4), pp. e14097. Date of Electronic Publication: 2024 Jan 31.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101130839 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1474-9726 (Electronic) Linking ISSN: 14749718 NLM ISO Abbreviation: Aging Cell Subsets: MEDLINE
أسماء مطبوعة: Publication: Oxford, UK : Wiley-Blackwell
Original Publication: Oxford, UK : Blackwell Pub., c2002-
مواضيع طبية MeSH: RNA, Long Noncoding*/genetics , RNA, Long Noncoding*/metabolism, Humans ; Animals ; Mice ; Aged ; Proteomics ; Muscle, Skeletal/metabolism ; Muscle Fibers, Skeletal/metabolism ; Aging/metabolism
مستخلص: The loss of skeletal muscle mass during aging is a significant health concern linked to adverse outcomes in older individuals. Understanding the molecular basis of age-related muscle loss is crucial for developing strategies to combat this debilitating condition. Long noncoding RNAs (lncRNAs) are a largely uncharacterized class of biomolecules that have been implicated in cellular homeostasis and dysfunction across a many tissues and cell types. To identify lncRNAs that might contribute to skeletal muscle aging, we screened for lncRNAs whose expression was altered in vastus lateralis muscle from older compared to young adults. We identified FRAIL1 as an aging-induced lncRNA with high abundance in human skeletal muscle. In healthy young and older adults, skeletal muscle FRAIL1 was increased with age in conjunction with lower muscle function. Forced expression of FRAIL1 in mouse tibialis anterior muscle elicits a dose-dependent reduction in skeletal muscle fiber size that is independent of changes in muscle fiber type. Furthermore, this reduction in muscle size is dependent on an intact region of FRAIL1 that is highly conserved across non-human primates. Unbiased transcriptional and proteomic profiling of the effects of FRAIL1 expression in mouse skeletal muscle revealed widespread changes in mRNA and protein abundance that recapitulate age-related changes in pathways and processes that are known to be altered in aging skeletal muscle. Taken together, these findings shed light on the intricate molecular mechanisms underlying skeletal muscle aging and implicate FRAIL1 in age-related skeletal muscle phenotypes.
(© 2024 The Authors. Aging Cell published by Anatomical Society and John Wiley & Sons Ltd.)
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معلومات مُعتمدة: NIA R44 AG047684 United States AG NIA NIH HHS; NIAMS R44 AR069400 United States AR NIAMS NIH HHS; NIAMS R01 AR071762 United States AR NIAMS NIH HHS; NIA R01 AG054454 United States AG NIA NIH HHS; R01 AG054454 United States AG NIA NIH HHS; NIA R01 AG060637 United States AG NIA NIH HHS; R44 AG047684 United States AG NIA NIH HHS; R44 AR069400 United States AR NIAMS NIH HHS
فهرسة مساهمة: Keywords: aging; lncRNA; skeletal muscle
المشرفين على المادة: 0 (RNA, Long Noncoding)
تواريخ الأحداث: Date Created: 20240201 Date Completed: 20240417 Latest Revision: 20240708
رمز التحديث: 20240709
مُعرف محوري في PubMed: PMC11019130
DOI: 10.1111/acel.14097
PMID: 38297807
قاعدة البيانات: MEDLINE
الوصف
تدمد:1474-9726
DOI:10.1111/acel.14097