دورية أكاديمية
The cckOMA syndrome and its relation to the Zollinger-Ellison syndrome: a diagnostic challenge.
| العنوان: | The cckOMA syndrome and its relation to the Zollinger-Ellison syndrome: a diagnostic challenge. |
|---|---|
| المؤلفون: | Rehfeld JF; Department of Clinical Biochemistry, University of Copenhagen, Rigshospitalet, Copenhagen, Denmark. |
| المصدر: | Scandinavian journal of gastroenterology [Scand J Gastroenterol] 2024 May; Vol. 59 (5), pp. 533-542. Date of Electronic Publication: 2024 Feb 01. |
| نوع المنشور: | Journal Article; Review; Case Reports |
| اللغة: | English |
| بيانات الدورية: | Publisher: Informa Healthcare Country of Publication: England NLM ID: 0060105 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1502-7708 (Electronic) Linking ISSN: 00365521 NLM ISO Abbreviation: Scand J Gastroenterol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : Informa Healthcare Original Publication: Oslo : Universitetsforlager |
| مواضيع طبية MeSH: | Cholecystokinin*/blood , Gastrins*/blood , Pancreatic Neoplasms*/diagnosis , Zollinger-Ellison Syndrome*/diagnosis, Female ; Humans ; Middle Aged ; Diagnosis, Differential ; Neuroendocrine Tumors/diagnosis ; Syndrome |
| مستخلص: | Objective: Among patients with enteropancreatic neuroendocrine tumor syndromes only one case with a cholecystokinin (CCK) secreting tumor has been reported. She had significant hyperCCKemia leading to a specific syndrome of severe diarrheas, weight loss, repeated duodenal ulcers and a permanently contracted gallbladder with gallstones. There are, however, reasons to believe that further CCKomas exist, for instance among Zollinger-Ellison patients with normal plasma gastrin concentrations. The present review is a call to gastroenterologists for awareness of such CCKoma patients. Method: After a short case report, the normal endocrine and oncological biology of CCK is described. Subsequently, the CCKoma symptoms are discussed with particular reference to the partly overlapping symptoms of the Zollinger-Ellison syndrome. In this context, the diagnostic use of truly specific CCK and gastrin assays are emphasized. The discussion also entails the problem of access to accurate CCK measurements. Conclusion: Obviously, the clinical awareness about the CCKoma syndrome is limited. Moreover, it is also likely that the knowledge about the necessary specificity demands of diagnostic gastrin and CCK assays have obscured proper diagnosis of the CCKoma syndromes in man. |
| فهرسة مساهمة: | Keywords: CCKoma; CCKoma syndrome; Cholecystokinin (CCK;); Zollinger–Ellison syndrome; diagnostic assays; gastrin; gastrinoma; islet-cell tumor; neuroendocrine tumors |
| المشرفين على المادة: | 9011-97-6 (Cholecystokinin) 0 (Gastrins) |
| تواريخ الأحداث: | Date Created: 20240201 Date Completed: 20240425 Latest Revision: 20240524 |
| رمز التحديث: | 20240525 |
| DOI: | 10.1080/00365521.2024.2308532 |
| PMID: | 38299632 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 1502-7708 |
|---|---|
| DOI: | 10.1080/00365521.2024.2308532 |