دورية أكاديمية
Toolkit for mapping the clonal landscape of tumor-infiltrating B cells.
| العنوان: | Toolkit for mapping the clonal landscape of tumor-infiltrating B cells. |
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| المؤلفون: | Serebrovskaya EO; Institute of Translational Medicine, Pirogov Russian National Research Medical University, Moscow, Russia; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, Moscow, Russia; Current position: Miltenyi Biotec B.V. & Co. KG, Bergisch Gladbach, Germany., Bryushkova EA; Institute of Translational Medicine, Pirogov Russian National Research Medical University, Moscow, Russia; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, Moscow, Russia; Department of Molecular Biology, Lomonosov Moscow State University, Moscow, Russia., Lukyanov DK; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, Moscow, Russia; Center of Life Sciences, Skolkovo Institute of Science and Technology, Moscow, Russia., Mushenkova NV; Institute of Translational Medicine, Pirogov Russian National Research Medical University, Moscow, Russia; Unicorn Capital Partners, 119049, Moscow, Russia., Chudakov DM; Institute of Translational Medicine, Pirogov Russian National Research Medical University, Moscow, Russia; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, Moscow, Russia; Center of Life Sciences, Skolkovo Institute of Science and Technology, Moscow, Russia; Central European Institute of Technology, Masaryk University, Brno, Czech Republic. Electronic address: chudakovdm@gmail.com., Turchaninova MA; Institute of Translational Medicine, Pirogov Russian National Research Medical University, Moscow, Russia; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, Moscow, Russia. |
| المصدر: | Seminars in immunology [Semin Immunol] 2024 Mar; Vol. 72, pp. 101864. Date of Electronic Publication: 2024 Jan 31. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Academic Press Country of Publication: England NLM ID: 9009458 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-3618 (Electronic) Linking ISSN: 10445323 NLM ISO Abbreviation: Semin Immunol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : Academic Press Original Publication: Philadelphia, PA : W.B. Saunders, c1989- |
| مواضيع طبية MeSH: | B-Lymphocyte Subsets* , Neoplasms*, Humans ; B-Lymphocytes ; Receptors, Antigen, B-Cell ; Tumor Microenvironment |
| مستخلص: | Our current understanding of whether B cell involvement in the tumor microenvironment benefits the patient or the tumor - in distinct cancers, subcohorts and individual patients - is quite limited. Both statements are probably true in most cases: certain clonal B cell populations contribute to the antitumor response, while others steer the immune response away from the desired mechanics. To step up to a new level of understanding and managing B cell behaviors in the tumor microenvironment, we need to rationally discern these roles, which are cumulatively defined by B cell clonal functional programs, specificities of their B cell receptors, specificities and isotypes of the antibodies they produce, and their spatial interactions within the tumor environment. Comprehensive analysis of these characteristics of clonal B cell populations is now becoming feasible with the development of a whole arsenal of advanced technical approaches, which include (1) methods of single-cell and spatial transcriptomics, genomics, and proteomics; (2) methods of massive identification of B cell specificities; (3) methods of deep error-free profiling of B cell receptor repertoires. Here we overview existing techniques, summarize their current application for B cells studies and propose promising future directions in advancing B cells exploration. (Copyright © 2024. Published by Elsevier Ltd.) |
| فهرسة مساهمة: | Keywords: BCR repertoire profiling and lineage; Mapping antigen-specific B cells; Research; Single-cell genomics, transcriptomics and proteomics in tumor-infiltrating B cell; Tracking |
| المشرفين على المادة: | 0 (Receptors, Antigen, B-Cell) |
| تواريخ الأحداث: | Date Created: 20240201 Date Completed: 20240401 Latest Revision: 20240401 |
| رمز التحديث: | 20240401 |
| DOI: | 10.1016/j.smim.2024.101864 |
| PMID: | 38301345 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1096-3618 |
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| DOI: | 10.1016/j.smim.2024.101864 |