دورية أكاديمية
Pattern of recurrence in endometrial cancer. The murderer always returns to the scene of the crime.
| العنوان: | Pattern of recurrence in endometrial cancer. The murderer always returns to the scene of the crime. |
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| المؤلفون: | Capozzi VA; Department of Medicine and Surgery, University Hospital of Parma, Parma, 43125, Italy., Monfardini L; Department of Medicine and Surgery, University Hospital of Parma, Parma, 43125, Italy., Maglietta G; Clinical and Epidemiological Research Unit, University Hospital of Parma, 43125, Parma, Italy. Electronic address: gmaglietta@ao.pr.it., Barresi G; Department of Medicine and Surgery, University Hospital of Parma, Parma, 43125, Italy., De Finis A; Department of Medicine and Surgery, University Hospital of Parma, Parma, 43125, Italy., Rosati A; Department of Woman, Child and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy., Vargiu V; Department of Woman, Child and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy., Cosentino F; Department of Medicine and Health Sciences, University of Molise Studies, Campobasso, Italy; Department of Oncology, Gemelli Molise Spa, Campobasso, Italy., Sozzi G; Department of Gynecologic Oncology, University of Palermo, 90127, Palermo, Italy., Chiantera V; Department of Gynecologic Oncology, University of Palermo, 90127, Palermo, Italy., Bogani G; Department of Gynecologic Oncology, IRCCS National Cancer Institute, Milan, Italy., Carnelli M; Division of Gynecology and Obstetrics, ASST Papa Giovanni XXIII, Bergamo, Italy., Scambia G; Department of Woman, Child and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy., Fanfani F; Department of Woman, Child and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy., Ghi T; Department of Medicine and Surgery, University Hospital of Parma, Parma, 43125, Italy., Berretta R; Department of Medicine and Surgery, University Hospital of Parma, Parma, 43125, Italy. |
| المصدر: | European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology [Eur J Surg Oncol] 2024 Mar; Vol. 50 (3), pp. 107985. Date of Electronic Publication: 2024 Jan 28. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: England NLM ID: 8504356 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-2157 (Electronic) Linking ISSN: 07487983 NLM ISO Abbreviation: Eur J Surg Oncol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Original Publication: London ; New York : Academic Press, [1985- |
| مواضيع طبية MeSH: | Neoplasm Recurrence, Local*/pathology , Endometrial Neoplasms*/surgery , Endometrial Neoplasms*/pathology, Female ; Humans ; Retrospective Studies ; Neoplasm Staging ; Crime ; Recurrence ; Lymph Node Excision |
| مستخلص: | Background: Endometrial cancer recurrence occurs in about 18 % of patients. This study aims to analyze the pattern recurrence of endometrial cancer and the relationship between the initial site of primary disease and the relapse site in patients undergoing surgical treatment. Methods: We retrospectively reviewed all surgically treated patients with endometrial cancer selecting those with recurrence. We defined primary site disease as uterus, lymph nodes, or peritoneum according to pathology analysis of the surgical specimen. The site of recurrence was defined as vaginal cuff, lymph nodes, peritoneum, and parenchymatous organs. Our primary endpoint was to correlate the site of initial disease with the site of recurrence. Results: The study enrolled 1416 patients. The overall recurrence rate was 17,5 % with 248 relapses included in the study. An increase of 9.9, 5.7, and 5.7 times in the odds of relapse on the lymph node, peritoneum, and abdominal parenchymatous sites respectively was observed in case of nodal initial disease (p < 0.001). A not significant difference in odds was observed in terms of vaginal cuff relapse (OR 0.9) between lymph node ad uterine primary disease (p = 0.78). An increasing OR of 8.7 times for nodal recurrences, 46.6 times for peritoneum, and 23.3 times for parenchymatous abdominal recurrences were found in the case of primary peritoneal disease (p < 0.001). Conclusion: Endometrial cancer tends to recur at the initial site of the disease. Intraoperative inspection of the adjacent sites of primary disease and targeted instrumental examination of the initial sites of disease during follow-up are strongly recommended. Competing Interests: Declaration of competing interest The authors declare that they have no conflict of interest. (© 2024 Elsevier Ltd, BASO ∼ The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Edometrial cancer; Lymph node; Metastasis; Peritoneum; Recurrence; Vaginal cuff |
| تواريخ الأحداث: | Date Created: 20240201 Date Completed: 20240311 Latest Revision: 20240311 |
| رمز التحديث: | 20240311 |
| DOI: | 10.1016/j.ejso.2024.107985 |
| PMID: | 38301532 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1532-2157 |
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| DOI: | 10.1016/j.ejso.2024.107985 |