دورية أكاديمية
Chemical characterization of three different extracts obtained from Chelidonium majus L. (Greater celandine) with insights into their in vitro, in silico and network pharmacological properties.
| العنوان: | Chemical characterization of three different extracts obtained from Chelidonium majus L. (Greater celandine) with insights into their in vitro, in silico and network pharmacological properties. |
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| المؤلفون: | Terzic M; University of Novi Sad, Faculty of Technology, Bulevar cara Lazara 1, 21000 Novi Sad, Serbia., Fayez S; Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, Cairo 11566, Egypt., Fahmy NM; Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, Cairo 11566, Egypt., Eldahshan OA; Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, Cairo 11566, Egypt., Uba AI; Department of Molecular Biology and Genetics, Istanbul AREL University, Istanbul 34537, Turkey., Ponniya SKM; Department of Bioinformatics, Pondicherry University, Pudhucherry, India., Selvi S; Department of Plant and Animal Production, Altınoluk Vocational School, Balıkesir University, Balıkesir, Turkey., Nilofar; Physiology and Biochemistry Laboratory, Department of Biology, Science Faculty, Selcuk University, Konya 42130, Turkey; Department of Pharmacy, Botanic Garden 'Giardino dei Semplici', Università degli Studi 'Gabriele d'Annunzio', via dei Vestini 31, 66100 Chieti, Italy., Koyuncu I; Department of Medical Biochemistry, Faculty of Medicine, Harran University, Sanliurfa 63290, Turkey., Yüksekdağ Ö; Department of Medical Biochemistry, Faculty of Medicine, Harran University, Sanliurfa 63290, Turkey., Zengin G; Physiology and Biochemistry Laboratory, Department of Biology, Science Faculty, Selcuk University, Konya 42130, Turkey. Electronic address: gokhanzengin@selcuk.edu.tr. |
| المصدر: | Fitoterapia [Fitoterapia] 2024 Apr; Vol. 174, pp. 105835. Date of Electronic Publication: 2024 Jan 30. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 16930290R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6971 (Electronic) Linking ISSN: 0367326X NLM ISO Abbreviation: Fitoterapia Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 1999- : [Amsterdam] : Elsevier Original Publication: Milano : Inverni & Della Beffa S.p.A. |
| مواضيع طبية MeSH: | Alkaloids*/pharmacology , Alkaloids*/chemistry , Chelidonium*/chemistry , Acetates*, Humans ; Plant Extracts/chemistry ; Chelidonium majus ; Methanol ; HEK293 Cells ; Molecular Structure ; Solvents/chemistry ; Antioxidants ; Water |
| مستخلص: | Plant species C. majus, which is a very rich source of secondary metabolites, was used to obtain extracts, using a conventional extraction technique. For the extraction of bioactive molecules, three solvents were used: ethyl acetate, methanol and water, which differ from each other based on their polarity. The obtained extracts were examined in terms of chemical composition, antioxidant, enzyme inhibitory activity, and cytotoxic effects. The research results indicate that methanol was a better and more efficient extractant in the process of isolating bioactive compounds than ethyl acetate and water. The chemical composition of this solvent, i.e. its polarity, contributed the most to the extraction of alkaloids and flavonoids. The high content of total phenolic compounds in the methanol extract, as well as individual alkaloids, caused a very strong antioxidant activity, as well as a strong inhibitory power when it comes to inhibiting the excessive activity of cholinesterase and tyrosinase. Methanol and ethyl acetate extracts achieved very good cytotoxic activity against cancerous cells HGC-27 and HT-29 and did not exert a toxic effect on non-cancerous cell lines (HEK293). Extracts of plant species C. majus, especially methanol extract could be characterized as a very good starting plant material for the formulation of products intended for various branches of the food and pharmaceutical industry. Competing Interests: Declaration of competing interest The authors declare no competing interests. (Copyright © 2024 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Biological potential; C. majus; Chemical composition; Solvent extraction |
| المشرفين على المادة: | 0 (Plant Extracts) 76845O8NMZ (ethyl acetate) Y4S76JWI15 (Methanol) 0 (Alkaloids) 0 (Solvents) 0 (Antioxidants) 059QF0KO0R (Water) 0 (Acetates) |
| تواريخ الأحداث: | Date Created: 20240201 Date Completed: 20240325 Latest Revision: 20240325 |
| رمز التحديث: | 20240325 |
| DOI: | 10.1016/j.fitote.2024.105835 |
| PMID: | 38301936 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1873-6971 |
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| DOI: | 10.1016/j.fitote.2024.105835 |