دورية أكاديمية
[A Case of Recurrent Breast Cancer That Was BRCA1 Pathogenic Variant-Positive Successfully Treated with PARP Inhibitor].
| العنوان: | [A Case of Recurrent Breast Cancer That Was BRCA1 Pathogenic Variant-Positive Successfully Treated with PARP Inhibitor]. |
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| المؤلفون: | Aoyagi T; Dept. of Breast Surgery, Funabashi Municipal Medical Center., Namura M, Sakata H, Tamanuki T, Iwai M, Iwata K, Takahashi H, Matsuzaki H |
| المصدر: | Gan to kagaku ryoho. Cancer & chemotherapy [Gan To Kagaku Ryoho] 2023 Dec; Vol. 50 (13), pp. 1462-1464. |
| نوع المنشور: | Case Reports; English Abstract; Journal Article |
| اللغة: | Japanese |
| بيانات الدورية: | Publisher: Gan To Kagaku Ryohosha Country of Publication: Japan NLM ID: 7810034 Publication Model: Print Cited Medium: Print ISSN: 0385-0684 (Print) Linking ISSN: 03850684 NLM ISO Abbreviation: Gan To Kagaku Ryoho Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Tokyo : Gan To Kagaku Ryohosha Original Publication: Tōkyō, Gan to Kagaku Ryōhōsha [1974?]- |
| مواضيع طبية MeSH: | Breast Neoplasms*/drug therapy , Breast Neoplasms*/genetics , Breast Neoplasms*/surgery , Antineoplastic Agents*/therapeutic use, Female ; Humans ; Aged ; Middle Aged ; Poly(ADP-ribose) Polymerase Inhibitors/therapeutic use ; Mastectomy ; Neoplasm Recurrence, Local/drug therapy ; Neoplasm Recurrence, Local/surgery ; BRCA1 Protein/genetics |
| مستخلص: | The patient was a 51-year-old woman at the time of diagnosis of left breast cancer. She underwent a mastectomy and axillary dissection. Pathological findings were invasive ductal carcinoma of the breast, tumor diameter 25 mm, and metastasis in 2 of 16 removed axillary lymph nodes. The subtype was triple negative. Postoperative chemotherapy was administered, and the patient was followed by follow-up imaging. At the age of 63 years, ultrasonography showed local recurrence, and local mass excision was performed. Genetic abnormalities were suspected since she had a family history of breast cancer, and it was a recurrent case. After genetic counseling, she underwent genetic testing, which revealed a BRCA1 pathogenic variant, so we initiated imaging surveillance. At age 65, a chest CT scan was performed due to respiratory symptoms, and she was diagnosed with multiple lung metastases. Respiratory symptoms improved at the examination 1 month after administration of Poly ADP ribose polymerase(PARP)inhibitor, and the metastatic masses shrank at the CT scan 3 months later. She continues to maintain CR and has no respiratory symptoms at present. |
| المشرفين على المادة: | 0 (Poly(ADP-ribose) Polymerase Inhibitors) 0 (Antineoplastic Agents) 0 (BRCA1 protein, human) 0 (BRCA1 Protein) |
| تواريخ الأحداث: | Date Created: 20240202 Date Completed: 20240205 Latest Revision: 20240206 |
| رمز التحديث: | 20240206 |
| PMID: | 38303308 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0385-0684 |
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