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Acylation stimulating protein/C3adesArg in the metabolic states: role of adipocyte dysfunction in obesity complications.

التفاصيل البيبلوغرافية
العنوان: Acylation stimulating protein/C3adesArg in the metabolic states: role of adipocyte dysfunction in obesity complications.
المؤلفون: Rezvani R; Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran., Shadmand Foumani Moghadam MR; Department of Nutrition, Emam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran., Cianflone K; Centre de Recherche Institut Universitaire de Cardiologie & Pneumologie de Québec, Université Laval, Québec, Québec, Canada.
المصدر: The Journal of physiology [J Physiol] 2024 Mar; Vol. 602 (5), pp. 773-790. Date of Electronic Publication: 2024 Feb 02.
نوع المنشور: Review; Journal Article
اللغة: English
بيانات الدورية: Publisher: Cambridge Univ. Press Country of Publication: England NLM ID: 0266262 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-7793 (Electronic) Linking ISSN: 00223751 NLM ISO Abbreviation: J Physiol Subsets: MEDLINE
أسماء مطبوعة: Publication: Oxford : Blackwell : Cambridge Univ. Press
Original Publication: London, Cambridge Univ. Press.
مواضيع طبية MeSH: Adipocytes*/metabolism , Adipose Tissue*/metabolism , Complement C3a*, Female ; Humans ; Male ; Obesity/metabolism ; Adipokines/metabolism
مستخلص: Adipose tissue, as an endocrine organ, secretes several adipocyte-derived hormones named 'adipokines' that are implicated in regulating energy haemostasis. Substantial evidence shows that white adipose tissue-derived adipokines mediate the link between obesity-related exogenous factors (like diet and lifestyle) and various biological events (such as pre- and postmenopausal status) that have obesity consequences (cardiometabolic disorders). One of the critical aetiological factors for obesity-related diseases is the dysfunction of adipokine pathways. Acylation-stimulating protein (ASP) is an adipokine that stimulates triglyceride synthesis and storage in adipose tissue by enhancing glucose and fatty acid uptake. ASP acts via its receptor C5L2. The primary objective of this review is to address the existing gap in the literature regarding ASP by investigating its diverse responses and receptor interactions across multiple determinants of obesity. These determinants include diet composition, metabolic disorders, organ involvement, sex and sex hormone levels. Furthermore, this article explores the broader paradigm shift from solely focusing on adipose tissue mass, which contributes to obesity, to considering the broader implications of adipose tissue function. Additionally, we raise a critical question concerning the clinical relevance of the insights gained from this review, both in terms of potential therapeutic interventions targeting ASP and in the context of preventing obesity-related conditions, highlighting the potential of the ASP-C5L2 interaction as a pharmacological target. In conclusion, these findings validate that obesity is a low-grade inflammatory status with multiorgan involvement and sex differences, demonstrating dynamic interactions between immune and metabolic response determinants.
(© 2024 The Authors. The Journal of Physiology © 2024 The Physiological Society.)
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فهرسة مساهمة: Keywords: ASP; adipokines; complement C3; metabolic syndrome
المشرفين على المادة: 0 (complement C3a, des-Arg-(77)-)
0 (Adipokines)
80295-42-7 (Complement C3a)
تواريخ الأحداث: Date Created: 20240202 Date Completed: 20240311 Latest Revision: 20240311
رمز التحديث: 20240311
DOI: 10.1113/JP285127
PMID: 38305477
قاعدة البيانات: MEDLINE
الوصف
تدمد:1469-7793
DOI:10.1113/JP285127