دورية أكاديمية
Distinguishing community-acquired bacterial and viral meningitis: Microbes and biomarkers.
| العنوان: | Distinguishing community-acquired bacterial and viral meningitis: Microbes and biomarkers. |
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| المؤلفون: | Ivaska L; Department of Paediatrics and Adolescent Medicine, Turku University Hospital and University of Turku, Savitehtaankatu 5, 20521 Turku, Finland; InFLAMES Research Flagship Center, University of Turku, Kiinanmyllynkatu 10, 20520 Turku, Finland. Electronic address: lauri.ivaska@utu.fi., Herberg J; Section of Paediatric Infectious Disease, Faculty of Medicine, Imperial College London, Norfolk Place, London, United Kingdom. Electronic address: j.herberg@imperial.ac.uk., Sadarangani M; Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada; Vaccine Evaluation Center, BC Children's Hospital Research Institute, Vancouver, British Columbia, Canada. Electronic address: msadarangani@bcchr.ubc.ca. |
| المصدر: | The Journal of infection [J Infect] 2024 Mar; Vol. 88 (3), pp. 106111. Date of Electronic Publication: 2024 Feb 01. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: W.B. Saunders Country of Publication: England NLM ID: 7908424 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-2742 (Electronic) Linking ISSN: 01634453 NLM ISO Abbreviation: J Infect Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Kent, UK : W.B. Saunders Original Publication: London, New York, Academic Press. |
| مواضيع طبية MeSH: | Meningitis, Viral*/diagnosis , Meningitis, Bacterial*/diagnosis, Humans ; Proteomics ; Diagnosis, Differential ; Biomarkers ; Anti-Bacterial Agents/therapeutic use |
| مستخلص: | Diagnostic tools to differentiate between community-acquired bacterial and viral meningitis are essential to target the potentially lifesaving antibiotic treatment to those at greatest risk and concurrently spare patients with viral meningitis from the disadvantages of antibiotics. In addition, excluding bacterial meningitis and thus decreasing antibiotic consumption would be important to help reduce antimicrobial resistance and healthcare expenses. The available diagnostic laboratory tests for differentiating bacterial and viral meningitis can be divided microbiological pathogen-focussed methods and biomarkers of the host response. Bacterial culture-independent microbiological methods, such as highly multiplexed nucleic acid amplification tests, are rapidly making their way into the clinical practice. At the same time, more conventional host protein biomarkers, such as procalcitonin and C-reactive protein, are supplemented by newer proteomic and transcriptomic signatures. This review aims to summarise the current state and the recent advances in diagnostic methods to differentiate bacterial from viral meningitis. Competing Interests: Declaration of Competing Interest MS has been an investigator on projects funded by GlaxoSmithKline, Merck, Moderna, Pfizer, Sanofi-Pasteur, Seqirus, Symvivo and VBI Vaccines. All funds have been paid to his institute, and he has not received any personal payments. JH holds patents on gene expression signatures for host response-based diagnostic tests, although no tests are commercially available. Other authors have no competing interests to declare. (Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Aseptic; Bacterial; Biomarker; Meningitis; Meningitis panel; Viral |
| المشرفين على المادة: | 0 (Biomarkers) 0 (Anti-Bacterial Agents) |
| تواريخ الأحداث: | Date Created: 20240202 Date Completed: 20240319 Latest Revision: 20240319 |
| رمز التحديث: | 20240319 |
| DOI: | 10.1016/j.jinf.2024.01.010 |
| PMID: | 38307149 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1532-2742 |
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| DOI: | 10.1016/j.jinf.2024.01.010 |