دورية أكاديمية
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Effectiveness of dexmedetomidine during surgery under general anaesthesia on patient-centred outcomes: a systematic review and Bayesian meta-analysis protocol.

التفاصيل البيبلوغرافية
العنوان: Effectiveness of dexmedetomidine during surgery under general anaesthesia on patient-centred outcomes: a systematic review and Bayesian meta-analysis protocol.
المؤلفون: Verret M; Departments of Anesthesiology and Critical Care Medicine, Faculty of Medicine, Université Laval, Québec, Quebec, Canada Michael.verret.med@ssss.gouv.qc.ca.; Population Health and Optimal Health Practices Research Unit (Trauma - Emergency - Critical Care Medicine), CHU de Québec - Université Laval Research Center, Québec, Quebec, Canada.; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.; School of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario, Canada., Le JBP; Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada., Lalu MM; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.; School of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario, Canada.; Department of Anesthesiology and Pain Medicine, The Ottawa Hospital, Ottawa, Ontario, Canada., McIsaac DI; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.; School of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario, Canada.; Department of Anesthesiology and Pain Medicine, The Ottawa Hospital, Ottawa, Ontario, Canada., Nicholls S; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada., Turgeon AF; Departments of Anesthesiology and Critical Care Medicine, Faculty of Medicine, Université Laval, Québec, Quebec, Canada.; Population Health and Optimal Health Practices Research Unit (Trauma - Emergency - Critical Care Medicine), CHU de Québec - Université Laval Research Center, Québec, Quebec, Canada., Hutton B; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.; School of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario, Canada., Zivkovic F; Patient Partner, The Ottawa Hospital, Ottawa, Ontario, Canada., Graham M; Patient Partner, The Ottawa Hospital, Ottawa, Ontario, Canada., Le M; Patient Partner, The Ottawa Hospital, Ottawa, Ontario, Canada., Geist A; Patient Partner, The Ottawa Hospital, Ottawa, Ontario, Canada., Berube M; Population Health and Optimal Health Practices Research Unit (Trauma - Emergency - Critical Care Medicine), CHU de Québec - Université Laval Research Center, Québec, Quebec, Canada.; Faculty of Nursing, Université Laval, Québec, Quebec, Canada., Gilron I; Department of Anesthesiology and Perioperative Medicine, Queen's University, Kingston, Ontario, Canada., Poulin P; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.; School of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario, Canada., Daudt H; Pain Canada, Pain BC, Vancouver, Alberta, Canada., Martel G; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.; Department of Surgery, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada., McVicar J; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.; Department of Anesthesiology and Pain Medicine, The Ottawa Hospital, Ottawa, Ontario, Canada., Moloo H; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.; Department of Surgery, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada., Fergusson DA; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.; School of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario, Canada.; Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.; Department of Surgery, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
المصدر: BMJ open [BMJ Open] 2024 Feb 01; Vol. 14 (2), pp. e080012. Date of Electronic Publication: 2024 Feb 01.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: BMJ Publishing Group Ltd Country of Publication: England NLM ID: 101552874 Publication Model: Electronic Cited Medium: Internet ISSN: 2044-6055 (Electronic) Linking ISSN: 20446055 NLM ISO Abbreviation: BMJ Open
أسماء مطبوعة: Original Publication: [London] : BMJ Publishing Group Ltd, 2011-
مواضيع طبية MeSH: Dexmedetomidine*/therapeutic use , Systematic Reviews as Topic* , Meta-Analysis as Topic* , Anesthesia, General* , Bayes Theorem* , Pain, Postoperative*/drug therapy, Humans ; Analgesics, Non-Narcotic/therapeutic use ; Analgesics, Opioid/therapeutic use ; Patient-Centered Care ; Quality of Life ; Research Design
مستخلص: Introduction: Dexmedetomidine is a promising pharmaceutical strategy to minimise opioid use during surgery. Despite its growing use, it is uncertain whether dexmedetomidine can improve patient-centred outcomes such as quality of recovery and pain.
Methods and Analysis: We will conduct a systematic review and meta-analysis following the recommendations of the Cochrane Handbook for Systematic Reviews . We will search MEDLINE, Embase, CENTRAL, Web of Science and CINAHL approximately in October 2023. We will include randomised controlled trials evaluating the impact of systemic intraoperative dexmedetomidine on patient-centred outcomes. Patient-centred outcome definition will be based on the consensus definition established by the Standardised Endpoints in Perioperative Medicine initiative (StEP-COMPAC). Our primary outcome will be the quality of recovery after surgery. Our secondary outcomes will be patient well-being, function, health-related quality of life, life impact, multidimensional assessment of postoperative acute pain, chronic pain, persistent postoperative opioid use, opioid-related adverse events, hospital length of stay and adverse events. Two reviewers will independently screen and identify trials and extract data. We will evaluate the risk of bias of trials using the Cochrane Risk of Bias Tool (RoB 2.0). We will synthesise data using a random effects Bayesian model framework, estimating the probability of achieving a benefit and its clinical significance. We will assess statistical heterogeneity with the tau-squared and explore sources of heterogeneity with meta-regression. We have involved patient partners, clinicians, methodologists, and key partner organisations in the development of this protocol, and we plan to continue this collaboration throughout all phases of this systematic review.
Ethics and Dissemination: Our systematic review does not require research ethics approval. It will help inform current clinical practice guidelines and guide development of future randomised controlled trials. The results will be disseminated in open-access peer-reviewed journals, presented at conferences and shared among collaborators and networks.
Prospero Registration Number: CRD42023439896.
Competing Interests: Competing interests: IG has received consulting fees from GW Research, Eupraxia, Biogen and Novaremed.
(© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
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فهرسة مساهمة: Keywords: Adult anaesthesia; CLINICAL PHARMACOLOGY; Pain management; Patient Reported Outcome Measures; Patient-Centered Care; SURGERY
المشرفين على المادة: 67VB76HONO (Dexmedetomidine)
0 (Analgesics, Non-Narcotic)
0 (Analgesics, Opioid)
تواريخ الأحداث: Date Created: 20240202 Date Completed: 20240807 Latest Revision: 20240807
رمز التحديث: 20240808
مُعرف محوري في PubMed: PMC10836371
DOI: 10.1136/bmjopen-2023-080012
PMID: 38307526
قاعدة البيانات: MEDLINE
الوصف
تدمد:2044-6055
DOI:10.1136/bmjopen-2023-080012