دورية أكاديمية
أعرض في EDS

High-sensitivity C-reactive protein among people living with HIV on highly active antiretroviral therapy: a systemic review and meta-analysis.

التفاصيل البيبلوغرافية
العنوان: High-sensitivity C-reactive protein among people living with HIV on highly active antiretroviral therapy: a systemic review and meta-analysis.
المؤلفون: Mabhida SE; Non-Communicable Diseases Research Unit, South African Medical Research Council, Tygerberg, 7505, South Africa. smabhida@mrc.ac.za., Mchiza ZJ; Non-Communicable Diseases Research Unit, South African Medical Research Council, Tygerberg, 7505, South Africa.; School of Public Health, University of the Western Cape, Bellville, 7535, South Africa., Mokgalaboni K; Department of Life and Consumer Sciences, University of South Africa, Roodepoort, 1709, South Africa., Hanser S; Department of Physiology and Environmental Health, University of Limpopo, Sovenga, 0727, South Africa., Choshi J; Department of Physiology and Environmental Health, University of Limpopo, Sovenga, 0727, South Africa., Mokoena H; Department of Physiology and Environmental Health, University of Limpopo, Sovenga, 0727, South Africa., Ziqubu K; Department of Biochemistry, North-West University, Mmabatho, 2745, South Africa., Masilela C; Department of Biochemistry and Microbiology, University of Zululand, KwaDlangezwa, Richards Bay, 3880, South Africa., Nkambule BB; School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, 4000, South Africa., Ndwandwe DE; Cochrane South Africa, South African Medical Research Council, Tygerberg, 7505, South Africa., Kengne AP; Non-Communicable Diseases Research Unit, South African Medical Research Council, Tygerberg, 7505, South Africa.; Department of Medicine, University of Cape Town, Cape Town, 7700, South Africa., Dludla PV; Cochrane South Africa, South African Medical Research Council, Tygerberg, 7505, South Africa.; Department of Biochemistry and Microbiology, University of Zululand, KwaDlangezwa, Richards Bay, 3880, South Africa.
المصدر: BMC infectious diseases [BMC Infect Dis] 2024 Feb 02; Vol. 24 (1), pp. 160. Date of Electronic Publication: 2024 Feb 02.
نوع المنشور: Meta-Analysis; Systematic Review; Journal Article
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 100968551 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2334 (Electronic) Linking ISSN: 14712334 NLM ISO Abbreviation: BMC Infect Dis Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central, [2001-
مواضيع طبية MeSH: HIV Infections*/complications , HIV Infections*/drug therapy , HIV Infections*/epidemiology , Cardiovascular Diseases*/etiology , Cardiovascular Diseases*/complications, Humans ; Adult ; Antiretroviral Therapy, Highly Active ; C-Reactive Protein ; HIV ; Lipids
مستخلص: The pathological consequences of inflammation persist in people living with the human immunodeficiency virus (PLWH), regardless of the positive outcomes of highly active antiretroviral therapy (HAART). The current systematic review and meta-analysis aims to understand and explore the levels of high-sensitivity C-reactive protein (hs-CRP) and other cardiovascular disease (CVD)-risk factors including lipid profiles among PLWH on HAART. Major electronic databases including PubMed, Scopus, and Web of Science were searched to retrieve relevant global literature reporting on hs-CRP levels in PLWH on HAART. A total of twenty-two studies with an average participant age of 40 years were eligible for this systematic review and meta-analysis. Majority of the included studies were from Africa (n = 11), the United States (n = 6), and Europe (n = 5). Our systemic review showed that most studies reported increased levels of hs-CRP among PLWH on HAART when compared to controls (PLWH not on HAART or those without HIV), especially in studies from Africa. This was supported by a meta-analysis showing significantly elevated levels of hs-CRP in PLWH on HAART when compared to PLWH not on HAART (standardised mean difference [SMD] = 0.56; 95% CI = 0.10‑1.01, z = 2.41; p = 0.02) or those without HIV (SMD = 1.19; 95% CI = 0.76‑1.63, z = 5.35; p < 0.001). Where lipid profiles, as a major predictor for CVD risk, were also impaired in PLWH on HAART when compared to PLWH not on HAART and HIV-negative participants. In conclusion, elevated levels of hs-CRP and lipid levels are prevalent in PLWH on HAART, this may increase the risk of CVD complications, especially for those people living in Africa. However, more evidence in larger population studies is required to confirm these outcomes and unveil any possible clinical implications of HAART-induced modulation of hs-CRP levels in PLWH.
(© 2024. The Author(s).)
References: Circ Cardiovasc Imaging. 2016 Mar;9(3):e004427. (PMID: 26951604)
Cardiovasc Toxicol. 2004;4(3):303-16. (PMID: 15470277)
Clin Immunol. 2005 Nov;117(2):104-11. (PMID: 16214080)
Open Cardiovasc Med J. 2011;5:49-63. (PMID: 21643501)
AIDS. 2009 May 15;23(8):929-39. (PMID: 19425222)
HIV AIDS (Auckl). 2016 Oct 25;8:165-174. (PMID: 27822124)
J Infect Dis. 2010 Jun 15;201(12):1788-95. (PMID: 20446848)
Lancet. 2017 Jan 7;389(10064):37-55. (PMID: 27863813)
AIDS. 2013 Oct 23;27(16):2603-14. (PMID: 24100713)
J AIDS Clin Res. 2015 Mar;6(3):. (PMID: 26038711)
Platelets. 2020 Aug 17;31(6):756-762. (PMID: 31608753)
N Engl J Med. 2005 Apr 21;352(16):1721-2; author reply 1721-2. (PMID: 15843678)
PLoS One. 2017 Sep 20;12(9):e0185003. (PMID: 28931072)
Front Immunol. 2021 Jul 05;12:647805. (PMID: 34290695)
Cytokine. 2020 Feb;126:154892. (PMID: 31704479)
Hypertension. 2001 Apr;37(4):1053-9. (PMID: 11304502)
AIDS. 2003 May 23;17(8):1179-93. (PMID: 12819520)
J Cell Physiol. 2018 Nov;233(11):8508-8525. (PMID: 29932219)
AIDS. 2009 Jun 1;23(9):1059-67. (PMID: 19390417)
CMAJ. 2004 May 11;170(10):1563-5. (PMID: 15136550)
JAMA. 2022 Sep 13;328(10):931-932. (PMID: 36098735)
Lancet. 2014 Sep 13;384(9947):1005-70. (PMID: 25059949)
Lancet HIV. 2017 Aug;4(8):e349-e356. (PMID: 28501495)
HIV Med. 2012 Nov;13(10):609-16. (PMID: 22624591)
BMC Res Notes. 2015 Jun 06;8:224. (PMID: 26048813)
Circulation. 2003 Jan 28;107(3):363-9. (PMID: 12551853)
BMC Infect Dis. 2014 Sep 29;14:521. (PMID: 25266928)
BMC Infect Dis. 2013 Sep 03;13:414. (PMID: 24004495)
Eur Heart J. 2010 Dec;31(23):2844-53. (PMID: 20965889)
BMJ Open. 2022 Jun 6;12(6):e062352. (PMID: 35667720)
Afr J Reprod Health. 2014 Sep;18(3 Spec No):84-92. (PMID: 26050380)
Lancet. 2000 Apr 1;355(9210):1158-9. (PMID: 10791383)
PLoS One. 2015 Dec 04;10(12):e0144317. (PMID: 26636578)
Ann Transl Med. 2019 Sep;7(18):436. (PMID: 31700872)
Heart Lung Circ. 2014 Feb;23(2):119-26. (PMID: 23978476)
BMC Med Res Methodol. 2005 Apr 20;5:13. (PMID: 15840177)
J Oral Pathol Med. 2010 May;39(5):397-406. (PMID: 20202089)
Open Biochem J. 2017 Dec 28;11:105-118. (PMID: 29387269)
AIDS. 2015 Aug 24;29(13):1617-22. (PMID: 26372272)
Front Immunol. 2018 Apr 13;9:754. (PMID: 29706967)
Glob Heart. 2020 Nov 03;15(1):74. (PMID: 33299770)
J Immunol Res. 2021 Sep 29;2021:7316456. (PMID: 34631899)
J Epidemiol. 2007 Jul;17(4):120-4. (PMID: 17641447)
PLoS One. 2020 Aug 20;15(8):e0237739. (PMID: 32817629)
Scand J Clin Lab Invest. 1996 Apr;56(2):123-7. (PMID: 8743104)
Front Cardiovasc Med. 2021 Nov 25;8:745539. (PMID: 34901209)
Exp Ther Med. 2020 Aug;20(2):1211-1219. (PMID: 32765664)
PLoS One. 2012;7(9):e44454. (PMID: 22970224)
PLoS One. 2013 Oct 15;8(10):e77379. (PMID: 24143226)
Atherosclerosis. 2015 May;240(1):154-60. (PMID: 25795556)
AIDS Res Hum Retroviruses. 2013 Mar;29(3):493-500. (PMID: 23062187)
Ann Intern Med. 2009 Oct 6;151(7):483-95. (PMID: 19805771)
Lancet Glob Health. 2019 Nov;7(11):e1521-e1540. (PMID: 31607465)
J Int AIDS Soc. 2023 Mar;26(3):e26059. (PMID: 36924213)
J Acquir Immune Defic Syndr. 2009 Dec 1;52(4):480-7. (PMID: 19911471)
AIDS Rev. 2020 Oct 26;23(1):1-12. (PMID: 33105472)
PLoS One. 2015 Apr 27;10(4):e0117125. (PMID: 25915208)
Med Sci Monit. 2021 Aug 23;27:e934475. (PMID: 34421116)
Glob Heart. 2020 Feb 12;15(1):15. (PMID: 32489788)
Curr HIV Res. 2017;15(6):411-421. (PMID: 29165087)
BMC Infect Dis. 2011 Feb 04;11:40. (PMID: 21294867)
PLoS One. 2014 Feb 28;9(2):e89537. (PMID: 24586854)
Am J Epidemiol. 1996 Sep 15;144(6):537-47. (PMID: 8797513)
BMC Immunol. 2015 Jul 24;16:43. (PMID: 26204934)
فهرسة مساهمة: Keywords: Cardiovascular disease risk; High-sensitivity C-reactive protein; Highly active antiretroviral therapy; Human immunodeficiency virus; Inflammation
المشرفين على المادة: 9007-41-4 (C-Reactive Protein)
0 (Lipids)
تواريخ الأحداث: Date Created: 20240202 Date Completed: 20240205 Latest Revision: 20240213
رمز التحديث: 20240213
مُعرف محوري في PubMed: PMC10838000
DOI: 10.1186/s12879-024-09050-4
PMID: 38308222
قاعدة البيانات: MEDLINE
الوصف
تدمد:1471-2334
DOI:10.1186/s12879-024-09050-4