دورية أكاديمية
From waste to bioactive compounds: A response surface methodology approach to extract antioxidants from Pistacia vera shells for postprandial hyperglycaemia management.
| العنوان: | From waste to bioactive compounds: A response surface methodology approach to extract antioxidants from Pistacia vera shells for postprandial hyperglycaemia management. |
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| المؤلفون: | Elisabetta Maccarronello A; University of Catania, Department of Chemical Sciences, Viale A. Doria 6, 95125 Catania, Italy., Cardullo N; University of Catania, Department of Chemical Sciences, Viale A. Doria 6, 95125 Catania, Italy., Margarida Silva A; REQUIMTE/LAQV, ISEP, Polytechnic of Porto, Rua Dr. António Bernardino de Almeida, 4249-015 Porto, Portugal., Di Francesco A; University of Catania, Department of Chemical Sciences, Viale A. Doria 6, 95125 Catania, Italy., Costa PC; UCIBIO, Applied Molecular Biosciences Unit, MedTech-Laboratory of Pharmaceutical Technology, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal; Associate Laboratory i4HB - Institute for Health and Bioeconomy, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal., Rodrigues F; REQUIMTE/LAQV, ISEP, Polytechnic of Porto, Rua Dr. António Bernardino de Almeida, 4249-015 Porto, Portugal. Electronic address: francisca.rodrigues@graq.isep.ipp.pt., Muccilli V; University of Catania, Department of Chemical Sciences, Viale A. Doria 6, 95125 Catania, Italy. Electronic address: vera.muccilli@unict.it. |
| المصدر: | Food chemistry [Food Chem] 2024 Jun 15; Vol. 443, pp. 138504. Date of Electronic Publication: 2024 Jan 21. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 7702639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7072 (Electronic) Linking ISSN: 03088146 NLM ISO Abbreviation: Food Chem Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Barking : Elsevier Applied Science Publishers Original Publication: Barking, Eng., Applied Science Publishers. |
| مواضيع طبية MeSH: | Diabetes Mellitus, Type 2* , Pistacia* , Hyperglycemia*/drug therapy, Humans ; Antioxidants/pharmacology ; Plant Extracts/pharmacology ; Reactive Oxygen Species ; Caco-2 Cells |
| مستخلص: | Pistacia vera shells, an abundant agricultural by-product, are a rich source of undiscovered bioactive compounds. This study employed a response surface methodology (RSM) approach to optimize the microwave-assisted extraction of antioxidants. The highest total phenolic content, and antioxidant activity were achieved under the optimized extraction conditions (20 % ethanol, 1000 W, 135 s, and solvent-to-solid ratio of 27 mL/g). The resulting extract (OPVS-E) included gallic acid derivatives, hydrolysable tannins, flavonoids, fatty acids, and anacardic acids. Remarkably, OPVS-E displayed potent inhibitory activity against α-amylase (IC Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Antioxidant; HPLC-MS; Microwave-assisted extraction; Response surface methodology; α-amylase inhibition; α-glucosidase inhibition |
| المشرفين على المادة: | 0 (Antioxidants) 0 (Plant Extracts) 0 (Reactive Oxygen Species) |
| تواريخ الأحداث: | Date Created: 20240203 Date Completed: 20240227 Latest Revision: 20240227 |
| رمز التحديث: | 20240227 |
| DOI: | 10.1016/j.foodchem.2024.138504 |
| PMID: | 38309024 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1873-7072 |
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| DOI: | 10.1016/j.foodchem.2024.138504 |