دورية أكاديمية
أعرض في EDS

Farm animal exposure, respiratory illnesses, and nasal cell gene expression.

التفاصيل البيبلوغرافية
العنوان: Farm animal exposure, respiratory illnesses, and nasal cell gene expression.
المؤلفون: Brownell J; Department of Pediatrics, University of Wisconsin-Madison, Madison, Wis., Lee KE; Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, Wis., Chasman D; Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, Wis; Department of Obstetrics and Gynecology, University of Wisconsin-Madison, Madison, Wis., Gangnon R; Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, Wis., Bendixsen CG; National Farm Medicine Center, Marshfield Clinic Research Institute, Marshfield, Wis., Barnes K; National Farm Medicine Center, Marshfield Clinic Research Institute, Marshfield, Wis., Grindle K; Department of Pediatrics, University of Wisconsin-Madison, Madison, Wis., Pappas T; Department of Pediatrics, University of Wisconsin-Madison, Madison, Wis., Bochkov YA; Department of Pediatrics, University of Wisconsin-Madison, Madison, Wis., Dresen A; Department of Pediatrics, University of Wisconsin-Madison, Madison, Wis., Hou C; Department of Statistics, University of Wisconsin-Madison, Madison., Haslam DB; Department of Pediatrics, University of Cincinnati, Cincinnati, Ohio., Seroogy CM; Department of Pediatrics, University of Wisconsin-Madison, Madison, Wis., Ong IM; Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, Wis; Department of Obstetrics and Gynecology, University of Wisconsin-Madison, Madison, Wis., Gern JE; Department of Pediatrics, University of Wisconsin-Madison, Madison, Wis. Electronic address: gern@medicine.wisc.edu.
المصدر: The Journal of allergy and clinical immunology [J Allergy Clin Immunol] 2024 Jun; Vol. 153 (6), pp. 1647-1654. Date of Electronic Publication: 2024 Feb 02.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Mosby Country of Publication: United States NLM ID: 1275002 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-6825 (Electronic) Linking ISSN: 00916749 NLM ISO Abbreviation: J Allergy Clin Immunol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: St Louis, Mosby.
مواضيع طبية MeSH: Environmental Exposure*/adverse effects , Nasal Mucosa*/immunology , Respiratory Tract Diseases*/immunology , Respiratory Tract Diseases*/epidemiology , Respiratory Tract Diseases*/genetics , Farms*, Humans ; Female ; Animals ; Male ; Infant ; Child, Preschool ; Animals, Domestic/immunology ; Infant, Newborn ; Wisconsin/epidemiology
مستخلص: Background: Farm exposures in early life reduce the risks for childhood allergic diseases and asthma. There is less information about how farm exposures relate to respiratory illnesses and mucosal immune development.
Objective: We hypothesized that children raised in farm environments have a lower incidence of respiratory illnesses over the first 2 years of life than nonfarm children. We also analyzed whether farm exposures or respiratory illnesses were related to patterns of nasal cell gene expression.
Methods: The Wisconsin Infant Study Cohort included farm (n = 156) and nonfarm (n = 155) families with children followed to age 2 years. Parents reported prenatal farm and other environmental exposures. Illness frequency and severity were assessed using illness diaries and periodic surveys. Nasopharyngeal cell gene expression in a subset of 64 children at age 2 years was compared to farm exposure and respiratory illness history.
Results: Farm versus nonfarm children had nominally lower rates of respiratory illnesses (rate ratio 0.82 [95% CI, 0.69, 0.97]) with a stepwise reduction in illness rates in children exposed to 0, 1, or ≥2 animal species, but these trends were nonsignificant in a multivariable model. Farm exposures and preceding respiratory illnesses were positively related to nasal cell gene signatures for mononuclear cells and innate and antimicrobial responses.
Conclusions: Maternal and infant exposure to farms and farm animals was associated with nonsignificant trends for reduced respiratory illnesses. Nasal cell gene expression in a subset of children suggests that farm exposures and respiratory illnesses in early life are associated with distinct patterns of mucosal immune expression.
(Copyright © 2024 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.)
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معلومات مُعتمدة: KL2 TR002374 United States TR NCATS NIH HHS; U19 AI104317 United States AI NIAID NIH HHS; UH3 OD023282 United States OD NIH HHS; UL1 TR002373 United States TR NCATS NIH HHS
فهرسة مساهمة: Keywords: Farm; children; gene expression; nasal epithelial cells; respiratory illness; virus
تواريخ الأحداث: Date Created: 20240203 Date Completed: 20240607 Latest Revision: 20240610
رمز التحديث: 20240610
مُعرف محوري في PubMed: PMC11162314
DOI: 10.1016/j.jaci.2024.01.019
PMID: 38309597
قاعدة البيانات: MEDLINE
الوصف
تدمد:1097-6825
DOI:10.1016/j.jaci.2024.01.019