دورية أكاديمية

Dual-energy computed tomography for evaluating nodal staging in lung adenocarcinoma: correlation with surgical pathology.

التفاصيل البيبلوغرافية
العنوان: Dual-energy computed tomography for evaluating nodal staging in lung adenocarcinoma: correlation with surgical pathology.
المؤلفون: Huang HC; Department of Medical Imaging, Taipei City Hospital, Yangming Branch, No. 105, Yusheng St., Shilin Dist., Taipei City, 111024, Taiwan.; Department of Medical Imaging, National Taiwan University Hospital and National Taiwan University College of Medicine, No.7, Chung Shan S. Rd., Zhongzheng Dist., Taipei City, 100225, Taiwan., Huang YS; Department of Medical Imaging, National Taiwan University Hospital and National Taiwan University College of Medicine, No.7, Chung Shan S. Rd., Zhongzheng Dist., Taipei City, 100225, Taiwan., Chang YC; Department of Medical Imaging, National Taiwan University Hospital and National Taiwan University College of Medicine, No.7, Chung Shan S. Rd., Zhongzheng Dist., Taipei City, 100225, Taiwan., Shih JY; Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, No.7, Chung Shan S. Rd., Zhongzheng Dist., Taipei City, 100225, Taiwan., Chen JS; Department of Surgery, National Taiwan University Hospital and National Taiwan University College of Medicine, No.7, Chung Shan S. Rd., Zhongzheng Dist., Taipei City, 100225, Taiwan., Chang YC; Department of Medical Imaging, National Taiwan University Hospital and National Taiwan University College of Medicine, No.7, Chung Shan S. Rd., Zhongzheng Dist., Taipei City, 100225, Taiwan., Wang TC; Department of Medical Imaging, Taipei City Hospital, Yangming Branch, No. 105, Yusheng St., Shilin Dist., Taipei City, 111024, Taiwan. tehchenwang@gmail.com.
المصدر: Japanese journal of radiology [Jpn J Radiol] 2024 May; Vol. 42 (5), pp. 468-475. Date of Electronic Publication: 2024 Feb 05.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer Country of Publication: Japan NLM ID: 101490689 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1867-108X (Electronic) Linking ISSN: 18671071 NLM ISO Abbreviation: Jpn J Radiol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Tokyo : Springer
مواضيع طبية MeSH: Lung Neoplasms*/diagnostic imaging , Lung Neoplasms*/pathology , Tomography, X-Ray Computed*/methods , Adenocarcinoma of Lung*/diagnostic imaging , Adenocarcinoma of Lung*/pathology , Adenocarcinoma of Lung*/surgery , Radiography, Dual-Energy Scanned Projection*/methods , Neoplasm Staging* , Lymphatic Metastasis*/diagnostic imaging , Lymph Nodes*/diagnostic imaging , Lymph Nodes*/pathology, Humans ; Male ; Female ; Middle Aged ; Sensitivity and Specificity ; Aged ; Contrast Media ; Retrospective Studies
مستخلص: Purpose: To ascertain the performance of dual-energy CT (DECT) with iodine quantification in differentiating malignant mediastinal and hilar lymph nodes (LNs) from benign ones, focusing on patients with lung adenocarcinoma.
Materials and Methods: In this study, patients with suspected lung cancer received a preoperative contrast-enhanced DECT scan from Jun 2018 to Dec 2020. Quantitative DECT parameters and the size were compared between metastatic and benign LNs. Their diagnostic performances were analyzed by the ROC curves and compared by using the two-sample t test.
Results: 72 patients (23 men, 49 women; mean age 62.5 ± 10.1 years) fulfilled the inclusion criteria. A total of 98 LNs (67 benign, 31 metastatic) were analyzed. The iodine concentration normalized by muscle (NIC muscle ) was significantly higher (P < 0.001) in metastatic LNs (4.79 ± 1.70) than in benign ones (3.00 ± 1.45). The optimal threshold of NIC muscle was 3.44, which yielded AUC: 0.798, sensitivity: 83.9%, specificity: 73.1%, accuracy: 76.5%, respectively. Applying the established size parameters with 10 mm as the threshold yielded AUC: 0.600, sensitivity: 29.0%, specificity: 91.0%, accuracy: 71.4%, respectively. The diagnostic performance of NIC muscle was significantly better (P = 0.007) than the performance obtained using the established size parameters.
Conclusions: For lung adenocarcinoma, the quantitative measurement of NIC muscle derived from DECT is useful for differentiating benign and metastatic mediastinal and hilar LNs before surgical intervention.
(© 2024. The Author(s) under exclusive licence to Japan Radiological Society.)
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معلومات مُعتمدة: MOST 109-2221-E-002 -035 -MY3 Ministry of Science and Technology, Taiwan
فهرسة مساهمة: Keywords: Adenocarcinoma of lung; Dual-energy computed tomography; Iodine concentration; Lymph node metastases; Spectral computed tomography
المشرفين على المادة: 0 (Contrast Media)
تواريخ الأحداث: Date Created: 20240204 Date Completed: 20240428 Latest Revision: 20240428
رمز التحديث: 20240429
DOI: 10.1007/s11604-023-01525-9
PMID: 38311704
قاعدة البيانات: MEDLINE
الوصف
تدمد:1867-108X
DOI:10.1007/s11604-023-01525-9