دورية أكاديمية
Comparison of the effect of topical triamcinolone 0.1% cream with sulfur 2.0% cream in the treatment of patients with hand eczema: A randomized controlled trial.
| العنوان: | Comparison of the effect of topical triamcinolone 0.1% cream with sulfur 2.0% cream in the treatment of patients with hand eczema: A randomized controlled trial. |
|---|---|
| المؤلفون: | Asilian A; Department of Dermatology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.; Department of Dermatology, Skin and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran., Mohammadian P; Department of Dermatology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.; Department of Dermatology, Skin and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran., Hosseini SM; Department of Biostatistics & Epidemiology, School of Public Health, Isfahan University of Medical Sciences, Isfahan, Iran., Heidaripour F; Sina Daru International, Suba Laboratory, Tehran, Iran., Yekta A; Sina Daru International, Suba Laboratory, Tehran, Iran., Nateghi MR; Sarem Academy of Sciences, Sarem Hospital, Tehran, Iran. |
| المصدر: | Journal of cosmetic dermatology [J Cosmet Dermatol] 2024 May; Vol. 23 (5), pp. 1753-1757. Date of Electronic Publication: 2024 Feb 04. |
| نوع المنشور: | Journal Article; Randomized Controlled Trial; Comparative Study |
| اللغة: | English |
| بيانات الدورية: | Publisher: Blackwell Science Country of Publication: England NLM ID: 101130964 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1473-2165 (Electronic) Linking ISSN: 14732130 NLM ISO Abbreviation: J Cosmet Dermatol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Oxford, UK : Blackwell Science, c2002- |
| مواضيع طبية MeSH: | Eczema*/drug therapy , Hand Dermatoses*/drug therapy , Skin Cream*/administration & dosage , Skin Cream*/adverse effects , Severity of Illness Index* , Triamcinolone*/administration & dosage , Triamcinolone*/adverse effects , Sulfur*/administration & dosage , Sulfur*/adverse effects, Humans ; Male ; Female ; Adult ; Middle Aged ; Treatment Outcome ; Young Adult ; Pruritus/drug therapy ; Pruritus/etiology ; Administration, Cutaneous ; Glucocorticoids/administration & dosage ; Glucocorticoids/adverse effects |
| مستخلص: | Background: Hand eczema (HE) is a common and heterogeneous condition. It has a wide range of etiologies and clinical manifestations. In this study the efficacy of triamcinolone 0.1% cream and sulfur 2% creams was compared in treating patients with HE. Methods: This randomized, triple-blind clinical trial was performed on 70 patients with HE (including 70 right and 70 left hands). In this study, two creams were used including triamcinolone 0.1% and sulfur 2.0%. Patients were treated with these creams twice a day (once in every 12 h) for 4 weeks. Follow-up was 4 weeks after treatment. Hand Eczema Severity Index (HECSI), itching, dryness, burning sensation, and erythema scores were collected three times during the study and compared between treatment regimens. Results: Findings showed that both triamcinolone (0.1%) and sulfur (2.0%) creams could significantly reduce the scores of HECSI, itching, dryness, burning sensation, and erythema, and the therapeutic effects lasted for at least 4 weeks after cessation of topical treatment. Conclusion: Topical sulfur cream (2.0%) is as effective as triamcinolone (0.1%) cream in treatment of HE without any prominent adverse reactions. (© 2024 The Authors. Journal of Cosmetic Dermatology published by Wiley Periodicals LLC.) |
| References: | Agner T, Andersen KE, Brandao FM, et al. Hand eczema severity and quality of life: a cross‐sectional, multicentre study of hand eczema patients. Contact Dermatitis. 2008;59:43‐47. Dubin C, Del Duca E, Guttman‐Yassky E. Drugs for the treatment of chronic hand eczema: successes and key challenges. Ther Clin Risk Manag. 2020;16:1319‐1332. Elsner P, Agner T. Hand eczema: treatment. J Eur Acad Dermatol Venereol. 2020;34:13‐21. Funke U, Fartasch M, Diepgen TL. Incidence of work‐related hand eczema during apprenticeship: first results of a prospective cohort study in the car industry. Contact Dermatitis. 2001;44:166‐172. Diepgen TL, Agner T, Aberer W, et al. Management of chronic hand eczema. Contact Dermatitis. 2007;57:203‐210. Lantinga H, Nater J, Coenraads P. Prevalence, incidence and course of eczema on the hands and forearms in a sample of the general population. Contact Dermatitis. 1984;10:135‐139. Oosterhaven J, Schuttelaar M. Testing the hand eczema severity index. Br J Dermatol. 2020;182:e144. Held E, Skoet R, Johansen J, Agner T. The hand eczema severity index (HECSI): a scoring system for clinical assessment of hand eczema. A study of inter‐and intraobserver reliability. Br J Dermatol. 2005;152:302‐307. Barrett A, Hahn‐Pedersen J, Kragh N, Evans E, Gnanasakthy A. Patient‐reported outcome measures in atopic dermatitis and chronic hand eczema in adults. Patient. 2019;12:445‐459. Lee GR, Maarouf M, Hendricks AK, Lee DE, Shi VY. Current and emerging therapies for hand eczema. Dermatol Ther. 2019;32:e12840. Christoffers WA, Politiek K, Coenraads PJ, van der Schaft J, de Bruin‐Weller M, Schuttelaar M. Drug survival of cyclosporine in the treatment of hand eczema: a multicentre, daily use study. J Eur Acad Dermatol Venereol. 2016;30:63‐66. Granlund H, Erkko P, Eriksson E, Reitamo S. Comparison of cyclosporine and topical betamethasone‐17, 21‐dipropionate in the treatment of severe chronic hand eczema. Acta Derm Venereol. 1996;76:371‐376. Gooderham M, Lynde CW, Papp K, et al. Review of systemic treatment options for adult atopic dermatitis. J Cutan Med Surg. 2017;21:31‐39. Siegfried EC, Jaworski JC, Kaiser JD, Hebert AA. Systematic review of published trials: long‐term safety of topical corticosteroids and topical calcineurin inhibitors in pediatric patients with atopic dermatitis. BMC Pediatr. 2016;16:1‐15. Lin AN, Reimer RJ, Carter DM. Sulfur revisited. J Am Acad Dermatol. 1988;18:553‐558. Okouchi S. Effects of sulfur hot spring water with reductive characteristic on the skin. The Proceedings of the 62nd General Assembly and International Thermalism/Scientific Congress of the world Federation of hydrotherapy and Climatotherapy at Yokohama, Japan, 2009 2009. Gupta AK, Nicol K. The use of sulfur in dermatology. J Drugs Dermatol. 2004;3:427‐431. Draelos ZD. The multifunctionality of 10% sodium sulfacetamide, 5% sulfur emollient foam in the treatment of inflammatory facial dermatoses. J Drugs Dermatol. 2010;9:234‐236. Hashem NM, Hosny AE‐DM, Abdelrahman AA, Zakeer S. Antimicrobial activities encountered by sulfur nanoparticles combating staphylococcal species harboring sccmecA recovered from acne vulgaris. AIMS Microbiol. 2021;7:481‐498. Avila‐Romay A, Alvarez‐Franco M, Ruiz‐Maldonado R. Therapeutic efficacy, secondary effects, and patient acceptability of 10% sulfur in either pork fat or cold cream for the treatment of scabies. Pediatr Dermatol. 1991;8:64‐66. Wilkinson R, Adam J, Murray J, Craig GE. Benzoyl peroxide and sulfur: foundation for acne management. Can Med Assoc J. 1966;95:28‐29. Coenraads P‐J. Hand eczema is common and multifactorial. J Invest Dermatol. 2007;127:1568‐1570. Moberg C, Alderling M, Meding B. Hand eczema and quality of life: a population‐based study. Br J Dermatol. 2009;161:397‐403. Cheng J, Facheris P, Ungar B, Guttman‐Yassky E. Current emerging and investigational drugs for the treatment of chronic hand eczema. Expert Opin Investig Drugs. 2022;31:843‐853. Blom I, Hornmark A. Topical treatment with sulfur 10 per cent for rosacea. Acta Derm Venereol. 1984;64:358‐359. Lee DY, Li H, Lim HJ, Lee HJ, Jeon R, Ryu J‐H. Anti‐inflammatory activity of sulfur‐containing compounds from garlic. J Med Food. 2012;15:992‐999. Bethesda M. Drugs and Lactation Database (LactMed®). National Institute of Child Health and Human Development; 2006. |
| فهرسة مساهمة: | Keywords: hand eczema; hand eczema severity index; randomized controlled trial; sulfur cream; triamcinolone cream |
| المشرفين على المادة: | 1ZK20VI6TY (Triamcinolone) 70FD1KFU70 (Sulfur) 0 (Glucocorticoids) |
| تواريخ الأحداث: | Date Created: 20240205 Date Completed: 20240424 Latest Revision: 20240508 |
| رمز التحديث: | 20240509 |
| DOI: | 10.1111/jocd.16208 |
| PMID: | 38311842 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1473-2165 |
|---|---|
| DOI: | 10.1111/jocd.16208 |