دورية أكاديمية
A Retrospective Cohort Study to Evaluate the Outcomes of HIV-Associated High-Grade B-Cell Non-Hodgkin Lymphoma (NHL) Treated with Dose Adjusted EPOCH (+/-R) Regimen.
| العنوان: | A Retrospective Cohort Study to Evaluate the Outcomes of HIV-Associated High-Grade B-Cell Non-Hodgkin Lymphoma (NHL) Treated with Dose Adjusted EPOCH (+/-R) Regimen. |
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| المؤلفون: | Thorat J; Department of Medical Oncology, Tata Memorial Centre, Tata Memorial Hospital, Homi Bhabha National Institute, Room-21, Main Building, E. Borges Road, Parel, Mumbai, 400012 India., Sengar M; Department of Medical Oncology, Tata Memorial Centre, Tata Memorial Hospital, Homi Bhabha National Institute, Room-21, Main Building, E. Borges Road, Parel, Mumbai, 400012 India., Chanana R; Department of Medical Oncology, Tata Memorial Centre, Tata Memorial Hospital, Homi Bhabha National Institute, Room-21, Main Building, E. Borges Road, Parel, Mumbai, 400012 India., Kapoor A; Department of Medical Oncology, Tata Memorial Centre, Tata Memorial Hospital, Homi Bhabha National Institute, Room-21, Main Building, E. Borges Road, Parel, Mumbai, 400012 India., Singh A; Department of Medical Oncology, Tata Memorial Centre, Tata Memorial Hospital, Homi Bhabha National Institute, Room-21, Main Building, E. Borges Road, Parel, Mumbai, 400012 India., Bonda A; Department of Medical Oncology, Tata Memorial Centre, Tata Memorial Hospital, Homi Bhabha National Institute, Room-21, Main Building, E. Borges Road, Parel, Mumbai, 400012 India., Menon H; Department of Medical Oncology, Cytecare Cancer Hospital, Bengaluru, India., Bagal B; Department of Medical Oncology, Tata Memorial Centre, Tata Memorial Hospital, Homi Bhabha National Institute, Room-21, Main Building, E. Borges Road, Parel, Mumbai, 400012 India., Laskar S; Department of Radiation Oncology, Tata Memorial Centre, Mumbai, India., Khanna N; Department of Radiation Oncology, Tata Memorial Centre, Mumbai, India., Goda JS; Department of Radiation Oncology, Tata Memorial Centre, Mumbai, India., Sridhar E; Department of Pathology, Tata Memorial Centre, Mumbai, India., Gujral S; Department of Pathology, Tata Memorial Centre, Mumbai, India., Agarwal A; Department of Nuclear Medicine, Tata Memorial Centre, Mumbai, India., Sawant S; Department of General Medicine, Tata Memorial Centre, Mumbai, India., Daddi A; Department of General Medicine, Tata Memorial Centre, Mumbai, India., Shet T; Department of Pathology, Tata Memorial Centre, Mumbai, India., Ghandade N; Department of Clinical Research Secretariat, Tata Memorial Centre, Mumbai, India., Jain H; Department of Medical Oncology, Tata Memorial Centre, Tata Memorial Hospital, Homi Bhabha National Institute, Room-21, Main Building, E. Borges Road, Parel, Mumbai, 400012 India. |
| المصدر: | Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion [Indian J Hematol Blood Transfus] 2024 Jan; Vol. 40 (1), pp. 36-42. Date of Electronic Publication: 2023 Apr 21. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Indian Society of Hematology and Blood Transfusion Country of Publication: India NLM ID: 9425818 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0971-4502 (Print) Linking ISSN: 09714502 NLM ISO Abbreviation: Indian J Hematol Blood Transfus Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Publication: [Mumbai] : Springer India : Indian Society of Hematology and Blood Transfusion Original Publication: Bombay : Indian Society of Hematology and Blood Transfusion |
| مستخلص: | High-grade B-cell NHL's are more common in seropositive patients. They are biologically different from their seronegative counterparts. We report our analysis on our cohort of patients who were treated with DA-EPOCH(+/-R). We retrospectively analyzed treatment-naïve HIV-associated High-grade B-cell NHL patients (aged ≥ 18) treated with DA-EPOCH(+/-R) regimen from 2011 to 2015. Descriptive statistics were summarized with median and range; survival outcomes were analyzed with Kaplan-Meier method. The cohort comprised of 40 patients [DLBCL(19), Burkitt's Lymphoma(16), High-grade B-Cell Lymphoma-Unclassifiable(09), and Plasmablastic Lymphoma(01)] and the median CD4 + T cell count was 202/mm 3 . CNS prophylaxis was administered with intrathecal methotrexate to 90% of patients. With a median follow-up of 72 months, an estimated 5-year OS was 82.5%, and 5-PFS was 77.5%. There were 9 deaths, and 9 patients had progression. At least 4 cycles of chemotherapy were administered to 35 (93%) patients, with 28 (70%) receiving 6 cycles. Grade 3-4 toxicities were seen in 33 (83%) patients- febrile neutropenia (65%) being the most common followed by mucositis (25%) and peripheral neuropathy (13%). There was no difference in survival based on IPI, CD 4 + T cell count, CDI, or duration of HIV. DA-EPOCH(+/-R) is a highly effective regimen in seropositive high-grade B-cell lymphoma, even in the presence of adverse features. Supplementary Information: The online version contains supplementary material available at 10.1007/s12288-023-01652-3. Competing Interests: Conflicts of interestThe authors whose names are listed certify that they have no affiliations with or involvement in any organization or entity with any financial interest, or non-financial interest in the subject matter or materials discussed in this manuscript. (© The Author(s), under exclusive licence to Indian Society of Hematology and Blood Transfusion 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.) |
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| فهرسة مساهمة: | Keywords: DA-R EPOCH; HIV; Non-Hodgkin lymphoma; Seropositive lymphoma |
| تواريخ الأحداث: | Date Created: 20240205 Latest Revision: 20240206 |
| رمز التحديث: | 20240206 |
| مُعرف محوري في PubMed: | PMC10830987 |
| DOI: | 10.1007/s12288-023-01652-3 |
| PMID: | 38312196 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 0971-4502 |
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| DOI: | 10.1007/s12288-023-01652-3 |