دورية أكاديمية
أعرض في EDS

Collinsella aerofaciens linked with increased ethanol production and liver inflammation contribute to the pathophysiology of NAFLD.

التفاصيل البيبلوغرافية
العنوان: Collinsella aerofaciens linked with increased ethanol production and liver inflammation contribute to the pathophysiology of NAFLD.
المؤلفون: Purohit A; Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad 121004, India., Kandiyal B; Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad 121004, India., Kumar S; Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad 121004, India., Pragasam AK; Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad 121004, India., Kamboj P; Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad 121004, India., Talukdar D; Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad 121004, India., Verma J; Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad 121004, India., Sharma V; Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad 121004, India., Sarkar S; Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad 121004, India., Mahajan D; Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad 121004, India., Yadav R; Department of Pathology, All India Institute of Medical Sciences, New Delhi 110029, India., Ahmed R; Translational Health Group, International Centre for Genetic Engineering and Biotechnology, New Delhi 110067, India., Nanda R; Translational Health Group, International Centre for Genetic Engineering and Biotechnology, New Delhi 110067, India., Dikshit M; Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad 121004, India., Banerjee SK; Department of Biotechnology, National Institute of Pharmaceutical Education and Research (NIPER-Guwahati), Changsari, Guwahati, Assam 781101, India., Shalimar; Department of Gastroenterology and Human Nutrition, All India Institute of Medical Sciences, New Delhi 110029, India., Das B; Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad 121004, India.
المصدر: IScience [iScience] 2023 Dec 26; Vol. 27 (2), pp. 108764. Date of Electronic Publication: 2023 Dec 26 (Print Publication: 2024).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101724038 Publication Model: eCollection Cited Medium: Internet ISSN: 2589-0042 (Electronic) Linking ISSN: 25890042 NLM ISO Abbreviation: iScience Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [Cambridge, MA] : Cell Press, [2018]-
مستخلص: Non-alcoholic fatty liver disease (NAFLD) is an emerging global health problem and a potential risk factor for metabolic diseases. The bidirectional interactions between liver and gut made dysbiotic gut microbiome one of the key risk factors for NAFLD. In this study, we reported an increased abundance of Collinsella aerofaciens in the gut of obese and NASH patients living in India. We isolated C. aerofaciens from the fecal samples of biopsy-proven NASH patients and observed that their genome is enriched with carbohydrate metabolism, fatty acid biosynthesis, and pro-inflammatory functions and have the potency to increase ethanol level in blood. An animal study indicated that mice supplemented with C. aerofaciens had increased levels of circulatory ethanol, high levels of hepatic hydroxyproline, triglyceride, and inflammation in the liver. The present findings indicate that perturbation in the gut microbiome composition is a key risk factor for NAFLD.
Competing Interests: No potential conflict of interest was reported by any of the author(s) listed in this manuscript.
(© 2023 The Author(s).)
References: Nat Commun. 2023 Jun 3;14(1):3215. (PMID: 37270557)
Gastroenterology. 2018 Dec;155(6):1828-1837.e2. (PMID: 30144434)
Annu Rev Microbiol. 2023 Sep 15;77:479-497. (PMID: 37339735)
Nat Rev Gastroenterol Hepatol. 2018 Jul;15(7):397-411. (PMID: 29748586)
Bioinformatics. 2018 Sep 1;34(17):i884-i890. (PMID: 30423086)
J Clin Gastroenterol. 2011 Nov;45 Suppl:S128-32. (PMID: 21992951)
Nucleic Acids Res. 2019 Jul 2;47(W1):W256-W259. (PMID: 30931475)
Microbiome. 2021 Jun 14;9(1):140. (PMID: 34127070)
Exp Ther Med. 2022 Jul 28;24(3):598. (PMID: 35949337)
Genome Announc. 2017 Nov 22;5(47):. (PMID: 29167267)
Hepatology. 2013 Feb;57(2):601-9. (PMID: 23055155)
Bioinformatics. 2014 Jul 15;30(14):2068-9. (PMID: 24642063)
Science. 2013 Sep 6;341(6150):1241214. (PMID: 24009397)
Genome Med. 2016 Apr 21;8(1):43. (PMID: 27102666)
Int J Environ Res Public Health. 2020 Oct 19;17(20):. (PMID: 33086688)
Cell Host Microbe. 2018 Jun 13;23(6):716-724. (PMID: 29902437)
Am J Gastroenterol. 2020 Mar;115(3):340-349. (PMID: 32032073)
Cells. 2022 Oct 27;11(21):. (PMID: 36359786)
Gut Microbes. 2020 May 3;11(3):569-580. (PMID: 31696774)
Bioinformatics. 2014 May 1;30(9):1312-3. (PMID: 24451623)
Yale J Biol Med. 2016 Sep 30;89(3):285-297. (PMID: 27698613)
Nat Rev Gastroenterol Hepatol. 2021 Apr;18(4):223-238. (PMID: 33349658)
Sci Rep. 2018 Jul 4;8(1):10104. (PMID: 29973712)
Hepatobiliary Surg Nutr. 2015 Apr;4(2):109-16. (PMID: 26005677)
Metabolism. 2017 Apr;69:177-187. (PMID: 28285648)
PLoS Comput Biol. 2017 Jun 8;13(6):e1005595. (PMID: 28594827)
PLoS One. 2014 Apr 24;9(4):e95547. (PMID: 24763225)
Front Cell Infect Microbiol. 2020 Nov 24;10:572912. (PMID: 33330122)
Prog Mol Biol Transl Sci. 2022;191(1):53-82. (PMID: 36270682)
Genome Med. 2021 Mar 3;13(1):37. (PMID: 33658058)
BMC Genomics. 2008 Feb 08;9:75. (PMID: 18261238)
Curr Opin Gastroenterol. 2015 Jan;31(1):69-75. (PMID: 25394236)
PeerJ. 2016 Oct 18;4:e2584. (PMID: 27781170)
Gut. 2016 Jul;65(7):1232. (PMID: 26984853)
CA Cancer J Clin. 2017 Jul 8;67(4):326-344. (PMID: 28481406)
Nucleic Acids Res. 2002 Apr 1;30(7):1575-84. (PMID: 11917018)
Cell Metab. 2019 Oct 1;30(4):675-688.e7. (PMID: 31543403)
Nature. 2011 Apr 7;472(7341):57-63. (PMID: 21475195)
Genome Biol. 2012 Apr 16;13(9):R79. (PMID: 23013615)
Biochem Genet. 2021 Aug;59(4):940-965. (PMID: 33599871)
Ann Rheum Dis. 2023 May;82(5):621-629. (PMID: 36627170)
World J Gastrointest Pathophysiol. 2015 Nov 15;6(4):99-109. (PMID: 26600967)
Nat Rev Gastroenterol Hepatol. 2020 May;17(5):279-297. (PMID: 32152478)
Nat Biotechnol. 2019 Aug;37(8):852-857. (PMID: 31341288)
Int J Clin Exp Pathol. 2015 May 01;8(5):5153-60. (PMID: 26191211)
فهرسة مساهمة: Keywords: Human metabolism; Microbiology
تواريخ الأحداث: Date Created: 20240205 Latest Revision: 20240206
رمز التحديث: 20240206
مُعرف محوري في PubMed: PMC10837629
DOI: 10.1016/j.isci.2023.108764
PMID: 38313048
قاعدة البيانات: MEDLINE
الوصف
تدمد:2589-0042
DOI:10.1016/j.isci.2023.108764