دورية أكاديمية
Collinsella aerofaciens linked with increased ethanol production and liver inflammation contribute to the pathophysiology of NAFLD.
العنوان: | Collinsella aerofaciens linked with increased ethanol production and liver inflammation contribute to the pathophysiology of NAFLD. |
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المؤلفون: | Purohit A; Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad 121004, India., Kandiyal B; Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad 121004, India., Kumar S; Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad 121004, India., Pragasam AK; Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad 121004, India., Kamboj P; Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad 121004, India., Talukdar D; Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad 121004, India., Verma J; Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad 121004, India., Sharma V; Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad 121004, India., Sarkar S; Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad 121004, India., Mahajan D; Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad 121004, India., Yadav R; Department of Pathology, All India Institute of Medical Sciences, New Delhi 110029, India., Ahmed R; Translational Health Group, International Centre for Genetic Engineering and Biotechnology, New Delhi 110067, India., Nanda R; Translational Health Group, International Centre for Genetic Engineering and Biotechnology, New Delhi 110067, India., Dikshit M; Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad 121004, India., Banerjee SK; Department of Biotechnology, National Institute of Pharmaceutical Education and Research (NIPER-Guwahati), Changsari, Guwahati, Assam 781101, India., Shalimar; Department of Gastroenterology and Human Nutrition, All India Institute of Medical Sciences, New Delhi 110029, India., Das B; Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad 121004, India. |
المصدر: | IScience [iScience] 2023 Dec 26; Vol. 27 (2), pp. 108764. Date of Electronic Publication: 2023 Dec 26 (Print Publication: 2024). |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Cell Press Country of Publication: United States NLM ID: 101724038 Publication Model: eCollection Cited Medium: Internet ISSN: 2589-0042 (Electronic) Linking ISSN: 25890042 NLM ISO Abbreviation: iScience Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Original Publication: [Cambridge, MA] : Cell Press, [2018]- |
مستخلص: | Non-alcoholic fatty liver disease (NAFLD) is an emerging global health problem and a potential risk factor for metabolic diseases. The bidirectional interactions between liver and gut made dysbiotic gut microbiome one of the key risk factors for NAFLD. In this study, we reported an increased abundance of Collinsella aerofaciens in the gut of obese and NASH patients living in India. We isolated C. aerofaciens from the fecal samples of biopsy-proven NASH patients and observed that their genome is enriched with carbohydrate metabolism, fatty acid biosynthesis, and pro-inflammatory functions and have the potency to increase ethanol level in blood. An animal study indicated that mice supplemented with C. aerofaciens had increased levels of circulatory ethanol, high levels of hepatic hydroxyproline, triglyceride, and inflammation in the liver. The present findings indicate that perturbation in the gut microbiome composition is a key risk factor for NAFLD. Competing Interests: No potential conflict of interest was reported by any of the author(s) listed in this manuscript. (© 2023 The Author(s).) |
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فهرسة مساهمة: | Keywords: Human metabolism; Microbiology |
تواريخ الأحداث: | Date Created: 20240205 Latest Revision: 20240206 |
رمز التحديث: | 20240206 |
مُعرف محوري في PubMed: | PMC10837629 |
DOI: | 10.1016/j.isci.2023.108764 |
PMID: | 38313048 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2589-0042 |
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DOI: | 10.1016/j.isci.2023.108764 |