Clinical Use of Bedside Portable Low-field Brain Magnetic Resonance Imaging in Patients on ECMO: The Results from Multicenter SAFE MRI ECMO Study.
| العنوان: | Clinical Use of Bedside Portable Low-field Brain Magnetic Resonance Imaging in Patients on ECMO: The Results from Multicenter SAFE MRI ECMO Study. |
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| المؤلفون: | Cho SM; Johns Hopkins University School of Medicine., Khanduja S; Johns Hopkins Hospital: Johns Hopkins Medicine., Wilcox C; Johns Hopkins Hospital: Johns Hopkins Medicine., Dinh K; UTHSC: The University of Texas Health Science Center at Houston., Kim J; Johns Hopkins Hospital: Johns Hopkins Medicine., Kang JK; Johns Hopkins Hospital: Johns Hopkins Medicine., Chinedozi ID; Johns Hopkins Hospital: Johns Hopkins Medicine., Darby Z; Johns Hopkins Hospital: Johns Hopkins Medicine., Acton M; Johns Hopkins Hospital: Johns Hopkins Medicine., Rando H; Johns Hopkins Hospital: Johns Hopkins Medicine., Briscoe J; Johns Hopkins Hospital: Johns Hopkins Medicine., Bush E; Johns Hopkins Hospital: Johns Hopkins Medicine., Sair HI; Johns Hopkins Hospital: Johns Hopkins Medicine., Pitts J; Hyperfine Inc., Arlinghaus LR; Hyperfine Inc., Wandji AN; UTHSC: The University of Texas Health Science Center at Houston., Moreno E; UTHSC: The University of Texas Health Science Center at Houston., Torres G; UTHSC: The University of Texas Health Science Center at Houston., Akkanti B; UTHSC: The University of Texas Health Science Center at Houston., Gavito-Higuera J; UTHSC: The University of Texas Health Science Center at Houston., Keller S; Johns Hopkins Hospital: Johns Hopkins Medicine., Choi HA; UTHSC: The University of Texas Health Science Center at Houston., Kim BS; Johns Hopkins Hospital: Johns Hopkins Medicine., Gusdon A; UTHSC: The University of Texas Health Science Center at Houston., Whitman GJ; Johns Hopkins Hospital: Johns Hopkins Medicine. |
| المصدر: | Research square [Res Sq] 2024 Jan 16. Date of Electronic Publication: 2024 Jan 16. |
| نوع المنشور: | Preprint |
| اللغة: | English |
| بيانات الدورية: | Country of Publication: United States NLM ID: 101768035 Publication Model: Electronic Cited Medium: Internet ISSN: 2693-5015 (Electronic) Linking ISSN: 26935015 NLM ISO Abbreviation: Res Sq Subsets: PubMed not MEDLINE |
| مستخلص: | Purpose: Early detection of acute brain injury (ABI) is critical for improving survival for patients with extracorporeal membrane oxygenation (ECMO) support. We aimed to evaluate the safety of ultra-low-field portable MRI (ULF-pMRI) and the frequency and types of ABI observed during ECMO support. Methods: We conducted a multicenter prospective observational study (NCT05469139) at two academic tertiary centers (August 2022-November 2023). Primary outcomes were safety and validation of ULF-pMRI in ECMO, defined as exam completion without adverse events (AEs); secondary outcomes were ABI frequency and type. Results: ULF-pMRI was performed in 50 patients with 34 (68%) on venoarterial (VA)-ECMO (11 central; 23 peripheral) and 16 (32%) with venovenous (VV)-ECMO (9 single lumen; 7 double lumen). All patients were imaged successfully with ULF-pMRI, demonstrating discernible intracranial pathologies with good quality. AEs occurred in 3 (6%) patients (2 minor; 1 serious) without causing significant clinical issues.ABI was observed in ULF-pMRI scans for 22 patients (44%): ischemic stroke (36%), intracranial hemorrhage (6%), and hypoxic-ischemic brain injury (4%). Of 18 patients with both ULF-pMRI and head CT (HCT) within 24 hours, ABI was observed in 9 patients with 10 events: 8 ischemic (8 observed on ULF-oMRI, 4 on HCT) and 2 hemorrhagic (1 observed on ULF-pMRI, 2 on HCT). Conclusions: ULF-pMRI was shown to be safe and valid in ECMO patients across different ECMO cannulation strategies. The incidence of ABI was high, and ULF-pMRI may more sensitive to ischemic ABI than HCT. ULF-pMRI may benefit both clinical care and future studies of ECMO-associated ABI. Competing Interests: Conflicts of Interest/Disclosures All other authors declare that the research was conducted without any commercial or financial relationships that could be construed as a potential conflict of interest. |
| معلومات مُعتمدة: | K23 HL157610 United States HL NHLBI NIH HHS; K23 NS121628 United States NS NINDS NIH HHS; L30 HL165486 United States HL NHLBI NIH HHS; L30 NS119233 United States NS NINDS NIH HHS |
| فهرسة مساهمة: | Keywords: ABI; ECMO; Portable MRI; acute brain injury; critical care; ultra-low-field MRI |
| تواريخ الأحداث: | Date Created: 20240205 Latest Revision: 20240904 |
| رمز التحديث: | 20240904 |
| مُعرف محوري في PubMed: | PMC10836091 |
| DOI: | 10.21203/rs.3.rs-3858221/v1 |
| PMID: | 38313271 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2693-5015 |
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| DOI: | 10.21203/rs.3.rs-3858221/v1 |