دورية أكاديمية
Spontaneous Dynamics of Hippocampal Place Fields in a Model of Combinatorial Competition among Stable Inputs.
| العنوان: | Spontaneous Dynamics of Hippocampal Place Fields in a Model of Combinatorial Competition among Stable Inputs. |
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| المؤلفون: | Savelli F; Department of Neuroscience, Developmental and Regenerative Biology, The University of Texas at San Antonio, San Antonio, Texas 78249 fsavelli.research@gmail.com.; Neurosciences Institute, The University of Texas at San Antonio, San Antonio, Texas 78249.; Brain Health Consortium, The University of Texas at San Antonio, San Antonio, Texas 78249. |
| المصدر: | The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2024 Mar 27; Vol. 44 (13). Date of Electronic Publication: 2024 Mar 27. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Society for Neuroscience Country of Publication: United States NLM ID: 8102140 Publication Model: Electronic Cited Medium: Internet ISSN: 1529-2401 (Electronic) Linking ISSN: 02706474 NLM ISO Abbreviation: J Neurosci Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Washington, DC : Society for Neuroscience Original Publication: [Baltimore, Md.] : The Society, c1981- |
| مواضيع طبية MeSH: | Entorhinal Cortex*/physiology , Grid Cells*, Rats ; Animals ; Models, Neurological ; Hippocampus/physiology ; Neurons/physiology |
| مستخلص: | We present computer simulations illustrating how the plastic integration of spatially stable inputs could contribute to the dynamic character of hippocampal spatial representations. In novel environments of slightly larger size than typical apparatus, the emergence of well-defined place fields in real place cells seems to rely on inputs from normally functioning grid cells. Theoretically, the grid-to-place transformation is possible if a place cell is able to respond selectively to a combination of suitably aligned grids. We previously identified the functional characteristics that allow a synaptic plasticity rule to accomplish this selection by synaptic competition during rat foraging behavior. Here, we show that the synaptic competition can outlast the formation of place fields, contributing to their spatial reorganization over time, when the model is run in larger environments and the topographical/modular organization of grid inputs is taken into account. Co-simulated cells that differ only by their randomly assigned grid inputs display different degrees and kinds of spatial reorganization-ranging from place-field remapping to more subtle in-field changes or lapses in firing. The model predicts a greater number of place fields and propensity for remapping in place cells recorded from more septal regions of the hippocampus and/or in larger environments, motivating future experimental standardization across studies and animal models. In sum, spontaneous remapping could arise from rapid synaptic learning involving inputs that are functionally homogeneous, spatially stable, and minimally stochastic. Competing Interests: The author declares no competing financial interests. (Copyright © 2024 the authors.) |
| التعليقات: | Update of: bioRxiv. 2023 Sep 05;:. (PMID: 37732194) |
| References: | J Exp Biol. 2019 Feb 6;222(Pt Suppl 1):. (PMID: 30728236) J Neurosci. 2019 Mar 27;39(13):2522-2541. (PMID: 30696727) Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):17192-7. (PMID: 17940015) Curr Biol. 2022 Mar 14;32(5):1088-1101.e5. (PMID: 35108522) Proc Natl Acad Sci U S A. 2012 Nov 20;109(47):19462-7. (PMID: 23132944) Neuron. 2023 Aug 2;111(15):2275-2277. (PMID: 37536286) Nature. 1977 Apr 21;266(5604):737-9. (PMID: 195211) Nature. 2012 Dec 6;492(7427):72-8. (PMID: 23222610) Cereb Cortex. 2015 Nov;25(11):4619-27. (PMID: 26048956) Science. 2005 Jul 22;309(5734):619-23. (PMID: 16040709) J Neurophysiol. 2018 Nov 1;120(5):2383-2395. (PMID: 30044689) Nature. 2022 Feb;602(7895):123-128. (PMID: 35022611) Elife. 2017 Jul 25;6:. (PMID: 28742496) PLoS Biol. 2009 Jun 30;7(6):e1000140. (PMID: 19564903) J Neurophysiol. 2002 Oct;88(4):1605-13. (PMID: 12364491) J Neurosci. 1998 Oct 15;18(20):8455-66. (PMID: 9763488) Science. 2011 Apr 29;332(6029):592-5. (PMID: 21527713) Science. 2017 Sep 8;357(6355):1033-1036. (PMID: 28883072) Proc Natl Acad Sci U S A. 2023 Jan 31;120(5):e2212418120. (PMID: 36693104) Hippocampus. 2006;16(12):1026-31. (PMID: 17094145) Science. 2011 Apr 29;332(6029):595-9. (PMID: 21527714) Neuron. 2023 Aug 2;111(15):2348-2356.e5. (PMID: 37315557) J Neurosci. 1992 May;12(5):1945-63. (PMID: 1578279) Hippocampus. 2008;18(12):1270-82. (PMID: 19021262) Elife. 2015 Dec 18;4:. (PMID: 26682652) Hippocampus. 2019 Mar;29(3):284-302. (PMID: 30175425) Hippocampus. 1996;6(6):693-708. (PMID: 9034856) Hippocampus. 2008;18(12):1230-8. (PMID: 18683845) J Comput Neurosci. 2007 Jun;22(3):297-9. (PMID: 17195112) Neuron. 2014 May 21;82(4):789-96. (PMID: 24853939) Elife. 2020 Dec 29;9:. (PMID: 33372892) Wiley Interdiscip Rev Cogn Sci. 2016 Nov;7(6):406-421. (PMID: 27582415) Neuron. 2017 Oct 11;96(2):490-504.e5. (PMID: 29024668) Hippocampus. 2006;16(9):785-94. (PMID: 16921501) Curr Opin Neurobiol. 2019 Feb;54:1-11. (PMID: 30036841) Science. 2004 Aug 27;305(5688):1258-64. (PMID: 15333832) Curr Biol. 2018 Nov 19;28(22):3578-3588.e6. (PMID: 30393037) Brain Res. 1979 Oct 19;175(2):233-45. (PMID: 487154) Neuron. 2004 Apr 22;42(2):283-95. (PMID: 15091343) Nat Neurosci. 2018 Feb;21(2):270-282. (PMID: 29335607) Hippocampus. 1997;7(6):613-23. (PMID: 9443058) J Neurophysiol. 2010 Jun;103(6):3167-83. (PMID: 20357069) Neuron. 2015 Jan 7;85(1):190-201. (PMID: 25569350) Elife. 2022 Aug 30;11:. (PMID: 36040010) Nature. 2005 Aug 11;436(7052):801-6. (PMID: 15965463) Nature. 2015 Feb 12;518(7538):207-12. (PMID: 25673414) Science. 2005 May 6;308(5723):873-6. (PMID: 15879220) Nat Neurosci. 2015 Aug;18(8):1133-42. (PMID: 26167906) Neurobiol Learn Mem. 2012 Nov;98(4):354-60. (PMID: 23084879) J Neurosci. 2000 Nov 1;20(21):8096-102. (PMID: 11050131) Nature. 2022 Apr;604(7904):98-103. (PMID: 35355012) Cell Rep. 2018 Apr 3;23(1):32-38. (PMID: 29617670) Neuron. 2007 Nov 8;56(3):530-40. (PMID: 17988635) Neuroscience. 2002;111(3):553-66. (PMID: 12031343) PLoS One. 2011;6(7):e22349. (PMID: 21789250) Neuron. 2022 Mar 2;110(5):903. (PMID: 35240064) Curr Biol. 2018 Nov 19;28(22):R1306-R1307. (PMID: 30458150) Science. 2008 Dec 19;322(5909):1865-8. (PMID: 19095945) Nat Neurosci. 2014 May;17(5):725-31. (PMID: 24686786) Neuroscience. 2011 Dec 1;197:293-306. (PMID: 21963867) J Neurosci. 2004 Sep 1;24(35):7681-9. (PMID: 15342735) Curr Biol. 2016 Feb 22;26(4):536-41. (PMID: 26853363) Science. 2005 Jun 17;308(5729):1792-4. (PMID: 15961670) Curr Opin Neurobiol. 2022 Oct;76:102609. (PMID: 35939861) Cell. 2023 Feb 2;186(3):543-559.e19. (PMID: 36669484) PLoS One. 2017 Jul 27;12(7):e0181618. (PMID: 28750005) Neuron. 2021 Dec 15;109(24):4036-4049.e5. (PMID: 34710366) Nat Neurosci. 2010 Aug;13(8):995-1002. (PMID: 20639874) Neuron. 2004 Jun 10;42(5):803-15. (PMID: 15182719) Neuron. 2017 Mar 22;93(6):1480-1492.e6. (PMID: 28334610) Neuroscience. 2022 May 1;489:143-164. (PMID: 34756987) Science. 2008 Jul 4;321(5885):140-3. (PMID: 18599792) Nat Neurosci. 2015 Feb;18(2):282-8. (PMID: 25531571) Curr Biol. 2022 Aug 22;32(16):3505-3514.e7. (PMID: 35835121) Neuron. 2017 Feb 8;93(3):677-690.e5. (PMID: 28132828) Hear Res. 2009 Jul;253(1-2):52-9. (PMID: 19303432) J Neurosci. 2007 Mar 21;27(12):3211-29. (PMID: 17376982) Neuron. 2002 Aug 1;35(3):555-66. (PMID: 12165476) Neuron. 2023 Aug 2;111(15):2357-2366.e5. (PMID: 37315556) Nature. 2002 Mar 7;416(6876):90-4. (PMID: 11882899) Nat Neurosci. 2019 Mar;22(3):337-342. (PMID: 30664772) J Neurosci. 1994 Dec;14(12):7347-56. (PMID: 7996180) Hippocampus. 2000;10(1):64-76. (PMID: 10706218) Hippocampus. 1991 Apr;1(2):193-205. (PMID: 1669293) J Neurosci. 1987 Jul;7(7):1951-68. (PMID: 3612226) Physiol Behav. 1999 Aug 1;67(1):57-67. (PMID: 10463629) Elife. 2017 Jan 13;6:. (PMID: 28084992) Nature. 2018 Sep;561(7721):57-62. (PMID: 30158699) Science. 2021 Jul 16;373(6552):343-348. (PMID: 34437154) Science. 1993 Aug 20;261(5124):1055-8. (PMID: 8351520) Cell Rep. 2014 Nov 6;9(3):893-901. (PMID: 25437546) Hippocampus. 2006;16(9):775-84. (PMID: 16921502) Proc Natl Acad Sci U S A. 2012 Oct 23;109(43):17687-92. (PMID: 23045662) J Neurosci. 2008 Oct 29;28(44):11250-62. (PMID: 18971467) J Neurosci. 2009 Aug 5;29(31):9771-7. (PMID: 19657030) Science. 2012 Aug 17;337(6096):849-53. (PMID: 22904011) Neuron. 2021 Mar 17;109(6):1040-1054.e7. (PMID: 33539763) J Neurosci. 2001 Mar 1;21(5):1635-44. (PMID: 11222654) Curr Biol. 2018 May 21;28(10):1499-1508.e4. (PMID: 29706516) Nat Commun. 2020 Sep 11;11(1):4550. (PMID: 32917862) Hippocampus. 2014 Aug;24(8):912-9. (PMID: 24866281) J Neurosci. 2002 Jul 15;22(14):6254-64. (PMID: 12122084) Neuron. 2022 Jun 15;110(12):1978-1992.e6. (PMID: 35447088) J Neurosci. 2004 Jul 21;24(29):6497-506. (PMID: 15269260) Curr Biol. 2021 May 24;31(10):2178-2190.e6. (PMID: 33770492) Proc Natl Acad Sci U S A. 1998 Mar 17;95(6):3182-7. (PMID: 9501237) Hippocampus. 2013 Apr;23(4):253-67. (PMID: 23447419) J Neurosci. 2022 Apr 29;:. (PMID: 35501152) Nature. 2018 Jun;558(7709):292-296. (PMID: 29875406) J Neurophysiol. 2004 Feb;91(2):863-72. (PMID: 14523073) Front Cell Neurosci. 2018 Sep 21;12:332. (PMID: 30297987) Neuron. 2015 Jun 3;86(5):1167-73. (PMID: 26050036) |
| معلومات مُعتمدة: | R01 NS102537 United States NS NINDS NIH HHS |
| فهرسة مساهمة: | Keywords: cognitive map; grid cell; hippocampus; place cell; plasticity; stability |
| تواريخ الأحداث: | Date Created: 20240205 Date Completed: 20240329 Latest Revision: 20240331 |
| رمز التحديث: | 20240331 |
| مُعرف محوري في PubMed: | PMC10977031 |
| DOI: | 10.1523/JNEUROSCI.1663-23.2024 |
| PMID: | 38316560 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1529-2401 |
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| DOI: | 10.1523/JNEUROSCI.1663-23.2024 |