دورية أكاديمية
أعرض في EDS

Circ_0000877 accelerates proliferation and immune escape of non-small cell lung cancer cells by regulating microRNA-637/E2F2 axis.

التفاصيل البيبلوغرافية
العنوان: Circ_0000877 accelerates proliferation and immune escape of non-small cell lung cancer cells by regulating microRNA-637/E2F2 axis.
المؤلفون: Chen T; Department of Pathology, Guangyuan Central Hospital, Guangyuan, Sichuan, China., Li Z; Precision Medical Centre, Guangyuan Central Hospital, Guangyuan, Sichuan, China., Chen J; Department of Pathology, Guangyuan Central Hospital, Guangyuan, Sichuan, China., Xu Z; Guangyuan Central Hospital, Guangyuan, Sichuan, China.
المصدر: Environmental toxicology [Environ Toxicol] 2024 May; Vol. 39 (5), pp. 2980-2992. Date of Electronic Publication: 2024 Feb 05.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: John Wiley & Sons Country of Publication: United States NLM ID: 100885357 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-7278 (Electronic) Linking ISSN: 15204081 NLM ISO Abbreviation: Environ Toxicol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: New York, NY : John Wiley & Sons, c1999-
مواضيع طبية MeSH: Carcinoma, Non-Small-Cell Lung*/genetics , Lung Neoplasms*/genetics , MicroRNAs*/genetics, Humans ; Animals ; Mice ; RNA, Circular/genetics ; Cell Proliferation/genetics ; Cell Line, Tumor ; E2F2 Transcription Factor
مستخلص: Background: Recently, circular RNA (circRNA) has become a vital targeted therapy gene for non-small-cell lung cancer (NSCLC) cells. CircRNA_0000877 (Circ_0000877) has been researched in diffuse large B-cell lymphoma (DLBCL). However, whether circ_0000877 regulated NSCLC cell progression is still poorly investigated. The research attempted to investigate the influence of circ_0000877 in NSCLC.
Methods: Circ_0000877 levels in NSCLC tissues and cell lines were determined applying RT-qPCR. Cell functions were evaluated by CCK-8, EdU, flow cytometry, ELISA, and western blot. Gene interactions were predicted by Cirular RNA interactome database and Target Scan website and certified by dual-luciferase reporter, RIP, and RNA pull-down assays. Finally, mice experimental model was established to explore the effects of circ_0000877 on tumor growth in vivo.
Results: The elevated trend of circ_0000877 expression was discovered in NSCLC tissues compared to para-carcinoma tissues. The clinicopathological data uncovered that up-regulated circ_0000877 was linked to tumor size, differentiation, and TNM stages of NSCLC patients. Knockdown of circ_0000877 inhibited the proliferation, triggered apoptosis, and prohibited immune escape in NSCLC cells. It was certified that miR-637 was directly interacted with circ_0000877 and targeted by E2F2. Overexpressed E2F2 strongly overturned the functions of circ_0000877 knockdown in NSCLC cells. Mice experimental data demonstrated that circ_0000877 knockdown suppressed tumor growth in vivo.
Conclusion: The research demonstrated that circ_0000877 exhibited the promotive effect on NSCLC cells proliferation and immune escape by regulating miR-637/E2F2 axis.
(© 2024 Wiley Periodicals LLC.)
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فهرسة مساهمة: Keywords: E2F2; cell proliferation; circRNA_0000877; miR‐637; non‐small‐cell lung cancer
المشرفين على المادة: 0 (RNA, Circular)
0 (MicroRNAs)
0 (E2F2 protein, human)
0 (E2F2 Transcription Factor)
0 (MIRN637 microRNA, human)
تواريخ الأحداث: Date Created: 20240206 Date Completed: 20240417 Latest Revision: 20240417
رمز التحديث: 20240417
DOI: 10.1002/tox.24172
PMID: 38317501
قاعدة البيانات: MEDLINE
الوصف
تدمد:1522-7278
DOI:10.1002/tox.24172