دورية أكاديمية
Antigen stasis and airway nitrosative stress in human primary ciliary dyskinesia.
العنوان: | Antigen stasis and airway nitrosative stress in human primary ciliary dyskinesia. |
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المؤلفون: | Gaston B; Herman B. Wells Center for Pediatric Research, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, Indiana, United States., Smith LA; Herman B. Wells Center for Pediatric Research, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, Indiana, United States., Davis MD; Herman B. Wells Center for Pediatric Research, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, Indiana, United States., Saunders J; Herman B. Wells Center for Pediatric Research, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, Indiana, United States., Daniels I; Herman B. Wells Center for Pediatric Research, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, Indiana, United States., Horani A; Department of Medicine, Washington University, St. Louis, Missouri, United States., Brody SL; Department of Medicine, Washington University, St. Louis, Missouri, United States., Giddings O; Department of Medicine, Case Western Reserve University, Cleveland, Ohio, United States., Zhao Y; Department of Biostatistics and Health Data Science, Indiana University School of Medicine, Indianapolis, Indiana, United States., Marozkina N; Herman B. Wells Center for Pediatric Research, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, Indiana, United States. |
المصدر: | American journal of physiology. Lung cellular and molecular physiology [Am J Physiol Lung Cell Mol Physiol] 2024 Apr 01; Vol. 326 (4), pp. L468-L476. Date of Electronic Publication: 2024 Feb 06. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901229 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1504 (Electronic) Linking ISSN: 10400605 NLM ISO Abbreviation: Am J Physiol Lung Cell Mol Physiol Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Bethesda, MD : American Physiological Society, c1989- |
مواضيع طبية MeSH: | Ciliary Motility Disorders* , Kartagener Syndrome*/metabolism, Humans ; Hydrogen Peroxide ; Nitrosative Stress ; Breath Tests ; Nitric Oxide/metabolism ; Biomarkers/metabolism |
مستخلص: | Nasal nitric oxide (nNO) is low in most patients with primary ciliary dyskinesia (PCD). Decreased ciliary motion could lead to antigen stasis, increasing oxidant production and NO oxidation in the airways. This could both decrease gas phase NO and increase nitrosative stress. We studied primary airway epithelial cells from healthy controls (HCs) and patients with PCD with several different genotypes. We measured antigen clearance in fenestrated membranes exposed apically to the fluorescently labeled antigen Dermatophagoides pteronyssinus (Derp1-f). We immunoblotted for 3-nitrotyrosine (3-NT) and for oxidative response enzymes. We measured headspace NO above primary airway cells without and with a PCD-causing genotype. We measured nNO and exhaled breath condensate (EBC) H |
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معلومات مُعتمدة: | P01 HL128192 United States HL NHLBI NIH HHS; P01 HL158507 United States HL NHLBI NIH HHS; R01 HL128370 United States HL NHLBI NIH HHS; R01 HL146601 United States HL NHLBI NIH HHS |
فهرسة مساهمة: | Keywords: DUOX1; nasal NO; nitrosative stress; oxidation; primary ciliary dyskinesia |
المشرفين على المادة: | BBX060AN9V (Hydrogen Peroxide) 31C4KY9ESH (Nitric Oxide) 0 (Biomarkers) |
تواريخ الأحداث: | Date Created: 20240206 Date Completed: 20240328 Latest Revision: 20240728 |
رمز التحديث: | 20240728 |
مُعرف محوري في PubMed: | PMC11281798 |
DOI: | 10.1152/ajplung.00208.2022 |
PMID: | 38318660 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1522-1504 |
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DOI: | 10.1152/ajplung.00208.2022 |