دورية أكاديمية
أعرض في EDS

Avastin-Loaded 3D-Printed Alginate Scaffold as an Effective Antiadhesive Barrier to Prevent Postsurgical Adhesion Bands Formation.

التفاصيل البيبلوغرافية
العنوان: Avastin-Loaded 3D-Printed Alginate Scaffold as an Effective Antiadhesive Barrier to Prevent Postsurgical Adhesion Bands Formation.
المؤلفون: Vakilian S; Laboratory for Stem Cell & Regenerative Medicine, Natural and Medical Sciences Research Center, University of Nizwa, Nizwa, PC 616, Oman., Al-Hashmi S; Laboratory for Stem Cell & Regenerative Medicine, Natural and Medical Sciences Research Center, University of Nizwa, Nizwa, PC 616, Oman., Al-Kindi J; Laboratory for Stem Cell & Regenerative Medicine, Natural and Medical Sciences Research Center, University of Nizwa, Nizwa, PC 616, Oman., Al-Fahdi F; Laboratory for Stem Cell & Regenerative Medicine, Natural and Medical Sciences Research Center, University of Nizwa, Nizwa, PC 616, Oman., Al-Wahaibi N; Department of Biomedical Science, College of Medicine & Health Sciences, Sultan Qaboos University, Alkoudh, 123, Oman.; Department of Pathology, College of Medicine & Health Sciences, Sultan Qaboos University, P. O. Box: 35, Alkoudh, 123, Oman., Shalaby A; Department of Pathology, College of Medicine & Health Sciences, Sultan Qaboos University, P. O. Box: 35, Alkoudh, 123, Oman.; Pathology Department, College of Medicine, Mansoura University, Mansoura, Dakahlia, 35516, Egypt., Al-Riyami H; Department of Genetics, College of Medicine and Health Sciences, Sultan Qaboos University, Alkoudh, PC 123, Oman., Al-Harrasi A; Laboratory for Stem Cell & Regenerative Medicine, Natural and Medical Sciences Research Center, University of Nizwa, Nizwa, PC 616, Oman., Jamshidi-Adegani F; Laboratory for Stem Cell & Regenerative Medicine, Natural and Medical Sciences Research Center, University of Nizwa, Nizwa, PC 616, Oman.
المصدر: Macromolecular bioscience [Macromol Biosci] 2024 Jun; Vol. 24 (6), pp. e2300530. Date of Electronic Publication: 2024 Feb 13.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101135941 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1616-5195 (Electronic) Linking ISSN: 16165187 NLM ISO Abbreviation: Macromol Biosci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Weinheim, Germany : Wiley-VCH, c2001-
مواضيع طبية MeSH: Alginates*/chemistry , Alginates*/pharmacology , Printing, Three-Dimensional* , Tissue Scaffolds*/chemistry , Bevacizumab*/pharmacology , Bevacizumab*/chemistry , Vascular Endothelial Growth Factor A*/metabolism, Tissue Adhesions/prevention & control ; Animals ; Rats ; Postoperative Complications/prevention & control ; Humans ; Hydrogels/chemistry ; Hydrogels/pharmacology
مستخلص: Postoperative adhesion can cause complications, such as pain and organ blockage, in the abdominal regions. To address this issue, surgical techniques and antiadhesive treatments are applied. Given the significant role of vascularization in adhesion band formation, Avastin (Ava) that targets vascular endothelial growth factor (VEGF) can be applied to prevent peritoneal adhesion bands. Moreover, Alginate (Alg), a natural polysaccharide, is a promising physical barrier to prevent adhesion bands. Incorporating Ava into Alg hydrogel in a form of 3D-printed scaffold (Alg/Ava) has potential to suppress inflammation and angiogenesis, leading to reduce peritoneal adhesion bands. Following physical, morphological, and biocompatibility evaluations, the efficacy of Alg and Ava alone and their combination in Alg/Ava on the formation of postsurgical adhesions is evaluated. Upon confirming physical stability and sustained release of Ava, the Alg/Ava scaffold effectively diminishes both the extent and strength of adhesion bands. Histopathological examination shows that the reduction in fibrosis and inflammation is responsible for preventing adhesion bands by the Alg/Ava scaffold. Additionally, the cytokine assessment reveals that this is due to the inhibition in the secretion of VEGF and Interleukin 6 suppressing vascularization and inflammatory pathways. This study suggests that a 3D-printed Alg/Ava scaffold has great potential to prevent the postsurgical adhesion bands.
(© 2024 Wiley‐VCH GmbH.)
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معلومات مُعتمدة: BFP/RGP/HSS/21/037 Ministry of Higher Education, Research and Innovation, The Research Council; BFP/GRG/HSS/21/041 Ministry of Higher Education, Research and Innovation, The Research Council; BFP/URG/HSS/21/060 Ministry of Higher Education, Research and Innovation, The Research Council
فهرسة مساهمة: Keywords: 3D‐printing; adhesion bands; alginate; avastin; fibrosis; inflammation; vascularization
المشرفين على المادة: 0 (Alginates)
2S9ZZM9Q9V (Bevacizumab)
0 (Vascular Endothelial Growth Factor A)
0 (Hydrogels)
تواريخ الأحداث: Date Created: 20240206 Date Completed: 20240614 Latest Revision: 20240614
رمز التحديث: 20240614
DOI: 10.1002/mabi.202300530
PMID: 38319279
قاعدة البيانات: MEDLINE
الوصف
تدمد:1616-5195
DOI:10.1002/mabi.202300530