دورية أكاديمية
Effect of high-fat diet on cerebral pathological changes of cerebral small vessel disease in SHR/SP rats.
العنوان: | Effect of high-fat diet on cerebral pathological changes of cerebral small vessel disease in SHR/SP rats. |
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المؤلفون: | Zhang Y; Department of Neurology, Faculty of Medicine, Shimane University, 89-1 Enya-Cho, Izumo, 693-8501, Japan.; Department of Pharmacology, School of Basic Medical Sciences, Heilongjiang University of Chinese Medicine, Harbin, 150040, China., Sheikh AM; Department of Laboratory Medicine, Faculty of Medicine, Shimane University, Izumo, 693-8501, Japan., Tabassum S; Department of Laboratory Medicine, Faculty of Medicine, Shimane University, Izumo, 693-8501, Japan., Iwasa K; Department of Neurology, Faculty of Medicine, Shimane University, 89-1 Enya-Cho, Izumo, 693-8501, Japan., Shibly AZ; Department of Neurology, Faculty of Medicine, Shimane University, 89-1 Enya-Cho, Izumo, 693-8501, Japan.; Department of Biotechnology and Genetic Engineering, Mawlana Bhashani Science and Technology University, Santosh, Tangail, 1902, Bangladesh., Zhou X; Department of Neurology, Faculty of Medicine, Shimane University, 89-1 Enya-Cho, Izumo, 693-8501, Japan.; Department of Neurology, Zhoushan Hospital, Zhoushan, 316004, China., Wang R; Department of Neurology, Faculty of Medicine, Shimane University, 89-1 Enya-Cho, Izumo, 693-8501, Japan., Bhuiya J; Department of Neurology, Faculty of Medicine, Shimane University, 89-1 Enya-Cho, Izumo, 693-8501, Japan., Abdullah FB; Department of Neurology, Faculty of Medicine, Shimane University, 89-1 Enya-Cho, Izumo, 693-8501, Japan., Yano S; Department of Laboratory Medicine, Faculty of Medicine, Shimane University, Izumo, 693-8501, Japan., Aoki Y; Department of Neurology, Faculty of Medicine, Shimane University, 89-1 Enya-Cho, Izumo, 693-8501, Japan., Nagai A; Department of Neurology, Faculty of Medicine, Shimane University, 89-1 Enya-Cho, Izumo, 693-8501, Japan. anagai@med.shimane-u.ac.jp. |
المصدر: | GeroScience [Geroscience] 2024 Aug; Vol. 46 (4), pp. 3779-3800. Date of Electronic Publication: 2024 Feb 06. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Springer International Publishing Country of Publication: Switzerland NLM ID: 101686284 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2509-2723 (Electronic) Linking ISSN: 25092723 NLM ISO Abbreviation: Geroscience Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Cham : Springer International Publishing, [2017]- |
مواضيع طبية MeSH: | Cerebral Small Vessel Diseases*/pathology , Cerebral Small Vessel Diseases*/etiology , Diet, High-Fat*/adverse effects , Rats, Inbred SHR* , Rats, Inbred WKY*, Animals ; Rats ; Male ; Blood-Brain Barrier/pathology ; Magnetic Resonance Imaging ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Claudin-5/metabolism ; Disease Models, Animal ; White Matter/pathology ; NADPH Oxidase 2/metabolism ; Hypertension/pathology |
مستخلص: | Cerebral small vessel diseases (CSVD) are neurological disorders associated with microvessels, manifested pathologically as white matter (WM) changes and cortical microbleeds, with hypertension as a risk factor. Additionally, a high-fat diet (HFD) can affect peripheral vessel health. Our study explored how HFD affects cerebral small vessels in normotensive WKY, hypertensive SHR, and SHR/SP rats. The MRI results revealed that HFD specifically increased WM hyperintensity in SHR/SP rats. Pathologically, it increased WM pallor and vacuolation in SHR and SHR/SP rats. Levels of blood-brain barrier (BBB) protein claudin 5 were decreased in SHR and SHR/SP compared to WKY, with HFD having minimal impact on these levels. Conversely, collagen IV levels remained consistent among the rat strains, which were increased by HFD. Consequently, HFD caused vessel leakage in all rat strains, particularly within the corpus callosum of SHR/SP rats. To understand the underlying mechanisms, we assessed the levels of hypoxia-inducible factor-1α (HIF-1α), Gp91-phox, and neuroinflammatory markers astrocytes, and microglia were increased in SHR and SHR/SP compared to WKY and were further elevated by HFD in all rat strains. Gp91-phox was also increased in SHR and SHR/SP compared to WKY, with HFD causing an increase in WKY but little effect in SHR and SHR/SP. In conclusion, our study demonstrates that HFD, in combined with hypertension, intensifies cerebral pathological alterations in CSVD rats. This exacerbation involves increased oxidative stress and HIF-1α in cerebral vessels, triggering neuroinflammation, vascular basement membrane remodeling, IgG leakage, and ultimately WM damage. (© 2024. The Author(s), under exclusive licence to American Aging Association.) |
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فهرسة مساهمة: | Keywords: Blood–brain barrier (BBB); Cerebral small vessel disease (CSVD); High-fat diet (HFD); SHR; SHR/SP; White matter (WM) |
المشرفين على المادة: | 0 (Hypoxia-Inducible Factor 1, alpha Subunit) 0 (Claudin-5) EC 1.6.3.- (NADPH Oxidase 2) 0 (Hif1a protein, rat) 0 (Cldn5 protein, rat) EC 1.6.3.- (Cybb protein, rat) |
تواريخ الأحداث: | Date Created: 20240206 Date Completed: 20240705 Latest Revision: 20240722 |
رمز التحديث: | 20240723 |
مُعرف محوري في PubMed: | PMC11226591 |
DOI: | 10.1007/s11357-024-01074-7 |
PMID: | 38319539 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2509-2723 |
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DOI: | 10.1007/s11357-024-01074-7 |