دورية أكاديمية
أعرض في EDS

Effect of high-fat diet on cerebral pathological changes of cerebral small vessel disease in SHR/SP rats.

التفاصيل البيبلوغرافية
العنوان: Effect of high-fat diet on cerebral pathological changes of cerebral small vessel disease in SHR/SP rats.
المؤلفون: Zhang Y; Department of Neurology, Faculty of Medicine, Shimane University, 89-1 Enya-Cho, Izumo, 693-8501, Japan.; Department of Pharmacology, School of Basic Medical Sciences, Heilongjiang University of Chinese Medicine, Harbin, 150040, China., Sheikh AM; Department of Laboratory Medicine, Faculty of Medicine, Shimane University, Izumo, 693-8501, Japan., Tabassum S; Department of Laboratory Medicine, Faculty of Medicine, Shimane University, Izumo, 693-8501, Japan., Iwasa K; Department of Neurology, Faculty of Medicine, Shimane University, 89-1 Enya-Cho, Izumo, 693-8501, Japan., Shibly AZ; Department of Neurology, Faculty of Medicine, Shimane University, 89-1 Enya-Cho, Izumo, 693-8501, Japan.; Department of Biotechnology and Genetic Engineering, Mawlana Bhashani Science and Technology University, Santosh, Tangail, 1902, Bangladesh., Zhou X; Department of Neurology, Faculty of Medicine, Shimane University, 89-1 Enya-Cho, Izumo, 693-8501, Japan.; Department of Neurology, Zhoushan Hospital, Zhoushan, 316004, China., Wang R; Department of Neurology, Faculty of Medicine, Shimane University, 89-1 Enya-Cho, Izumo, 693-8501, Japan., Bhuiya J; Department of Neurology, Faculty of Medicine, Shimane University, 89-1 Enya-Cho, Izumo, 693-8501, Japan., Abdullah FB; Department of Neurology, Faculty of Medicine, Shimane University, 89-1 Enya-Cho, Izumo, 693-8501, Japan., Yano S; Department of Laboratory Medicine, Faculty of Medicine, Shimane University, Izumo, 693-8501, Japan., Aoki Y; Department of Neurology, Faculty of Medicine, Shimane University, 89-1 Enya-Cho, Izumo, 693-8501, Japan., Nagai A; Department of Neurology, Faculty of Medicine, Shimane University, 89-1 Enya-Cho, Izumo, 693-8501, Japan. anagai@med.shimane-u.ac.jp.
المصدر: GeroScience [Geroscience] 2024 Aug; Vol. 46 (4), pp. 3779-3800. Date of Electronic Publication: 2024 Feb 06.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer International Publishing Country of Publication: Switzerland NLM ID: 101686284 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2509-2723 (Electronic) Linking ISSN: 25092723 NLM ISO Abbreviation: Geroscience Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Cham : Springer International Publishing, [2017]-
مواضيع طبية MeSH: Cerebral Small Vessel Diseases*/pathology , Cerebral Small Vessel Diseases*/etiology , Diet, High-Fat*/adverse effects , Rats, Inbred SHR* , Rats, Inbred WKY*, Animals ; Rats ; Male ; Blood-Brain Barrier/pathology ; Magnetic Resonance Imaging ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Claudin-5/metabolism ; Disease Models, Animal ; White Matter/pathology ; NADPH Oxidase 2/metabolism ; Hypertension/pathology
مستخلص: Cerebral small vessel diseases (CSVD) are neurological disorders associated with microvessels, manifested pathologically as white matter (WM) changes and cortical microbleeds, with hypertension as a risk factor. Additionally, a high-fat diet (HFD) can affect peripheral vessel health. Our study explored how HFD affects cerebral small vessels in normotensive WKY, hypertensive SHR, and SHR/SP rats. The MRI results revealed that HFD specifically increased WM hyperintensity in SHR/SP rats. Pathologically, it increased WM pallor and vacuolation in SHR and SHR/SP rats. Levels of blood-brain barrier (BBB) protein claudin 5 were decreased in SHR and SHR/SP compared to WKY, with HFD having minimal impact on these levels. Conversely, collagen IV levels remained consistent among the rat strains, which were increased by HFD. Consequently, HFD caused vessel leakage in all rat strains, particularly within the corpus callosum of SHR/SP rats. To understand the underlying mechanisms, we assessed the levels of hypoxia-inducible factor-1α (HIF-1α), Gp91-phox, and neuroinflammatory markers astrocytes, and microglia were increased in SHR and SHR/SP compared to WKY and were further elevated by HFD in all rat strains. Gp91-phox was also increased in SHR and SHR/SP compared to WKY, with HFD causing an increase in WKY but little effect in SHR and SHR/SP. In conclusion, our study demonstrates that HFD, in combined with hypertension, intensifies cerebral pathological alterations in CSVD rats. This exacerbation involves increased oxidative stress and HIF-1α in cerebral vessels, triggering neuroinflammation, vascular basement membrane remodeling, IgG leakage, and ultimately WM damage.
(© 2024. The Author(s), under exclusive licence to American Aging Association.)
References: Biomedicines. 2022 Dec 25;11(1):. (PMID: 36672558)
Free Radic Biol Med. 2010 Jul 1;49(1):22-30. (PMID: 20347034)
J Neuroinflammation. 2021 Aug 10;18(1):175. (PMID: 34376193)
J Biol Chem. 2013 Apr 12;288(15):10819-29. (PMID: 23423382)
Nutrients. 2023 Jun 14;15(12):. (PMID: 37375654)
Kidney Int. 2002 Sep;62(3):901-13. (PMID: 12164872)
Neurology. 2017 Nov 21;89(21):2143-2150. (PMID: 29070665)
J Am Coll Cardiol. 2020 May 5;75(17):2189-2203. (PMID: 32354385)
Neurosci Biobehav Rev. 2018 Jul;90:164-173. (PMID: 29656031)
Jikken Dobutsu. 1991 Jul;40(3):331-6. (PMID: 1915600)
Medicine (Baltimore). 2021 Dec 23;100(51):e28229. (PMID: 34941088)
Brain Sci. 2021 Dec 02;11(12):. (PMID: 34942905)
Proc Natl Acad Sci U S A. 2009 Feb 10;106(6):1977-82. (PMID: 19174516)
J Stroke. 2018 Sep;20(3):302-320. (PMID: 30309226)
Stroke. 2020 Jan;51(1):12-20. (PMID: 31752611)
PLoS One. 2017 Feb 23;12(2):e0172645. (PMID: 28231304)
Mol Med Rep. 2015 Nov;12(5):7211-20. (PMID: 26459855)
J Cereb Blood Flow Metab. 2016 Jan;36(1):264-74. (PMID: 25899292)
Am J Hypertens. 2018 Sep 11;31(10):1067-1078. (PMID: 29788246)
Mol Neurodegener. 2023 Jul 11;18(1):46. (PMID: 37434208)
PLoS One. 2016 Mar 04;11(3):e0150657. (PMID: 26942763)
Sci Rep. 2021 Nov 30;11(1):23149. (PMID: 34848820)
Open Med (Wars). 2020 Nov 27;16(1):23. (PMID: 33364430)
Front Physiol. 2019 Oct 24;10:1317. (PMID: 31708793)
Front Cardiovasc Med. 2021 Feb 24;8:632131. (PMID: 33718454)
Circ Res. 1982 Oct;51(4):494-503. (PMID: 7127684)
J Hum Hypertens. 2023 Aug;37(8):619-625. (PMID: 36335169)
Adv Chronic Kidney Dis. 2019 Mar;26(2):122-130. (PMID: 31023446)
Curr Neurovasc Res. 2016;13(1):58-67. (PMID: 26503025)
J Neurochem. 2008 Jan;104(1):147-54. (PMID: 17971126)
J Neuropathol Exp Neurol. 2012 Dec;71(12):1113-22. (PMID: 23147507)
PLoS One. 2017 Aug 3;12(8):e0181500. (PMID: 28771483)
Jpn Heart J. 1976 May;17(3):404-6. (PMID: 948136)
Front Neurol. 2022 Apr 11;13:861714. (PMID: 35481273)
Curr Neurovasc Res. 2009 Nov;6(4):279-87. (PMID: 19807651)
J Clin Hypertens (Greenwich). 2020 Nov;22(11):1968-1973. (PMID: 33459521)
Diabetes. 2010 Jan;59(1):228-35. (PMID: 19808897)
Oxid Med Cell Longev. 2021 Oct 19;2021:6114132. (PMID: 34712385)
Cell Biol Int. 2016 Nov;40(11):1187-1194. (PMID: 27542820)
Behav Brain Res. 2018 Feb 26;339:39-46. (PMID: 28887194)
Theranostics. 2022 Jan 16;12(4):1639-1658. (PMID: 35198062)
Adv Clin Exp Med. 2021 Mar;30(3):349-356. (PMID: 33768739)
Magn Reson Med. 2001 May;45(5):791-800. (PMID: 11323805)
J Cereb Blood Flow Metab. 2019 Jul;39(7):1232-1246. (PMID: 29350576)
J Cereb Blood Flow Metab. 2012 Jan;32(1):81-92. (PMID: 21792241)
Cell Transplant. 2018 Dec;27(12):1711-1722. (PMID: 30251566)
Front Endocrinol (Lausanne). 2022 Jan 11;12:805637. (PMID: 35087478)
Stroke. 2015 Nov;46(11):3131-6. (PMID: 26451022)
J Clin Invest. 2004 Dec;114(12):1752-61. (PMID: 15599400)
Stroke. 2016 Feb;47(2):554-60. (PMID: 26742799)
PLoS One. 2013;8(2):e56264. (PMID: 23441170)
فهرسة مساهمة: Keywords: Blood–brain barrier (BBB); Cerebral small vessel disease (CSVD); High-fat diet (HFD); SHR; SHR/SP; White matter (WM)
المشرفين على المادة: 0 (Hypoxia-Inducible Factor 1, alpha Subunit)
0 (Claudin-5)
EC 1.6.3.- (NADPH Oxidase 2)
0 (Hif1a protein, rat)
0 (Cldn5 protein, rat)
EC 1.6.3.- (Cybb protein, rat)
تواريخ الأحداث: Date Created: 20240206 Date Completed: 20240705 Latest Revision: 20240722
رمز التحديث: 20240723
مُعرف محوري في PubMed: PMC11226591
DOI: 10.1007/s11357-024-01074-7
PMID: 38319539
قاعدة البيانات: MEDLINE
الوصف
تدمد:2509-2723
DOI:10.1007/s11357-024-01074-7