Editorial & Opinion
An Interleukin-15 Superagonist with BCG - A Major Therapeutic Advancement or Just a Small Step in the Right Direction?
العنوان: | An Interleukin-15 Superagonist with BCG - A Major Therapeutic Advancement or Just a Small Step in the Right Direction? |
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المؤلفون: | Pietzak EJ; Urologic Oncology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York., Herr HW; Urologic Oncology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York. |
المصدر: | NEJM evidence [NEJM Evid] 2023 Jan; Vol. 2 (1), pp. EVIDe2200264. Date of Electronic Publication: 2022 Dec 27. |
نوع المنشور: | Editorial |
اللغة: | English |
بيانات الدورية: | Publisher: NEJM Group, a division of the Massachusetts Medical Society Country of Publication: United States NLM ID: 9918317485806676 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2766-5526 (Electronic) Linking ISSN: 27665526 NLM ISO Abbreviation: NEJM Evid Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: [Waltham, MA] : NEJM Group, a division of the Massachusetts Medical Society, [2022]- |
مواضيع طبية MeSH: | Non-Muscle Invasive Bladder Neoplasms* , Urinary Bladder Neoplasms*/drug therapy, Humans ; BCG Vaccine/therapeutic use ; Adjuvants, Immunologic/therapeutic use ; Interleukin-15/therapeutic use ; Neoplasm Recurrence, Local/drug therapy |
مستخلص: | For more than 40 years, intravesical Bacillus Calmette-Guérin (BCG) has remained the most effective treatment for non-muscle-invasive bladder cancer (NMIBC); however, tumor recurrence and progression are common, especially for those patients with carcinoma in situ (CIS). 1 Therapeutic options are limited when treatment with BCG fails, and radical cystectomy remains the only curative treatment. BCG-unresponsive NMIBC criteria were developed in 2015 to identify patients for whom additional BCG would likely not be effective and to facilitate clinical trials of novel therapies. 2,3 . |
المشرفين على المادة: | 0 (BCG Vaccine) 0 (Adjuvants, Immunologic) 0 (Interleukin-15) |
تواريخ الأحداث: | Date Created: 20240206 Date Completed: 20240208 Latest Revision: 20240208 |
رمز التحديث: | 20240208 |
DOI: | 10.1056/EVIDe2200264 |
PMID: | 38320108 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2766-5526 |
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DOI: | 10.1056/EVIDe2200264 |