An Interleukin-15 Superagonist with BCG - A Major Therapeutic Advancement or Just a Small Step in the Right Direction?

التفاصيل البيبلوغرافية
العنوان:	An Interleukin-15 Superagonist with BCG - A Major Therapeutic Advancement or Just a Small Step in the Right Direction?
المؤلفون:	Pietzak EJ; Urologic Oncology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York., Herr HW; Urologic Oncology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York.
المصدر:	NEJM evidence [NEJM Evid] 2023 Jan; Vol. 2 (1), pp. EVIDe2200264. Date of Electronic Publication: 2022 Dec 27.
نوع المنشور:	Editorial
اللغة:	English
بيانات الدورية:	Publisher: NEJM Group, a division of the Massachusetts Medical Society Country of Publication: United States NLM ID: 9918317485806676 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2766-5526 (Electronic) Linking ISSN: 27665526 NLM ISO Abbreviation: NEJM Evid Subsets: MEDLINE
أسماء مطبوعة:	Original Publication: [Waltham, MA] : NEJM Group, a division of the Massachusetts Medical Society, [2022]-
مواضيع طبية MeSH:	Non-Muscle Invasive Bladder Neoplasms* , Urinary Bladder Neoplasms*/drug therapy, Humans ; BCG Vaccine/therapeutic use ; Adjuvants, Immunologic/therapeutic use ; Interleukin-15/therapeutic use ; Neoplasm Recurrence, Local/drug therapy
مستخلص:	For more than 40 years, intravesical Bacillus Calmette-Guérin (BCG) has remained the most effective treatment for non-muscle-invasive bladder cancer (NMIBC); however, tumor recurrence and progression are common, especially for those patients with carcinoma in situ (CIS). ¹ Therapeutic options are limited when treatment with BCG fails, and radical cystectomy remains the only curative treatment. BCG-unresponsive NMIBC criteria were developed in 2015 to identify patients for whom additional BCG would likely not be effective and to facilitate clinical trials of novel therapies. ^2,3 .
المشرفين على المادة:	0 (BCG Vaccine) 0 (Adjuvants, Immunologic) 0 (Interleukin-15)
تواريخ الأحداث:	Date Created: 20240206 Date Completed: 20240208 Latest Revision: 20240208
رمز التحديث:	20240208
DOI:	10.1056/EVIDe2200264
PMID:	38320108
قاعدة البيانات:	MEDLINE

الوصف
تدمد:	2766-5526
DOI:	10.1056/EVIDe2200264