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Explaining the Unexplained: Examining the Predictive Value of Semen Parameters, Sperm DNA Fragmentation and Metal Levels in Unexplained Infertility.

التفاصيل البيبلوغرافية
العنوان: Explaining the Unexplained: Examining the Predictive Value of Semen Parameters, Sperm DNA Fragmentation and Metal Levels in Unexplained Infertility.
المؤلفون: Ghuman NK; Department of Obstetrics and Gynaecology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India., Shukla KK; Department of Trauma and Emergency, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India., Nandagopal S; Department of Biochemistry, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India., Raikar S; Department of Obstetrics and Gynaecology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India., Kumar S; Department of Biochemistry, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India., Kathuria P; Department of Obstetrics and Gynaecology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India., Choudhary D; Department of Obstetrics and Gynaecology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India., Elhence P; Department of Pathology and Lab Medicine, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India., Singh P; Department of Obstetrics and Gynaecology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.
المصدر: Journal of human reproductive sciences [J Hum Reprod Sci] 2023 Oct-Dec; Vol. 16 (4), pp. 317-323. Date of Electronic Publication: 2023 Dec 29.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Medknow Publications Country of Publication: India NLM ID: 101473512 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0974-1208 (Print) Linking ISSN: 19984766 NLM ISO Abbreviation: J Hum Reprod Sci Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Mumbai : Medknow Publications, 2008-
مستخلص: Background: There is ongoing research to find an optimum modality to predict male fertility potential.
Aims: To compare the semen parameters, sperm DNA damage and seminal metal levels of Zinc, Lead and Aluminium among the male partners of couples with unexplained infertility and men with proven fertility.
Settings and Design: Prospective case-control study at a tertiary level teaching hospital.
Materials and Methods: One hundred male partners of couples with unexplained subfertility and 50 men with proven fertility were included in the study. Male partners of unexplained infertility couples and fertile men were compared for their semen parameters, sperm DNA Fragmentation Index (DFI) and seminal metal levels in semen.
Statistical Analysis Used: Chi-square test, Student's t -test, sensitivity and specificity analysis, binomial logistic regression analysis.
Results: Fertile men had statistically significantly higher mean progressive sperm motility than male partners of unexplained infertility (53.12 ± 9.89% vs. 44.81 ± 19.47%, P = 0.005). Semen volume and sperm concentration were comparable among the cases and control population. The mean sperm DFI was significantly lower among fertile men (10.83 ± 6.28 vs. 21.38 ± 10.28, P < 0.0001). Plotting the receiver-operating characteristic curve the threshold for discrimination was calculated to be 18% DFI. The sensitivity specificity and overall accuracy were 43%, 84% and 56.67%, respectively when the DFI cut-off was set at 18%. Zinc concentration in the semen had a strong positive correlation (Point Biserial correlation coefficient = 0.831) with fertility, whereas lead and aluminium had a moderate negative correlation.
Conclusion: Conventional semen analysis had limited differentiating ability for unexplained infertility. The sperm DFI may be employed for explanatory purposes among couples with unexplained subfertility. A lower discriminatory threshold of DFI (18%) has better overall accuracy as opposed to a 30% cutpoint for unexplained subfertility. Among metals, Zinc was strongly correlated with fertility status.
Competing Interests: There are no conflicts of interest.
(Copyright: © 2023 Journal of Human Reproductive Sciences.)
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فهرسة مساهمة: Keywords: Metal concentration; semen parameters; sperm DNA fragmentation; unexplained infertility
تواريخ الأحداث: Date Created: 20240207 Latest Revision: 20240210
رمز التحديث: 20240210
مُعرف محوري في PubMed: PMC10841936
DOI: 10.4103/jhrs.jhrs_140_23
PMID: 38322633
قاعدة البيانات: MEDLINE
الوصف
تدمد:0974-1208
DOI:10.4103/jhrs.jhrs_140_23