دورية أكاديمية
أعرض في EDS

Randomized Controlled Trials of Pulmonary Vasodilator Therapy Adjunctive to Inhaled Nitric Oxide for Persistent Pulmonary Hypertension of the Newborn: A Systematic Review.

التفاصيل البيبلوغرافية
العنوان: Randomized Controlled Trials of Pulmonary Vasodilator Therapy Adjunctive to Inhaled Nitric Oxide for Persistent Pulmonary Hypertension of the Newborn: A Systematic Review.
المؤلفون: Coletti K; Department of Pediatrics, Division of Neonatology, The Children's Hospital of Philadelphia, 3401 Civic Center Boulevard, Philadelphia, PA 19104, USA. Electronic address: colettik@chop.edu., Wild KT; Department of Pediatrics, Division of Neonatology, The Children's Hospital of Philadelphia, 3401 Civic Center Boulevard, Philadelphia, PA 19104, USA; Perelman School of Medicine, University of Pennsylvania, 8th Floor Ravdin Building, 3400 Spruce Street, Philadelphia, PA 19104, USA., Foglia EE; Department of Pediatrics, Division of Neonatology, The Children's Hospital of Philadelphia, 3401 Civic Center Boulevard, Philadelphia, PA 19104, USA; Perelman School of Medicine, University of Pennsylvania, 8th Floor Ravdin Building, 3400 Spruce Street, Philadelphia, PA 19104, USA., Otter SC; Department of Neonatal and Pediatric Intensive Care, Division of Pediatric Intensive Care, Erasmus MC University Medical Center, Wytemaweg 80, Rotterdam 3015CN, The Netherlands., Kirpalani H; Emeritus, Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA; Emeritus, Pediatrics, McMaster University, 1200 Main Street West, Hamilton, Ontario L8N3Z5, Canada.
المصدر: Clinics in perinatology [Clin Perinatol] 2024 Mar; Vol. 51 (1), pp. 253-269. Date of Electronic Publication: 2023 Dec 28.
نوع المنشور: Systematic Review; Journal Article; Review; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier Health Sciences Division Country of Publication: United States NLM ID: 7501306 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-9840 (Electronic) Linking ISSN: 00955108 NLM ISO Abbreviation: Clin Perinatol Subsets: MEDLINE
أسماء مطبوعة: Publication: <2005->: Philadelphia : Elsevier Health Sciences Division
Original Publication: Philadelphia, Saunders.
مواضيع طبية MeSH: Nitric Oxide*/therapeutic use , Hypertension, Pulmonary*/drug therapy, Infant, Newborn ; Humans ; Vasodilator Agents/therapeutic use ; Bayes Theorem ; Randomized Controlled Trials as Topic ; Administration, Inhalation
مستخلص: Inhaled nitric oxide (iNO) is a pulmonary vasodilator considered standard of care to treat persistent pulmonary hypertension of the newborn. However, not all infants respond to iNO. The authors performed a systematic review to examine methodology, outcomes, and challenges of randomized controlled trials testing pulmonary vasodilator medications adjunctive to iNO. The 5 trials identified showed heterogeneity in eligibility criteria and outcomes assessed. No trial achieved recruitment goals, limiting conclusions regarding efficacy, safety, and pharmacology. Trial design consensus and alternative methodologic strategies such as deferred consent, real-world controls, nonrandomized database assessments, and Bayesian statistical approaches are needed.
Competing Interests: Disclosure The authors have nothing to disclose.
(Copyright © 2023 Elsevier Inc. All rights reserved.)
فهرسة مساهمة: Keywords: Inhaled nitric oxide; Persistent pulmonary hypertension of the newborn; Pulmonary vasodilator; Randomized controlled trial; Term and late-preterm infants
المشرفين على المادة: 31C4KY9ESH (Nitric Oxide)
0 (Vasodilator Agents)
تواريخ الأحداث: Date Created: 20240207 Date Completed: 20240209 Latest Revision: 20240416
رمز التحديث: 20240416
DOI: 10.1016/j.clp.2023.11.009
PMID: 38325945
قاعدة البيانات: MEDLINE
الوصف
تدمد:1557-9840
DOI:10.1016/j.clp.2023.11.009