دورية أكاديمية
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Identification of direct connections between the dura and the brain.

التفاصيل البيبلوغرافية
العنوان: Identification of direct connections between the dura and the brain.
المؤلفون: Smyth LCD; Brain Immunology and Glia (BIG) Center, Washington University in St Louis, St Louis, MO, USA. l.c.smyth@wustl.edu.; Department of Pathology and Immunology, School of Medicine, Washington University in St Louis, St Louis, MO, USA. l.c.smyth@wustl.edu., Xu D; Brain Immunology and Glia (BIG) Center, Washington University in St Louis, St Louis, MO, USA.; Department of Pathology and Immunology, School of Medicine, Washington University in St Louis, St Louis, MO, USA., Okar SV; Translational Neuroradiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Dykstra T; Brain Immunology and Glia (BIG) Center, Washington University in St Louis, St Louis, MO, USA.; Department of Pathology and Immunology, School of Medicine, Washington University in St Louis, St Louis, MO, USA., Rustenhoven J; Brain Immunology and Glia (BIG) Center, Washington University in St Louis, St Louis, MO, USA.; Department of Pathology and Immunology, School of Medicine, Washington University in St Louis, St Louis, MO, USA.; Department of Pharmacology and Clinical Pharmacology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.; Centre for Brain Research, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand., Papadopoulos Z; Brain Immunology and Glia (BIG) Center, Washington University in St Louis, St Louis, MO, USA.; Department of Pathology and Immunology, School of Medicine, Washington University in St Louis, St Louis, MO, USA.; Neuroscience Graduate Program, School of Medicine, Washington University in St Louis, St Louis, MO, USA., Bhasiin K; Brain Immunology and Glia (BIG) Center, Washington University in St Louis, St Louis, MO, USA.; Department of Pathology and Immunology, School of Medicine, Washington University in St Louis, St Louis, MO, USA., Kim MW; Brain Immunology and Glia (BIG) Center, Washington University in St Louis, St Louis, MO, USA.; Department of Pathology and Immunology, School of Medicine, Washington University in St Louis, St Louis, MO, USA.; Immunology Graduate Program, School of Medicine, Washington University in St Louis, St Louis, MO, USA., Drieu A; Brain Immunology and Glia (BIG) Center, Washington University in St Louis, St Louis, MO, USA.; Department of Pathology and Immunology, School of Medicine, Washington University in St Louis, St Louis, MO, USA., Mamuladze T; Brain Immunology and Glia (BIG) Center, Washington University in St Louis, St Louis, MO, USA.; Department of Pathology and Immunology, School of Medicine, Washington University in St Louis, St Louis, MO, USA.; Immunology Graduate Program, School of Medicine, Washington University in St Louis, St Louis, MO, USA., Blackburn S; Brain Immunology and Glia (BIG) Center, Washington University in St Louis, St Louis, MO, USA.; Department of Pathology and Immunology, School of Medicine, Washington University in St Louis, St Louis, MO, USA., Gu X; Brain Immunology and Glia (BIG) Center, Washington University in St Louis, St Louis, MO, USA.; Department of Pathology and Immunology, School of Medicine, Washington University in St Louis, St Louis, MO, USA., Gaitán MI; Translational Neuroradiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Nair G; Quantitative MRI Core Facility, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Storck SE; Brain Immunology and Glia (BIG) Center, Washington University in St Louis, St Louis, MO, USA.; Department of Pathology and Immunology, School of Medicine, Washington University in St Louis, St Louis, MO, USA., Du S; Brain Immunology and Glia (BIG) Center, Washington University in St Louis, St Louis, MO, USA.; Department of Pathology and Immunology, School of Medicine, Washington University in St Louis, St Louis, MO, USA.; Immunology Graduate Program, School of Medicine, Washington University in St Louis, St Louis, MO, USA., White MA; Department of Genetics, Washington University School of Medicine, Washington University in St Louis, St Louis, MO, USA., Bayguinov P; Washington University Center for Cellular Imaging, Washington University School of Medicine, Washington University in St Louis, St Louis, MO, USA.; Department of Neuroscience, Washington University School of Medicine, Washington University in St Louis, St Louis, MO, USA., Smirnov I; Brain Immunology and Glia (BIG) Center, Washington University in St Louis, St Louis, MO, USA.; Department of Pathology and Immunology, School of Medicine, Washington University in St Louis, St Louis, MO, USA., Dikranian K; Department of Neuroscience, Washington University School of Medicine, Washington University in St Louis, St Louis, MO, USA., Reich DS; Translational Neuroradiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Kipnis J; Brain Immunology and Glia (BIG) Center, Washington University in St Louis, St Louis, MO, USA. kipnis@wustl.edu.; Department of Pathology and Immunology, School of Medicine, Washington University in St Louis, St Louis, MO, USA. kipnis@wustl.edu.; Neuroscience Graduate Program, School of Medicine, Washington University in St Louis, St Louis, MO, USA. kipnis@wustl.edu.; Immunology Graduate Program, School of Medicine, Washington University in St Louis, St Louis, MO, USA. kipnis@wustl.edu.
المصدر: Nature [Nature] 2024 Mar; Vol. 627 (8002), pp. 165-173. Date of Electronic Publication: 2024 Feb 07.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
أسماء مطبوعة: Publication: Basingstoke : Nature Publishing Group
Original Publication: London, Macmillan Journals ltd.
مواضيع طبية MeSH: Arachnoid*/anatomy & histology , Arachnoid*/blood supply , Arachnoid*/immunology , Arachnoid*/metabolism , Brain*/anatomy & histology , Brain*/blood supply , Brain*/immunology , Brain*/metabolism , Dura Mater*/anatomy & histology , Dura Mater*/blood supply , Dura Mater*/immunology , Dura Mater*/metabolism, Animals ; Humans ; Mice ; Biological Transport ; Encephalomyelitis, Autoimmune, Experimental/immunology ; Encephalomyelitis, Autoimmune, Experimental/metabolism ; Gene Expression Profiling ; Magnetic Resonance Imaging ; Mice, Transgenic ; Subarachnoid Space/anatomy & histology ; Subarachnoid Space/blood supply ; Subarachnoid Space/immunology ; Subarachnoid Space/metabolism ; Cerebrospinal Fluid/metabolism ; Veins/metabolism
مستخلص: The arachnoid barrier delineates the border between the central nervous system and dura mater. Although the arachnoid barrier creates a partition, communication between the central nervous system and the dura mater is crucial for waste clearance and immune surveillance 1,2 . How the arachnoid barrier balances separation and communication is poorly understood. Here, using transcriptomic data, we developed transgenic mice to examine specific anatomical structures that function as routes across the arachnoid barrier. Bridging veins create discontinuities where they cross the arachnoid barrier, forming structures that we termed arachnoid cuff exit (ACE) points. The openings that ACE points create allow the exchange of fluids and molecules between the subarachnoid space and the dura, enabling the drainage of cerebrospinal fluid and limited entry of molecules from the dura to the subarachnoid space. In healthy human volunteers, magnetic resonance imaging tracers transit along bridging veins in a similar manner to access the subarachnoid space. Notably, in neuroinflammatory conditions such as experimental autoimmune encephalomyelitis, ACE points also enable cellular trafficking, representing a route for immune cells to directly enter the subarachnoid space from the dura mater. Collectively, our results indicate that ACE points are a critical part of the anatomy of neuroimmune communication in both mice and humans that link the central nervous system with the dura and its immunological diversity and waste clearance systems.
(© 2024. The Author(s), under exclusive licence to Springer Nature Limited.)
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معلومات مُعتمدة: P01 AG078106 United States AG NIA NIH HHS; R01 AG034113 United States AG NIA NIH HHS; R37 AG034113 United States AG NIA NIH HHS; ZIA NS003119 United States ImNIH Intramural NIH HHS
تواريخ الأحداث: Date Created: 20240207 Date Completed: 20240308 Latest Revision: 20240723
رمز التحديث: 20240725
مُعرف محوري في PubMed: PMC11254388
DOI: 10.1038/s41586-023-06993-7
PMID: 38326613
قاعدة البيانات: MEDLINE
الوصف
تدمد:1476-4687
DOI:10.1038/s41586-023-06993-7