دورية أكاديمية
Acute kidney injury in neonates with hypoxic ischemic encephalopathy based on serum creatinine decline compared to KDIGO criteria.
| العنوان: | Acute kidney injury in neonates with hypoxic ischemic encephalopathy based on serum creatinine decline compared to KDIGO criteria. |
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| المؤلفون: | Ahn HC; Division of Pediatric Nephrology, Stanford University School of Medicine, Palo Alto, CA, USA. haejun.ahn@swedish.org.; Pediatric Nephrology, Swedish Health, Seattle, WA, USA. haejun.ahn@swedish.org., Frymoyer A; Division of Neonatal and Developmental Medicine, Stanford University School of Medicine, Palo Alto, CA, USA., Boothroyd DB; Quantitative Sciences Unit, Stanford University School of Medicine, Palo Alto, CA, USA., Bonifacio S; Division of Neonatal and Developmental Medicine, Stanford University School of Medicine, Palo Alto, CA, USA., Sutherland SM; Division of Pediatric Nephrology, Stanford University School of Medicine, Palo Alto, CA, USA., Chock VY; Division of Neonatal and Developmental Medicine, Stanford University School of Medicine, Palo Alto, CA, USA. |
| المصدر: | Pediatric nephrology (Berlin, Germany) [Pediatr Nephrol] 2024 Sep; Vol. 39 (9), pp. 2789-2796. Date of Electronic Publication: 2024 Feb 07. |
| نوع المنشور: | Journal Article; Comparative Study |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer International Country of Publication: Germany NLM ID: 8708728 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-198X (Electronic) Linking ISSN: 0931041X NLM ISO Abbreviation: Pediatr Nephrol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Berlin : Springer International Original Publication: Berlin : Springer International, c1987- |
| مواضيع طبية MeSH: | Acute Kidney Injury*/blood , Acute Kidney Injury*/etiology , Acute Kidney Injury*/diagnosis , Acute Kidney Injury*/mortality , Acute Kidney Injury*/therapy , Hypoxia-Ischemia, Brain*/diagnosis , Hypoxia-Ischemia, Brain*/blood , Hypoxia-Ischemia, Brain*/therapy , Hypoxia-Ischemia, Brain*/complications , Hypoxia-Ischemia, Brain*/mortality , Creatinine*/blood, Humans ; Infant, Newborn ; Retrospective Studies ; Female ; Male ; Hypothermia, Induced ; Severity of Illness Index ; Magnetic Resonance Imaging ; Length of Stay/statistics & numerical data |
| مستخلص: | Background: Neonates with hypoxic ischemic encephalopathy receiving therapeutic hypothermia (HIE + TH) are at risk for acute kidney injury (AKI). The standardized Kidney Disease Improving Global Outcomes (KDIGO) criteria identifies AKI based on a rise in serum creatinine (SCr) or reduced urine output. This definition is challenging to apply in neonates given the physiologic decline in SCr during the first week of life. Gupta et al. proposed alternative neonatal criteria centered on rate of SCr decline. This study aimed to compare the rate of AKI based on KDIGO and Gupta in neonates with HIE and to examine associations with mortality and morbidity. Methods: A retrospective review was performed of neonates with moderate to severe HIE + TH from 2008 to 2020 at a single center. AKI was assessed in the first 7 days after birth by KDIGO and Gupta criteria. Mortality, brain MRI severity of injury, length of stay, and duration of respiratory support were compared between AKI groups. Results: Among 225 neonates, 64 (28%) met KDIGO, 69 (31%) neonates met Gupta but not KDIGO, and 92 (41%) did not meet either definition. Both KDIGO-AKI and GuptaOnly-AKI groups had an increased risk of the composite mortality and/or moderate/severe brain MRI injury along with longer length of stay and prolonged duration of respiratory support compared to those without AKI. Conclusions: AKI in neonates with HIE + TH was common and varied by definition. The Gupta definition based on rate of SCr decline identified additional neonates not captured by KDIGO criteria who are at increased risk for adverse outcomes. Incorporating the rate of SCr decline into the neonatal AKI definition may increase identification of clinically relevant kidney injury in neonates with HIE + TH. (© 2024. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.) |
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| فهرسة مساهمة: | Keywords: Acute kidney injury; Hypoxic ischemic encephalopathy; KDIGO; Neonatal; Neonatal asphyxia |
| المشرفين على المادة: | AYI8EX34EU (Creatinine) |
| تواريخ الأحداث: | Date Created: 20240207 Date Completed: 20240725 Latest Revision: 20240725 |
| رمز التحديث: | 20240726 |
| DOI: | 10.1007/s00467-024-06287-8 |
| PMID: | 38326648 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1432-198X |
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| DOI: | 10.1007/s00467-024-06287-8 |