دورية أكاديمية
Prebiotic proanthocyanidins inhibit bile reflux-induced esophageal adenocarcinoma through reshaping the gut microbiome and esophageal metabolome.
| العنوان: | Prebiotic proanthocyanidins inhibit bile reflux-induced esophageal adenocarcinoma through reshaping the gut microbiome and esophageal metabolome. |
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| المؤلفون: | Weh KM; Department of Surgery, Section of Thoracic Surgery, and.; Rogel Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan, USA., Howard CL; Department of Surgery, Section of Thoracic Surgery, and.; Rogel Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan, USA., Zhang Y; Department of Surgery, Section of Thoracic Surgery, and.; Rogel Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan, USA., Tripp BA; Department of Electrical and Computer Engineering, and., Clarke JL; Department of Statistics, Department of Food Science Technology, Quantitative Life Sciences Initiative, University of Nebraska-Lincoln, Lincoln, Nebraska, USA., Howell AB; Marucci Center for Blueberry and Cranberry Research, Rutgers University, Chatsworth, New Jersey, USA., Rubenstein JH; Division of Gastroenterology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.; LTC Charles S. Kettles Veterans Affairs Medical Center, Ann Arbor, Michigan, USA., Abrams JA; Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA., Westerhoff M; Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA., Kresty LA; Department of Surgery, Section of Thoracic Surgery, and.; Rogel Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan, USA. |
| المصدر: | JCI insight [JCI Insight] 2024 Feb 08; Vol. 9 (6). Date of Electronic Publication: 2024 Feb 08. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 101676073 Publication Model: Electronic Cited Medium: Internet ISSN: 2379-3708 (Electronic) Linking ISSN: 23793708 NLM ISO Abbreviation: JCI Insight Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Ann Arbor, Michigan : American Society for Clinical Investigation, [2016]- |
| مواضيع طبية MeSH: | Proanthocyanidins*/pharmacology , Proanthocyanidins*/therapeutic use , Proanthocyanidins*/metabolism , Gastrointestinal Microbiome*/physiology , Bile Reflux* , Adenocarcinoma*/genetics , Gastroesophageal Reflux*/drug therapy , Gastroesophageal Reflux*/genetics , Esophageal Neoplasms*, Humans ; Rats ; Animals ; Dysbiosis/drug therapy ; Rats, Sprague-Dawley ; Inflammation/drug therapy ; Metabolome |
| مستخلص: | The gut and local esophageal microbiome progressively shift from healthy commensal bacteria to inflammation-linked pathogenic bacteria in patients with gastroesophageal reflux disease, Barrett's esophagus, and esophageal adenocarcinoma (EAC). However, mechanisms by which microbial communities and metabolites contribute to reflux-driven EAC remain incompletely understood and challenging to target. Herein, we utilized a rat reflux-induced EAC model to investigate targeting the gut microbiome-esophageal metabolome axis with cranberry proanthocyanidins (C-PAC) to inhibit EAC progression. Sprague-Dawley rats, with or without reflux induction, received water or C-PAC ad libitum (700 μg/rat/day) for 25 or 40 weeks. C-PAC exerted prebiotic activity abrogating reflux-induced dysbiosis and mitigating bile acid metabolism and transport, culminating in significant inhibition of EAC through TLR/NF-κB/TP53 signaling cascades. At the species level, C-PAC mitigated reflux-induced pathogenic bacteria (Streptococcus parasanguinis, Escherichia coli, and Proteus mirabilis). C-PAC specifically reversed reflux-induced bacterial, inflammatory, and immune-implicated proteins and genes, including Ccl4, Cd14, Crp, Cxcl1, Il6, Il1b, Lbp, Lcn2, Myd88, Nfkb1, Tlr2, and Tlr4, aligning with changes in human EAC progression, as confirmed through public databases. C-PAC is a safe, promising dietary constituent that may be utilized alone or potentially as an adjuvant to current therapies to prevent EAC progression through ameliorating reflux-induced dysbiosis, inflammation, and cellular damage. |
| التعليقات: | Update of: bioRxiv. 2023 Aug 23;:. (PMID: 37662411) |
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| معلومات مُعتمدة: | R01 CA158319 United States CA NCI NIH HHS; R01 CA272898 United States CA NCI NIH HHS; U54 CA163059 United States CA NCI NIH HHS; R01 CA238433 United States CA NCI NIH HHS; R01 CA255298 United States CA NCI NIH HHS; U54 CA163004 United States CA NCI NIH HHS |
| فهرسة مساهمة: | Keywords: Cancer; Gastroenterology; NF-kappaB; Oncology; Transport |
| المشرفين على المادة: | 0 (Proanthocyanidins) |
| SCR Disease Name: | Adenocarcinoma Of Esophagus |
| تواريخ الأحداث: | Date Created: 20240208 Date Completed: 20240325 Latest Revision: 20240504 |
| رمز التحديث: | 20240504 |
| مُعرف محوري في PubMed: | PMC11063939 |
| DOI: | 10.1172/jci.insight.168112 |
| PMID: | 38329812 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2379-3708 |
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| DOI: | 10.1172/jci.insight.168112 |