دورية أكاديمية
Correlates of Rotavirus Vaccine Shedding and Seroconversion in a US Cohort of Healthy Infants.
| العنوان: | Correlates of Rotavirus Vaccine Shedding and Seroconversion in a US Cohort of Healthy Infants. |
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| المؤلفون: | Burke RM; Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia., Payne DC; Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia., McNeal M; Department of Pediatrics, University of Cincinnati College of Medicine.; Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center., Conrey SC; Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center.; Department of Environmental and Public Health Sciences, University of Cincinnati College of Medicine, Cincinnati, Ohio., Burrell AR; Department of Pediatrics, University of Cincinnati College of Medicine.; Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center.; Department of Environmental and Public Health Sciences, University of Cincinnati College of Medicine, Cincinnati, Ohio., Mattison CP; Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.; Cherokee Nation Assurance, Arlington, Virginia., Casey-Moore MC; Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia., Mijatovic-Rustempasic S; Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia., Gautam R; Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia., Esona MD; Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia., Thorman AW; Department of Environmental and Public Health Sciences, University of Cincinnati College of Medicine, Cincinnati, Ohio., Bowen MD; Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia., Parashar UD; Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia., Tate JE; Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia., Morrow AL; Department of Environmental and Public Health Sciences, University of Cincinnati College of Medicine, Cincinnati, Ohio., Staat MA; Department of Pediatrics, University of Cincinnati College of Medicine.; Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center. |
| المصدر: | The Journal of infectious diseases [J Infect Dis] 2024 Sep 23; Vol. 230 (3), pp. 754-762. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: United States NLM ID: 0413675 Publication Model: Print Cited Medium: Internet ISSN: 1537-6613 (Electronic) Linking ISSN: 00221899 NLM ISO Abbreviation: J Infect Dis Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Jan. 2011- : Oxford : Oxford University Press Original Publication: 1904-2010 : Chicago, IL : University of Chicago Press |
| مواضيع طبية MeSH: | Rotavirus Vaccines*/immunology , Rotavirus Vaccines*/administration & dosage , Virus Shedding* , Antibodies, Viral*/blood , Rotavirus*/immunology , Seroconversion* , Rotavirus Infections*/prevention & control , Rotavirus Infections*/immunology , Feces*/virology , Immunoglobulin G*/blood , Immunoglobulin G*/immunology, Humans ; Infant ; Female ; Male ; United States ; Immunoglobulin A/blood ; Immunoglobulin A/immunology ; Cohort Studies ; Longitudinal Studies ; Birth Cohort ; Adult ; Vaccination |
| مستخلص: | Background: Rotavirus is a leading cause of severe pediatric gastroenteritis; 2 highly effective vaccines are used in the United States (US). We aimed to identify correlates of immune response to rotavirus vaccination in a US cohort. Methods: Pediatric Respiratory and Enteric Virus Acquisition and Immunogenesis Longitudinal (PREVAIL) is a birth cohort of 245 mother-child pairs enrolled in 2017-2018 and followed for 2 years. Infant stool samples and symptom information were collected weekly. Shedding was defined as reverse-transcription polymerase chain reaction detection of rotavirus vaccine virus in stools collected 4-28 days after dose 1. Seroconversion was defined as a 3-fold rise in immunoglobulin A between the 6-week and 6-month blood draws. Correlates were analyzed using generalized estimating equations and logistic regression. Results: Prevaccination immunoglobulin G (IgG) (odds ratio [OR], 0.84 [95% confidence interval {CI}, .75-.94] per 100-unit increase) was negatively associated with shedding. Shedding was also less likely among infants with a single-nucleotide polymorphism inactivating FUT2 antigen secretion ("nonsecretors") with nonsecretor mothers, versus all other combinations (OR, 0.37 [95% CI, .16-.83]). Of 141 infants with data, 105 (74%) seroconverted; 78 (77%) had shed vaccine virus following dose 1. Prevaccination IgG and secretor status were significantly associated with seroconversion. Neither shedding nor seroconversion significantly differed by vaccine product. Conclusions: In this US cohort, prevaccination IgG and maternal and infant secretor status were associated with rotavirus vaccine response. Competing Interests: Potential conflicts of interest. The authors: No reported conflicts of interest. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed. (Published by Oxford University Press on behalf of Infectious Diseases Society of America 2024.) |
| معلومات مُعتمدة: | T32 ES010957 United States ES NIEHS NIH HHS; PREVAIL; IP16-004 US Centers for Disease Control and Prevention |
| فهرسة مساهمة: | Keywords: histo-blood group antigens (HBGA); pediatric gastroenteritis; rotavirus; rotavirus vaccine; vaccine immunogenicity; vaccine response; vaccine shedding |
| المشرفين على المادة: | 0 (Rotavirus Vaccines) 0 (Antibodies, Viral) 0 (Immunoglobulin G) 0 (Immunoglobulin A) |
| تواريخ الأحداث: | Date Created: 20240208 Date Completed: 20240924 Latest Revision: 20240924 |
| رمز التحديث: | 20240925 |
| DOI: | 10.1093/infdis/jiae055 |
| PMID: | 38330312 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1537-6613 |
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| DOI: | 10.1093/infdis/jiae055 |