دورية أكاديمية
Signatures of cysteine oxidation on muscle structural and contractile proteins are associated with physical performance and muscle function in older adults: Study of Muscle, Mobility and Aging (SOMMA).
| العنوان: | Signatures of cysteine oxidation on muscle structural and contractile proteins are associated with physical performance and muscle function in older adults: Study of Muscle, Mobility and Aging (SOMMA). |
|---|---|
| المؤلفون: | Day NJ; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, USA., Kelly SS; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, USA., Lui LY; San Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, California, USA., Mansfield TA; San Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, California, USA., Gaffrey MJ; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, USA., Trejo JB; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, USA., Sagendorf TJ; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, USA., Attah IK; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, USA., Moore RJ; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, USA., Douglas CM; Department of Physiology and Aging, University of Florida College of Medicine, Gainesville, Florida, USA., Newman AB; Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Kritchevsky SB; Department of Internal Medicine-Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA., Kramer PA; Department of Internal Medicine-Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA., Marcinek DJ; Department of Radiology, University of Washington, Seattle, Washington, USA., Coen PM; Translational Research Institute, AdventHealth, Orlando, Florida, USA., Goodpaster BH; Translational Research Institute, AdventHealth, Orlando, Florida, USA., Hepple RT; Department of Physical Therapy, University of Florida College of Medicine, Gainesville, Florida, USA., Cawthon PM; San Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, California, USA.; Department of Epidemiology and Biostatistics, University of California, San Francisco, California, USA., Petyuk VA; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, USA., Esser KA; Department of Physiology and Aging, University of Florida College of Medicine, Gainesville, Florida, USA., Qian WJ; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, USA., Cummings SR; San Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, California, USA.; Department of Epidemiology and Biostatistics, University of California, San Francisco, California, USA. |
| المصدر: | Aging cell [Aging Cell] 2024 Jun; Vol. 23 (6), pp. e14094. Date of Electronic Publication: 2024 Feb 08. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101130839 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1474-9726 (Electronic) Linking ISSN: 14749718 NLM ISO Abbreviation: Aging Cell Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Oxford, UK : Wiley-Blackwell Original Publication: Oxford, UK : Blackwell Pub., c2002- |
| مواضيع طبية MeSH: | Cysteine*/metabolism , Oxidation-Reduction* , Aging*/physiology , Aging*/metabolism, Humans ; Aged ; Male ; Female ; Physical Functional Performance ; Muscle, Skeletal/metabolism ; Muscle, Skeletal/physiology ; Contractile Proteins/metabolism ; Muscle Proteins/metabolism ; Aged, 80 and over |
| مستخلص: | Oxidative stress is considered a contributor to declining muscle function and mobility during aging; however, the underlying molecular mechanisms remain poorly described. We hypothesized that greater levels of cysteine (Cys) oxidation on muscle proteins are associated with decreased measures of mobility. Herein, we applied a novel redox proteomics approach to measure reversible protein Cys oxidation in vastus lateralis muscle biopsies collected from 56 subjects in the Study of Muscle, Mobility and Aging (SOMMA), a community-based cohort study of individuals aged 70 years and older. We tested whether levels of Cys oxidation on key muscle proteins involved in muscle structure and contraction were associated with muscle function (leg power and strength), walking speed, and fitness (VO (© 2024 Battelle Memorial Institute and The Authors. Aging Cell published by Anatomical Society and John Wiley & Sons Ltd.) |
| التعليقات: | Update of: medRxiv. 2023 Nov 08:2023.11.07.23298224. doi: 10.1101/2023.11.07.23298224. (PMID: 37986748) |
| References: | Antioxid Redox Signal. 2009 May;11(5):997-1014. (PMID: 18999917) Sci Adv. 2021 Dec 17;7(51):eabl4988. (PMID: 34910515) Am J Physiol Cell Physiol. 2017 Mar 1;312(3):C316-C327. (PMID: 27974300) Ageing Res Rev. 2012 Jan;11(1):136-49. (PMID: 22101330) Sports (Basel). 2019 Jul 11;7(7):. (PMID: 31336753) J Gerontol A Biol Sci Med Sci. 2023 Aug 2;78(8):1367-1375. (PMID: 36462195) Free Radic Biol Med. 2022 Nov 20;193(Pt 1):373-384. (PMID: 36306991) J Mol Biol. 2015 Nov 6;427(22):3527-3537. (PMID: 26362007) Front Physiol. 2015 Nov 25;6:347. (PMID: 26635632) J Gerontol A Biol Sci Med Sci. 2023 Oct 28;78(11):2083-2093. (PMID: 36754371) J Physiol. 1998 Jun 1;509 ( Pt 2):565-75. (PMID: 9575304) Bioinformatics. 2012 Mar 15;28(6):882-3. (PMID: 22257669) J Gerontol. 1956 Jul;11(3):298-300. (PMID: 13332224) PLoS One. 2013 Jul 19;8(7):e69110. (PMID: 23894416) J Sport Health Sci. 2020 Sep;9(5):415-425. (PMID: 32380253) EMBO J. 2000 Dec 1;19(23):6331-40. (PMID: 11101506) Physiol Genomics. 2007 Dec 19;32(1):58-63. (PMID: 17848603) Nat Protoc. 2014 Jan;9(1):64-75. (PMID: 24336471) Aging Cell. 2024 Jun;23(6):e14094. (PMID: 38332629) Am J Physiol Lung Cell Mol Physiol. 2023 May 1;324(5):L571-L583. (PMID: 36881561) Int J Mol Sci. 2023 Sep 26;24(19):. (PMID: 37834023) Cell. 2023 Jan 19;186(2):243-278. (PMID: 36599349) Redox Biol. 2018 Jul;17:367-376. (PMID: 29857311) Nat Commun. 2018 Jan 12;9(1):185. (PMID: 29330363) Nat Commun. 2019 Oct 11;10(1):4623. (PMID: 31604916) J Proteome Res. 2014 Nov 7;13(11):5008-21. (PMID: 25181601) Front Physiol. 2017 Dec 18;8:1080. (PMID: 29326606) Antioxidants (Basel). 2021 Mar 30;10(4):. (PMID: 33808211) Aging Cell. 2011 Dec;10(6):1047-55. (PMID: 21933339) Free Radic Biol Med. 2019 Apr;134:268-281. (PMID: 30597195) Redox Biol. 2021 Jun;42:101901. (PMID: 33744200) Cell. 2020 Mar 5;180(5):968-983.e24. (PMID: 32109415) Am J Pathol. 2023 Oct;193(10):1528-1547. (PMID: 37422147) Biochem J. 2016 Aug 15;473(16):2485-93. (PMID: 27287556) Am J Physiol Cell Physiol. 2006 Mar;290(3):C844-51. (PMID: 16251473) Med Sci Sports Exerc. 1982;14(1):101-2. (PMID: 7070249) Nat Genet. 1999 Apr;21(4):353-4. (PMID: 10192379) Am J Physiol Cell Physiol. 2021 Feb 1;320(2):C182-C194. (PMID: 33264075) Free Radic Biol Med. 2012 Feb 1;52(3):539-555. (PMID: 22080087) Am J Physiol Cell Physiol. 2022 Oct 01;323(4):C1206-C1214. (PMID: 36062880) Antioxidants (Basel). 2021 Mar 23;10(3):. (PMID: 33807006) Free Radic Biol Med. 2021 Dec;177:88-99. (PMID: 34655746) Nat Rev Cardiol. 2022 Jun;19(6):353-363. (PMID: 35304599) |
| فهرسة مساهمة: | Keywords: cysteine oxidation; fitness; muscle; posttranslational modifications; power; redox |
| المشرفين على المادة: | K848JZ4886 (Cysteine) 0 (Contractile Proteins) 0 (Muscle Proteins) |
| تواريخ الأحداث: | Date Created: 20240209 Date Completed: 20240611 Latest Revision: 20240708 |
| رمز التحديث: | 20240709 |
| مُعرف محوري في PubMed: | PMC11166363 |
| DOI: | 10.1111/acel.14094 |
| PMID: | 38332629 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1474-9726 |
|---|---|
| DOI: | 10.1111/acel.14094 |