دورية أكاديمية
Risk of attention deficit hyperactivity disorder diagnosis following multiple exposures to general anesthesia in the paediatric population: A systematic review and meta-analysis.
| العنوان: | Risk of attention deficit hyperactivity disorder diagnosis following multiple exposures to general anesthesia in the paediatric population: A systematic review and meta-analysis. |
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| المؤلفون: | Skakum M; University of Manitoba Master of Physician Assistant Studies Program, Department of Family Medicine, University of Manitoba, Winnipeg, Manitoba, Canada., Katako A; University of Manitoba Master of Physician Assistant Studies Program, Department of Family Medicine, University of Manitoba, Winnipeg, Manitoba, Canada., Mitchell-Dueck J; Children's Hospital Research Institute of Manitoba, Winnipeg, Manitoba, Canada., Ricci MF; Children's Hospital Research Institute of Manitoba, Winnipeg, Manitoba, Canada.; Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada.; Specialized Services for Children and Youth (SSCY) Centre, Winnipeg, Manitoba, Canada., Russell K; Children's Hospital Research Institute of Manitoba, Winnipeg, Manitoba, Canada.; Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada. |
| المصدر: | Paediatrics & child health [Paediatr Child Health] 2023 Nov 16; Vol. 29 (1), pp. 29-35. Date of Electronic Publication: 2023 Nov 16 (Print Publication: 2024). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: England NLM ID: 9815960 Publication Model: eCollection Cited Medium: Print ISSN: 1205-7088 (Print) Linking ISSN: 12057088 NLM ISO Abbreviation: Paediatr Child Health Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Publication: 2017- : Oxford : Oxford University Press Original Publication: [Oakville, Ont.] : PULSUS Group [for the] Canadian Paediatric Society, 1996- |
| مستخلص: | Objectives: The risk of attention deficit hyperactivity disorder (ADHD) following multiple exposures to anesthesia has been debated. Our objective was to systematically review the literature to examine the association between multiple exposures to general anesthesia before age 5 and subsequent diagnosis of ADHD. Methods: A systematic search of EMBASE, PubMed, and SCOPUS was performed using key search terms in February 2022. We included studies that: were published after 1980, included only otherwise healthy children who experienced two or more exposures to general anesthetic before age 5, diagnosed ADHD by a medical professional before age 19 years after exposure to general anesthetic, were cross-sectional, case-control, or cohort study, and were published in English. The results (expressed as hazard ratios [HR] and associated 95% confidence intervals [CI]) were pooled using meta-analytic techniques. Studies which did not present their results as HR and 95% CI were analyzed separately. GRADE was used to determine the certainty of the findings. PRISMA guidelines were followed at each stage of the review. Results: Eight studies (196,749 children) were included. Five reported HR and 95% CI and were subsequently pooled for meta-analysis. Multiple exposures to anesthesia were associated with diagnosis of ADHD before the 19th year of life (HR: 1.71; 95% CI: 1.59, 1.84). Two of the three studies not used in the meta-analysis also found an increased risk of ADHD diagnosis following multiple anesthetic exposures. Conclusions: There was an association between multiple early exposures to general anesthesia and later diagnosis of ADHD. Competing Interests: All authors: No reported conflicts of interest. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed. (© The Author(s) 2023. Published by Oxford University Press on behalf of the Canadian Paediatric Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.) |
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| فهرسة مساهمة: | Keywords: Anesthesia; Attention deficit hyperactivity disorder; Meta-analysis; Systematic review |
| تواريخ الأحداث: | Date Created: 20240209 Latest Revision: 20240210 |
| رمز التحديث: | 20240210 |
| مُعرف محوري في PubMed: | PMC10848114 |
| DOI: | 10.1093/pch/pxad074 |
| PMID: | 38332968 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1205-7088 |
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| DOI: | 10.1093/pch/pxad074 |