دورية أكاديمية
أعرض في EDS

Age-specific breast and ovarian cancer risks associated with germline BRCA1 or BRCA2 pathogenic variants - an Asian study of 572 families.

التفاصيل البيبلوغرافية
العنوان: Age-specific breast and ovarian cancer risks associated with germline BRCA1 or BRCA2 pathogenic variants - an Asian study of 572 families.
المؤلفون: Ho WK; School of Mathematical Sciences, Faculty of Science and Engineering, University of Nottingham Malaysia, Jalan Broga, Semenyih, 43500, Selangor, Malaysia.; Cancer Research Malaysia, 1 Jalan SS12/1A, Subang Jaya, 47500, Selangor, Malaysia., Hassan NT; Cancer Research Malaysia, 1 Jalan SS12/1A, Subang Jaya, 47500, Selangor, Malaysia., Yoon SY; Cancer Research Malaysia, 1 Jalan SS12/1A, Subang Jaya, 47500, Selangor, Malaysia., Yang X; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, CB1 8RN, Cambridge, UK., Lim JMC; Cancer Research Malaysia, 1 Jalan SS12/1A, Subang Jaya, 47500, Selangor, Malaysia., Binte Ishak ND; Cancer Genetics Service, National Cancer Centre Singapore, Singapore., Ho PJ; Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore.; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.; Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A∗STAR), 60 Biopolis Street, Genome, #02-01, Singapore, 138672, Singapore., Wijaya EA; Cancer Research Malaysia, 1 Jalan SS12/1A, Subang Jaya, 47500, Selangor, Malaysia., Ng PP; Cancer Research Malaysia, 1 Jalan SS12/1A, Subang Jaya, 47500, Selangor, Malaysia., Luccarini C; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, 2 Worts' Causeway, CB1 8RN, Cambridge, UK., Allen J; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, UK., Tai MC; Cancer Research Malaysia, 1 Jalan SS12/1A, Subang Jaya, 47500, Selangor, Malaysia., Chiang J; Cancer Genetics Service, National Cancer Centre Singapore, Singapore., Zhang Z; Cancer Genetics Service, National Cancer Centre Singapore, Singapore., See MH; Department of Surgery, Faculty of Medicine, University of Malaya, Jalan Universiti, Kuala Lumpur, 50630, Malaysia., Thong MK; Genetic Medicine Unit, University of Malaya Medical Center, Kuala Lumpur, Malaysia., Woo YL; Department of Obstetrics and Gynaecology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia., Dunning AM; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, 2 Worts' Causeway, CB1 8RN, Cambridge, UK., Hartman M; Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore.; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.; Department of Surgery, National University Hospital and National University Health System, Singapore, Singapore., Yip CH; Subang Jaya Medical Centre, 1 Jalan SS12/1A, Subang Jaya, 47500, Selangor, Malaysia., Mohd Taib NA; Department of Surgery, Faculty of Medicine, University of Malaya, Jalan Universiti, Kuala Lumpur, 50630, Malaysia.; University Malaya Cancer Research Institute, 50603, Kuala Lumpur, Malaysia., Easton DF; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, CB1 8RN, Cambridge, UK.; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, 2 Worts' Causeway, CB1 8RN, Cambridge, UK., Li J; Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore.; Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A∗STAR), 60 Biopolis Street, Genome, #02-01, Singapore, 138672, Singapore., Ngeow J; Cancer Genetics Service, National Cancer Centre Singapore, Singapore.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore., Antoniou AC; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, CB1 8RN, Cambridge, UK., Teo SH; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, CB1 8RN, Cambridge, UK.; Department of Surgery, Faculty of Medicine, University of Malaya, Jalan Universiti, Kuala Lumpur, 50630, Malaysia.
المصدر: The Lancet regional health. Western Pacific [Lancet Reg Health West Pac] 2024 Feb 05; Vol. 44, pp. 101017. Date of Electronic Publication: 2024 Feb 05 (Print Publication: 2024).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Ltd Country of Publication: England NLM ID: 101774968 Publication Model: eCollection Cited Medium: Internet ISSN: 2666-6065 (Electronic) Linking ISSN: 26666065 NLM ISO Abbreviation: Lancet Reg Health West Pac Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [London] : Elsevier Ltd., [2020]-
مستخلص: Background: Clinical management of Asian BRCA1 and BRCA2 pathogenic variants (PV) carriers remains challenging due to imprecise age-specific breast (BC) and ovarian cancer (OC) risks estimates. We aimed to refine these estimates using six multi-ethnic studies in Asia.
Methods: Data were collected on 271 BRCA1 and 301 BRCA2 families from Malaysia and Singapore, ascertained through population/hospital-based case-series (88%) and genetic clinics (12%). Age-specific cancer risks were estimated using a modified segregation analysis method, adjusted for ascertainment.
Findings: BC and OC relative risks (RRs) varied across age groups for both BRCA1 and BRCA 2. The age-specific RR estimates were similar across ethnicities and country of residence. For BRCA1 carriers of Malay, Indian and Chinese ancestry born between 1950 and 1959 in Malaysia, the cumulative risk (95% CI) of BC by age 80 was 40% (36%-44%), 49% (44%-53%) and 55% (51%-60%), respectively. The corresponding estimates for BRCA2 were 29% (26-32%), 36% (33%-40%) and 42% (38%-45%). The corresponding cumulative BC risks for Singapore residents from the same birth cohort, where the underlying population cancer incidences are higher compared to Malaysia, were higher, varying by ancestry group between 57 and 61% for BRCA1, and between 43 and 47% for BRCA2 carriers. The cumulative risk of OC by age 80 was 31% (27-36%) for BRCA1 and 12% (10%-15%) for BRCA2 carriers in Malaysia born between 1950 and 1959; and 42% (34-50%) for BRCA1 and 20% (14-27%) for BRCA2 carriers of the same birth cohort in Singapore. There was evidence of increased BC and OC risks for women from >1960 birth cohorts (p-value = 3.6 × 10 -5 for BRCA1 and 0.018 for BRCA 2).
Interpretation: The absolute age-specific cancer risks of Asian carriers vary depending on the underlying population-specific cancer incidences, and hence should be customised to allow for more accurate cancer risk management.
Funding: Wellcome Trust [grant no: v203477/Z/16/Z]; CRUK (PPRPGM-Nov20∖100002).
Competing Interests: Z.Z received honorarium from AstraZeneca. J.N received research funding from AstraZeneca and MiRXES. A.C.A is listed as creator of the BOADICEA model which has been licensed by Cambridge Enterprise, from which University of Cambridge may receive royalties. N.A.M.T received honoraria for lectures from Zuellig Pharma Sdn Bhd and Astra Zeneca, received support for attending meetings and/or travel from MSD and Astra Zeneca. S.Y.Y received speaker's honoraria from Astra Zeneca, she is the president of Genetic Counselling Society Malaysia.
(© 2024 The Author(s).)
References: Cancer Epidemiol Biomarkers Prev. 2019 Nov;28(11):1792-1801. (PMID: 31488412)
J Clin Oncol. 2006 Feb 20;24(6):863-71. (PMID: 16484695)
Clin Cancer Res. 2008 May 1;14(9):2861-9. (PMID: 18451254)
Genet Med. 2015 May;17(5):405-24. (PMID: 25741868)
Lancet Glob Health. 2020 Aug;8(8):e1027-e1037. (PMID: 32710860)
Genet Epidemiol. 1988;5(6):471-2. (PMID: 3061869)
JAMA Oncol. 2022 Jun 1;8(6):871-878. (PMID: 35420638)
Breast Cancer Res Treat. 2015 Aug;152(3):659-65. (PMID: 26195121)
Br J Cancer. 2008 Apr 22;98(8):1457-66. (PMID: 18349832)
J Natl Cancer Inst. 2015 Apr 13;107(7):. (PMID: 25868578)
JAMA. 2017 Jun 20;317(23):2402-2416. (PMID: 28632866)
Int J Cancer. 2005 Oct 20;117(1):145-9. (PMID: 15880571)
N Engl J Med. 2021 Feb 4;384(5):428-439. (PMID: 33471991)
Br J Cancer. 2000 Nov;83(10):1301-8. (PMID: 11044354)
Theor Popul Biol. 1986 Dec;30(3):388-412. (PMID: 3810507)
Eur J Cancer. 2013 Feb;49(3):703-9. (PMID: 23040889)
Br J Cancer. 2007 Jan 15;96(1):11-5. (PMID: 17213823)
N Engl J Med. 2014 Aug 7;371(6):497-506. (PMID: 25099575)
J Natl Cancer Inst. 2006 Apr 19;98(8):535-44. (PMID: 16622123)
J Med Genet. 1999 Apr;36(4):309-12. (PMID: 10227399)
J Med Genet. 2018 Feb;55(2):97-103. (PMID: 28993434)
Stat Med. 1991 Jul;10(7):1025-35. (PMID: 1652152)
Oncotarget. 2018 Feb 2;9(38):25025-25033. (PMID: 29861850)
Fam Cancer. 2004;3(1):1-10. (PMID: 15131399)
J Natl Compr Canc Netw. 2016 Feb;14(2):153-62. (PMID: 26850485)
J Med Genet. 2014 Feb;51(2):98-107. (PMID: 24285858)
Breast Cancer Res Treat. 2016 Apr;156(3):441-445. (PMID: 27033093)
Am J Hum Genet. 1988 Oct;43(4):387-95. (PMID: 3177381)
Clin Genet. 1977 Oct;12(4):208-12. (PMID: 334399)
Cancer Epidemiol Biomarkers Prev. 2007 Apr;16(4):740-6. (PMID: 17416765)
Cancer Epidemiol Biomarkers Prev. 2022 Aug 2;31(8):1593-1601. (PMID: 35654374)
Gynecol Oncol. 2016 May;141(2):318-322. (PMID: 26541979)
CMAJ. 2019 Aug 12;191(32):E886-E893. (PMID: 31405835)
Cancer. 2015 Jul 1;121(13):2108-20. (PMID: 25820366)
J Clin Oncol. 2007 Sep 1;25(25):3831-6. (PMID: 17635951)
Am J Hum Genet. 2003 May;72(5):1117-30. (PMID: 12677558)
J Clin Oncol. 2020 Mar 1;38(7):674-685. (PMID: 31841383)
فهرسة مساهمة: Keywords: BRCA1; BRCA2; Breast cancer risk; Ovarian cancer risk; Penetrance
تواريخ الأحداث: Date Created: 20240209 Latest Revision: 20240210
رمز التحديث: 20240210
مُعرف محوري في PubMed: PMC10851205
DOI: 10.1016/j.lanwpc.2024.101017
PMID: 38333895
قاعدة البيانات: MEDLINE
الوصف
تدمد:2666-6065
DOI:10.1016/j.lanwpc.2024.101017