دورية أكاديمية
أعرض في EDS

Coagulant Protein-Free Blood Coagulation Using Catechol-Conjugated Adhesive Chitosan/Gelatin Double Layer.

التفاصيل البيبلوغرافية
العنوان: Coagulant Protein-Free Blood Coagulation Using Catechol-Conjugated Adhesive Chitosan/Gelatin Double Layer.
المؤلفون: Kim S; R&D Center, InnoTherapy Inc., 25 Seonyu-ro 13-gil, Yeongdeungpo-gu, Seoul, 07282, Republic of Korea., Kim K; R&D Center, InnoTherapy Inc., 25 Seonyu-ro 13-gil, Yeongdeungpo-gu, Seoul, 07282, Republic of Korea., Koh MY; R&D Center, InnoTherapy Inc., 25 Seonyu-ro 13-gil, Yeongdeungpo-gu, Seoul, 07282, Republic of Korea., Do M; Department of Chemistry, Korea Advanced Institute of Science and Technology, 291 Daehak-ro, Yuseong-gu, Daejeon, 34141, Republic of Korea., Lee MS; R&D Center, InnoTherapy Inc., 25 Seonyu-ro 13-gil, Yeongdeungpo-gu, Seoul, 07282, Republic of Korea., Ryu JH; Department of Carbon Convergence Engineering, Smart Convergence Materials Analysis Center, Wonkwang University, 460 Iksan-daero, Iksan, Jeonbuk, 54538, Republic of Korea., Lee H; Department of Chemistry, Korea Advanced Institute of Science and Technology, 291 Daehak-ro, Yuseong-gu, Daejeon, 34141, Republic of Korea.
المصدر: Advanced healthcare materials [Adv Healthc Mater] 2024 Jun; Vol. 13 (14), pp. e2304004. Date of Electronic Publication: 2024 Feb 26.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101581613 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2192-2659 (Electronic) Linking ISSN: 21922640 NLM ISO Abbreviation: Adv Healthc Mater Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Weinheim : Wiley-VCH, 2012-
مواضيع طبية MeSH: Chitosan*/chemistry , Gelatin*/chemistry , Catechols*/chemistry , Catechols*/pharmacology , Blood Coagulation*/drug effects, Animals ; Hemostatics/chemistry ; Hemostatics/pharmacology ; Humans ; Adhesives/chemistry ; Adhesives/pharmacology
مستخلص: Since the discovery of polyphenolic underwater adhesion in marine mussels, researchers strive to emulate this natural phenomenon in the development of adhesive hemostatic materials. In this study, bio-inspired hemostatic materials that lead to pseudo-active blood coagulation, utilizing traditionally passive polymer matrices of chitosan and gelatin are developed. The two-layer configuration, consisting of a thin, blood-clotting catechol-conjugated chitosan (CHI-C) layer and a thick, barrier-functioning gelatin (Geln) ad-layer, maximizes hemostatic capability and usability. The unique combination of coagulant protein-free condition with CHI-C showcases not only coagulopathy-independent blood clotting properties (efficacy) but also exceptional clinical potential, meeting all necessary biocompatibility evaluation (safety) without inclusion of conventional coagulation triggering proteins such as thrombin or fibrinogen. As a result, the CHI-C/Geln is approved by the Ministry of Food and Drug Safety (MFDS, Republic of Korea) as a class II medical device. Hemostatic efficacy observed in multiple animal models further demonstrates the superiority of CHI-C/Geln sponges in achieving quick hemostasis compared to standard treatments. This study not only enriches the growing body of research on mussel-inspired materials but also emphasizes the potential of biomimicry in developing advanced medical materials, contributing a promising avenue toward development of readily accessible and affordable hemostatic materials.
(© 2024 Wiley‐VCH GmbH.)
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معلومات مُعتمدة: 2022R1A4A1031259 Korea government (MSIT); 22A0103L1 Korea government (MSIT and MHW)
فهرسة مساهمة: Keywords: bio‐inspired hemostatic materials; chitosan‐catechol; double‐layered hemostatic sponge; gelatin; pseudo‐active blood coagulation
المشرفين على المادة: 9012-76-4 (Chitosan)
9000-70-8 (Gelatin)
0 (Catechols)
LF3AJ089DQ (catechol)
0 (Hemostatics)
0 (Adhesives)
تواريخ الأحداث: Date Created: 20240209 Date Completed: 20240601 Latest Revision: 20240628
رمز التحديث: 20240628
DOI: 10.1002/adhm.202304004
PMID: 38334241
قاعدة البيانات: MEDLINE
الوصف
تدمد:2192-2659
DOI:10.1002/adhm.202304004