دورية أكاديمية
أعرض في EDS

Identification and Characterization of HIRIP3 as a Histone H2A Chaperone.

التفاصيل البيبلوغرافية
العنوان: Identification and Characterization of HIRIP3 as a Histone H2A Chaperone.
المؤلفون: Ignatyeva M; Département de Génomique Fonctionnelle et Cancer, Institut de Génétique et Biologie Moléculaire et Cellulaire (IG-BMC), CNRS UMR7104, INSERM U964, Université de Strasbourg, 67404 Illkirch, France., Patel AKM; Département de Génomique Fonctionnelle et Cancer, Institut de Génétique et Biologie Moléculaire et Cellulaire (IG-BMC), CNRS UMR7104, INSERM U964, Université de Strasbourg, 67404 Illkirch, France., Ibrahim A; Département de Génomique Fonctionnelle et Cancer, Institut de Génétique et Biologie Moléculaire et Cellulaire (IG-BMC), CNRS UMR7104, INSERM U964, Université de Strasbourg, 67404 Illkirch, France., Albiheyri RS; Centre of Excellence in Bionanoscience Research, King Abdulaziz University, Jeddah 21589, Saudi Arabia.; Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia., Zari AT; Centre of Excellence in Bionanoscience Research, King Abdulaziz University, Jeddah 21589, Saudi Arabia.; Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia., Bahieldin A; Centre of Excellence in Bionanoscience Research, King Abdulaziz University, Jeddah 21589, Saudi Arabia.; Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia., Bronner C; Département de Génomique Fonctionnelle et Cancer, Institut de Génétique et Biologie Moléculaire et Cellulaire (IG-BMC), CNRS UMR7104, INSERM U964, Université de Strasbourg, 67404 Illkirch, France., Sabir JSM; Centre of Excellence in Bionanoscience Research, King Abdulaziz University, Jeddah 21589, Saudi Arabia.; Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia., Hamiche A; Département de Génomique Fonctionnelle et Cancer, Institut de Génétique et Biologie Moléculaire et Cellulaire (IG-BMC), CNRS UMR7104, INSERM U964, Université de Strasbourg, 67404 Illkirch, France.; Centre of Excellence in Bionanoscience Research, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
المصدر: Cells [Cells] 2024 Feb 01; Vol. 13 (3). Date of Electronic Publication: 2024 Feb 01.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409 (Electronic) Linking ISSN: 20734409 NLM ISO Abbreviation: Cells Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI
مواضيع طبية MeSH: Histone Chaperones*/genetics , Histones*/metabolism, Animals ; Humans ; HeLa Cells ; Mammals/metabolism ; Molecular Chaperones/metabolism ; Saccharomyces cerevisiae/metabolism ; Serine ; Cell Cycle Proteins/genetics ; Cell Cycle Proteins/metabolism
مستخلص: HIRIP3 is a mammalian protein homologous to the yeast H2A.Z deposition chaperone Chz1. However, the structural basis underlying Chz's binding preference for H2A.Z over H2A, as well as the mechanism through which Chz1 modulates histone deposition or replacement, remains enigmatic. In this study, we aimed to characterize the function of HIRIP3 and to identify its interacting partners in HeLa cells. Our findings reveal that HIRIP3 is specifically associated in vivo with H2A-H2B dimers and CK2 kinase. While bacterially expressed HIRIP3 exhibited a similar binding affinity towards H2A and H2A.Z, the associated CK2 kinase showed a notable preference for H2A phosphorylation at serine 1. The recombinant HIRIP3 physically interacted with the H2A αC helix through an extended CHZ domain and played a crucial role in depositing the canonical core histones onto naked DNA. Our results demonstrate that mammalian HIRIP3 acts as an H2A histone chaperone, assisting in its selective phosphorylation by Ck2 kinase at serine 1 and facilitating its deposition onto chromatin.
References: Genes Dev. 2010 Jun 15;24(12):1253-65. (PMID: 20504901)
Mol Cell. 2007 Feb 9;25(3):357-68. (PMID: 17289584)
Nat Struct Mol Biol. 2013 Jan;20(1):14-22. (PMID: 23288364)
Mol Cell Biol. 1998 Sep;18(9):5546-56. (PMID: 9710638)
Biochim Biophys Acta. 2013 Mar-Apr;1819(3-4):211-221. (PMID: 24459723)
Mol Cell. 2001 Feb;7(2):283-92. (PMID: 11239457)
Cancer Lett. 2005 Mar 18;220(1):1-9. (PMID: 15737682)
Curr Protoc Pharmacol. 2006 Dec;Chapter 12:Unit12.3. (PMID: 22294172)
Mol Biosyst. 2015 Aug;11(8):2144-51. (PMID: 26088262)
Cell. 2013 Sep 26;155(1):94-106. (PMID: 24074863)
Cell Mol Biol Res. 1994;40(5-6):401-9. (PMID: 7735314)
Nature. 2014 Dec 11;516(7530):267-71. (PMID: 25252977)
Nucleic Acids Res. 2016 Nov 2;44(19):9142-9152. (PMID: 27369377)
Mol Cell. 2002 May;9(5):1091-100. (PMID: 12049744)
Mol Cell Biol. 2011 Oct;31(19):4107-18. (PMID: 21807893)
J Cell Biol. 2010 Nov 1;191(3):479-92. (PMID: 21041443)
Traffic. 2010 Feb;11(2):185-97. (PMID: 19929865)
Cell. 1997 Mar 7;88(5):593-602. (PMID: 9054499)
Nucleic Acids Res. 2012 Nov;40(21):10719-41. (PMID: 23002134)
Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1349-54. (PMID: 20080577)
Nat Struct Mol Biol. 2016 Apr;23(4):309-16. (PMID: 26974126)
EMBO J. 2001 Sep 17;20(18):5207-18. (PMID: 11566884)
Proc Natl Acad Sci U S A. 2003 Sep 2;100(18):10193-200. (PMID: 12925738)
Mol Cell Biol. 2011 Sep;31(18):3871-84. (PMID: 21791612)
N Am J Med Sci. 2012 Sep;4(9):429-34. (PMID: 23050259)
Genes Cells. 1997 Oct;2(10):593-600. (PMID: 9427281)
Dev Cell. 2005 Jan;8(1):19-30. (PMID: 15621527)
Mol Cell Biol. 2008 Feb;28(4):1313-25. (PMID: 18086883)
PLoS Biol. 2019 May 20;17(5):e3000277. (PMID: 31107867)
J Biol Chem. 1983 Oct 25;258(20):12675-84. (PMID: 6226660)
Nat Commun. 2020 Nov 11;11(1):5717. (PMID: 33177521)
Development. 2013 Jun;140(12):2513-24. (PMID: 23715545)
Curr Opin Genet Dev. 2006 Apr;16(2):104-11. (PMID: 16504499)
Biochem J. 2001 May 15;356(Pt 1):1-10. (PMID: 11336630)
J Vis Exp. 2007;(6):253. (PMID: 18997900)
Nat Struct Mol Biol. 2008 Aug;15(8):868-9. (PMID: 18641662)
Nucleic Acids Res. 2020 Jun 4;48(10):5383-5396. (PMID: 32374876)
Nature. 2014 Jan 30;505(7485):648-53. (PMID: 24463511)
N Am J Med Sci. 2012 Dec;4(12):651-5. (PMID: 23272309)
Biol Chem. 2007 Apr;388(4):391-8. (PMID: 17391060)
Biochem J. 2003 Jan 1;369(Pt 1):1-15. (PMID: 12396231)
Trends Genet. 2013 Nov;29(11):630-40. (PMID: 23830582)
Science. 1974 May 24;184(4139):868-71. (PMID: 4825889)
J Biol Chem. 1998 Mar 6;273(10):5858-68. (PMID: 9488723)
معلومات مُعتمدة: ANR-21-CE12-0017 RAHMAN Agence Nationale de la Recherche; IFPNC-005-130-2020 King Abdulaziz University
فهرسة مساهمة: Keywords: CK2 kinase; H2A; HIRIP3; histone chaperone
المشرفين على المادة: 0 (Histone Chaperones)
0 (Histones)
0 (Molecular Chaperones)
452VLY9402 (Serine)
0 (HIRIP3 protein, human)
0 (Cell Cycle Proteins)
تواريخ الأحداث: Date Created: 20240209 Date Completed: 20240214 Latest Revision: 20240226
رمز التحديث: 20240227
مُعرف محوري في PubMed: PMC10854748
DOI: 10.3390/cells13030273
PMID: 38334665
قاعدة البيانات: MEDLINE
الوصف
تدمد:2073-4409
DOI:10.3390/cells13030273