Neuroanatomical, electrophysiological, and morphological characterization of melanin-concentrating hormone cells coexpressing cocaine- and amphetamine-regulated transcript.

التفاصيل البيبلوغرافية
العنوان:	Neuroanatomical, electrophysiological, and morphological characterization of melanin-concentrating hormone cells coexpressing cocaine- and amphetamine-regulated transcript.
المؤلفون:	Miller PA; Department of Neuroscience, Carleton University, Ottawa, Ontario, Canada., Williams-Ikhenoba JG; Department of Neuroscience, Carleton University, Ottawa, Ontario, Canada., Sankhe AS; Department of Neuroscience, Carleton University, Ottawa, Ontario, Canada., Hoffe BH; Department of Neuroscience, Carleton University, Ottawa, Ontario, Canada., Chee MJ; Department of Neuroscience, Carleton University, Ottawa, Ontario, Canada.
المصدر:	The Journal of comparative neurology [J Comp Neurol] 2024 Feb; Vol. 532 (2), pp. e25588.
نوع المنشور:	Journal Article; Research Support, Non-U.S. Gov't
اللغة:	English
بيانات الدورية:	Publisher: Wiley-Liss Country of Publication: United States NLM ID: 0406041 Publication Model: Print Cited Medium: Internet ISSN: 1096-9861 (Electronic) Linking ISSN: 00219967 NLM ISO Abbreviation: J Comp Neurol Subsets: MEDLINE
أسماء مطبوعة:	Publication: <2003-> : Hoboken, N.J. : Wiley-Liss Original Publication: Philadelphia Wistar Institute of Anatomy and Biology
مواضيع طبية MeSH:	Cocaine* , Hypothalamic Hormones*/metabolism, Animals ; Female ; Male ; Mice ; Amphetamines/metabolism ; Hypothalamus/metabolism ; Melanins/metabolism ; Nerve Tissue Proteins/genetics ; Nerve Tissue Proteins/metabolism ; Neurons/metabolism ; Pituitary Hormones/metabolism
مستخلص:	Melanin-concentrating hormone (MCH) cells in the hypothalamus regulate fundamental physiological functions like energy balance, sleep, and reproduction. This diversity may be ascribed to the neurochemical heterogeneity among MCH cells. One prominent subpopulation of MCH cells coexpresses cocaine- and amphetamine-regulated transcript (CART), and as MCH and CART can have opposing actions, MCH/CART+ and MCH/CART- cells may differentially modulate behavioral outcomes. However, it is not known if there are differences in the cellular properties underlying their functional differences; thus, we compared the neuroanatomical, electrophysiological, and morphological properties of MCH cells in male and female Mch-cre;L10-Egfp reporter mice. Half of MCH cells expressed CART and were most prominent in the medial hypothalamus. Whole-cell patch-clamp recordings revealed differences in their passive and active membrane properties in a sex-dependent manner. Female MCH/CART+ cells had lower input resistances, but male cells largely differed in their firing properties. All MCH cells increased firing when stimulated, but their firing frequency decreases with sustained stimulation. MCH/CART+ cells showed stronger spike rate adaptation than MCH/CART- cells. The kinetics of excitatory events at MCH cells also differed by cell type, as the rising rate of excitatory events was slower at MCH/CART+ cells. By reconstructing the dendritic arborization of our recorded cells, we found no sex differences, but male MCH/CART+ cells had less dendritic length and fewer branch points. Overall, distinctions in topographical division and cellular properties between MCH cells add to their heterogeneity and help elucidate their response to stimuli or effect on modulating their respective neural networks. (© 2024 The Authors. The Journal of Comparative Neurology published by Wiley Periodicals LLC.)
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معلومات مُعتمدة:	Natural Sciences and Engineering Research Council of Canada; Carleton University; Province of Ontario
فهرسة مساهمة:	Keywords: CART; MCH; dendritic branching; electrical fingerprint; excitatory input; glutamate; lateral hypothalamus; neurokinin 3 receptor; sex difference
المشرفين على المادة:	0 (Amphetamines) I5Y540LHVR (Cocaine) 0 (Hypothalamic Hormones) 67382-96-1 (melanin-concentrating hormone) 0 (Melanins) 0 (Nerve Tissue Proteins) 0 (Pituitary Hormones) 0 (cocaine- and amphetamine-regulated transcript protein)
تواريخ الأحداث:	Date Created: 20240209 Date Completed: 20240214 Latest Revision: 20240426
رمز التحديث:	20240426
DOI:	10.1002/cne.25588
PMID:	38335050
قاعدة البيانات:	MEDLINE

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تدمد:	1096-9861
DOI:	10.1002/cne.25588