دورية أكاديمية
A meta-analysis of urinary transferrin for early diagnosis of diabetic nephropathy.
| العنوان: | A meta-analysis of urinary transferrin for early diagnosis of diabetic nephropathy. |
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| المؤلفون: | Li B; Department of Clinical Laboratory, People's Hospital of Changshan, Quzhou, China., Wang J; Department of Clinical Laboratory, The Second Affiliated Hospital of Hainan Medical University, Haikou, China., Ye W; Department of Clinical Laboratory, People's Hospital of Changshan, Quzhou, China. |
| المصدر: | Laboratory medicine [Lab Med] 2024 Jul 03; Vol. 55 (4), pp. 413-419. |
| نوع المنشور: | Journal Article; Meta-Analysis |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: England NLM ID: 0250641 Publication Model: Print Cited Medium: Internet ISSN: 1943-7730 (Electronic) Linking ISSN: 00075027 NLM ISO Abbreviation: Lab Med Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Oct. 2015- : Oxford, England: Oxford University Press Original Publication: Philadelphia, Lippincott. |
| مواضيع طبية MeSH: | Transferrin*/urine , Transferrin*/analysis , Diabetic Nephropathies*/diagnosis , Diabetic Nephropathies*/urine , Early Diagnosis* , Biomarkers*/urine, Humans ; Sensitivity and Specificity ; ROC Curve |
| مستخلص: | Objective: To assess the diagnostic value of urinary transferrin (Tf) in early diabetic nephropathy (DN) to propose a more sensitive and noninvasive biomarker for screening and monitoring DN in clinical practice. Methods: We searched 3 databases from their inception to May 2023, to identify studies investigating the diagnostic value of Tf in patients with DN. Meta-DiSc software, version 1.4, and Stata software, version 15.1 (StataCorp) were used to conduct a meta-analysis and evaluate the diagnostic accuracy of urine Tf levels for DN. Results: The meta-analysis included 6 relevant studies investigating the diagnostic value of Tf level for DN. Urinary Tf as a diagnostic marker demonstrated a combined sensitivity of 0.82 (95% CI, 0.71-0.89) and specificity of 0.88 (0.84-0.92). the positive diagnostic likelihood ratio was 7.07 (4.57-10.93), the negative diagnostic likelihood ratio was 0.20 (0.12-0.35), and the diagnostic odds ratio was 34.49 (13.61-87.44). Also, the area under the receiver operating characteristic curve was 0.92 (0.89-0.94), indicating that urinary Tf has a decent discriminative ability in diagnosing DN. Conclusion: Tf level is a valuable biological marker for early diagnosis and monitoring of DN in clinical practice. It has statistically significant predictive value for patients in the early phases of DN. (© The Author(s) 2024. Published by Oxford University Press on behalf of American Society for Clinical Pathology. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.) |
| فهرسة مساهمة: | Keywords: diabetic kidney disease; diagnostic value; early diagnosis; meta-analysis; transferrin; urine |
| المشرفين على المادة: | 0 (Transferrin) 0 (Biomarkers) |
| تواريخ الأحداث: | Date Created: 20240209 Date Completed: 20240703 Latest Revision: 20240715 |
| رمز التحديث: | 20240716 |
| DOI: | 10.1093/labmed/lmad115 |
| PMID: | 38335130 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1943-7730 |
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| DOI: | 10.1093/labmed/lmad115 |