دورية أكاديمية
أعرض في EDS

Vitamin K converting enzyme UBIAD1 plays an important role in osteogenesis and chondrogenesis in mice.

التفاصيل البيبلوغرافية
العنوان: Vitamin K converting enzyme UBIAD1 plays an important role in osteogenesis and chondrogenesis in mice.
المؤلفون: Hirashima S; Laboratory of Hygienic Sciences, Faculty of Pharmaceutical Sciences, Kobe Gakuin University, 1-1-3, Minatojima, Chuo-ku, Kobe Hyogo, 650-8586, Japan., Kiyooka Y; Laboratory of Hygienic Sciences, Faculty of Pharmaceutical Sciences, Kobe Gakuin University, 1-1-3, Minatojima, Chuo-ku, Kobe Hyogo, 650-8586, Japan., Kaetsu S; Laboratory of Hygienic Sciences, Faculty of Pharmaceutical Sciences, Kobe Gakuin University, 1-1-3, Minatojima, Chuo-ku, Kobe Hyogo, 650-8586, Japan., Nakagawa K; Laboratory of Hygienic Sciences, Faculty of Pharmaceutical Sciences, Kobe Gakuin University, 1-1-3, Minatojima, Chuo-ku, Kobe Hyogo, 650-8586, Japan. Electronic address: kimie-naka@pharm.kobegakuin.ac.jp.
المصدر: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2024 Apr 02; Vol. 702, pp. 149635. Date of Electronic Publication: 2024 Feb 05.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 0372516 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2104 (Electronic) Linking ISSN: 0006291X NLM ISO Abbreviation: Biochem Biophys Res Commun Subsets: MEDLINE
أسماء مطبوعة: Publication: <2002- >: San Diego, CA : Elsevier
Original Publication: New York, Academic Press.
مواضيع طبية MeSH: Vitamin K*/metabolism , Dimethylallyltranstransferase*/genetics , Dimethylallyltranstransferase*/metabolism, Animals ; Mice ; Osteogenesis ; Chondrogenesis ; Vitamin K 1/pharmacology
مستخلص: Dietary vitamin K 1 (phylloquinone: PK) and menaquinone (MK-n) are converted to menadione (MD) in the small intestine and then translocated to various tissues where they are converted to vitamin K 2 (menaquinone-4: MK-4) by UbiA prenyltransferase domain containing protein 1 (UBIAD1). MK-4 is effective in bone formation and is used to treat osteoporosis in Japan. UBIAD1 is expressed in bone and osteoblasts and shows conversion to MK-4, but the role of UBIAD1 in osteogenesis is unknown. In this study, we investigated the function of UBIAD1 in osteogenesis using a tamoxifen-dependent UBIAD1-deficient mouse model. When UBIAD1 deficiency was induced from the first week of life, the femur was significantly shortened, and bone mineral density (BMD) was reduced. In addition, the expression of bone and chondrocyte matrix proteins and chondrocyte differentiation factors was significantly decreased. In primary cultured chondrocytes, chondrocyte differentiation was significantly reduced by UBIAD1 deficiency. These results suggest that UBIAD1 is an important factor for the regulation of chondrocyte proliferation and differentiation during osteogenesis.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Inc. All rights reserved.)
فهرسة مساهمة: Keywords: Chondrogenesis; Menaquinone-4; Osteogenesis; UBIAD1; Vitamin K
المشرفين على المادة: 12001-79-5 (Vitamin K)
EC 2.5.1.1 (Dimethylallyltranstransferase)
84-80-0 (Vitamin K 1)
تواريخ الأحداث: Date Created: 20240209 Date Completed: 20240226 Latest Revision: 20240226
رمز التحديث: 20240226
DOI: 10.1016/j.bbrc.2024.149635
PMID: 38335702
قاعدة البيانات: MEDLINE
الوصف
تدمد:1090-2104
DOI:10.1016/j.bbrc.2024.149635