دورية أكاديمية
Modulation of extrinsic apoptotic pathway by intracellular glycosylation.
| العنوان: | Modulation of extrinsic apoptotic pathway by intracellular glycosylation. |
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| المؤلفون: | Seyrek K; Translational Inflammation Research, Medical Faculty, Center of Dynamic Systems (CDS), Otto von Guericke University Magdeburg, 39106 Magdeburg, Germany., Ivanisenko NV; Translational Inflammation Research, Medical Faculty, Center of Dynamic Systems (CDS), Otto von Guericke University Magdeburg, 39106 Magdeburg, Germany., König C; Translational Inflammation Research, Medical Faculty, Center of Dynamic Systems (CDS), Otto von Guericke University Magdeburg, 39106 Magdeburg, Germany., Lavrik IN; Translational Inflammation Research, Medical Faculty, Center of Dynamic Systems (CDS), Otto von Guericke University Magdeburg, 39106 Magdeburg, Germany. Electronic address: inna.lavrik@med.ovgu.de. |
| المصدر: | Trends in cell biology [Trends Cell Biol] 2024 Feb 08. Date of Electronic Publication: 2024 Feb 08. |
| Publication Model: | Ahead of Print |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Publishers Country of Publication: England NLM ID: 9200566 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3088 (Electronic) Linking ISSN: 09628924 NLM ISO Abbreviation: Trends Cell Biol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Cambridge, UK : Elsevier Science Publishers, c1991- |
| مستخلص: | The importance of post-translational modifications (PTMs), particularly O-GlcNAcylation, of cytoplasmic proteins in apoptosis has been neglected for quite a while. Modification of cytoplasmic proteins by a single N-acetylglucosamine sugar is a dynamic and reversible PTM exhibiting properties more like phosphorylation than classical O- and N-linked glycosylation. Due to the sparse information existing, we have only limited understanding of how GlcNAcylation affects cell death. Deciphering the role of GlcNAcylation in cell fate may provide further understanding of cell fate decisions. This review focus on the modulation of extrinsic apoptotic pathway via GlcNAcylation carried out by O-GlcNAc transferase (OGT) or by other bacterial effector proteins. Competing Interests: Declaration of interests No interests are declared. (Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.) |
| فهرسة مساهمة: | Keywords: NleB; O-GlcNAcylation; OGA; OGT; SseK; apoptosis |
| تواريخ الأحداث: | Date Created: 20240209 Latest Revision: 20240209 |
| رمز التحديث: | 20240210 |
| DOI: | 10.1016/j.tcb.2024.01.003 |
| PMID: | 38336591 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1879-3088 |
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| DOI: | 10.1016/j.tcb.2024.01.003 |