دورية أكاديمية
Loss of Calponin 2 causes premature ovarian insufficiency in mice.
| العنوان: | Loss of Calponin 2 causes premature ovarian insufficiency in mice. |
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| المؤلفون: | Hsieh TB; Department of Obstetrics & Gynecology, Wayne State University School of Medicine, Detroit, MI, 48201, USA., Jin JP; Department of Obstetrics & Gynecology, Wayne State University School of Medicine, Detroit, MI, 48201, USA. jpjin@uic.edu.; Department of Physiology, Wayne State University School of Medicine, Detroit, MI, 48201, USA. jpjin@uic.edu.; Department of Physiology and Biophysics, University of Illinois at Chicago College of Medicine, Chicago, IL, 60612, USA. jpjin@uic.edu. |
| المصدر: | Journal of ovarian research [J Ovarian Res] 2024 Feb 09; Vol. 17 (1), pp. 37. Date of Electronic Publication: 2024 Feb 09. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: BioMed Central Country of Publication: England NLM ID: 101474849 Publication Model: Electronic Cited Medium: Internet ISSN: 1757-2215 (Electronic) Linking ISSN: 17572215 NLM ISO Abbreviation: J Ovarian Res Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [London] : BioMed Central, c2008- |
| مواضيع طبية MeSH: | Calponins*/genetics , Calponins*/metabolism , Primary Ovarian Insufficiency*/genetics , Primary Ovarian Insufficiency*/metabolism, Adult ; Animals ; Female ; Humans ; Mice ; Actins/genetics ; Actins/metabolism ; Menopause, Premature ; Mice, Knockout |
| مستخلص: | Background: Premature ovarian insufficiency (POI) is a condition defined as women developing menopause before 40 years old. These patients display low ovarian reserve at young age and difficulties to conceive even with assisted reproductive technology. The pathogenesis of ovarian insufficiency is not fully understood. Genetic factors may underlie most of the cases. Actin cytoskeleton plays a pivotal role in ovarian folliculogenesis. Calponin 2 encoded by the Cnn2 gene is an actin associated protein that regulates motility and mechanical signaling related cellular functions. Results: The present study compared breeding of age-matched calponin 2 knockout (Cnn2-KO) and wild type (WT) mice and found that Cnn2-KO mothers had significantly smaller litter sizes. Ovaries from 4 weeks old Cnn2-KO mice showed significantly lower numbers of total ovarian follicles than WT control with the presence of multi-oocyte follicles. Cnn2-KO mice also showed age-progressive earlier depletion of ovarian follicles. Cnn2 expression is detected in the cumulus cells of the ovarian follicles of WT mice and colocalizes with actin stress fiber, tropomyosin and myosin II in primary cultures of cumulus cells. Conclusions: The findings demonstrate that the loss of calponin 2 impairs ovarian folliculogenesis with premature depletion of ovarian follicles. The role of calponin 2 in ovarian granulosa cells suggests a molecular target for further investigations on the pathogenesis of POI and for therapeutic development. (© 2024. The Author(s).) |
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| معلومات مُعتمدة: | R01 HL127691 United States HL NHLBI NIH HHS; R01 HL133162 United States HL NHLBI NIH HHS; HL-133162; HL127691 United States NH NIH HHS |
| فهرسة مساهمة: | Keywords: Calponin 2; Cytoskeleton; Granulosa cells; Premature ovarian insufficiency |
| المشرفين على المادة: | 0 (Actins) 0 (Calponins) 0 (Cnn2 protein, mouse) |
| تواريخ الأحداث: | Date Created: 20240209 Date Completed: 20240215 Latest Revision: 20240215 |
| رمز التحديث: | 20240215 |
| مُعرف محوري في PubMed: | PMC10854048 |
| DOI: | 10.1186/s13048-024-01346-y |
| PMID: | 38336796 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1757-2215 |
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| DOI: | 10.1186/s13048-024-01346-y |