دورية أكاديمية
أعرض في EDS

Effects of vasodilators on beat-to-beat and every fifteen minutes blood pressure variability induced by noradrenaline infusion in rats.

التفاصيل البيبلوغرافية
العنوان: Effects of vasodilators on beat-to-beat and every fifteen minutes blood pressure variability induced by noradrenaline infusion in rats.
المؤلفون: Jiang D; Frontier Science Research Center, University of Miyazaki Faculty of Medicine, Miyazaki, 889-1692, Japan., Matsuzaki M; Frontier Science Research Center, University of Miyazaki Faculty of Medicine, Miyazaki, 889-1692, Japan., Ida T; Frontier Science Research Center, University of Miyazaki Faculty of Medicine, Miyazaki, 889-1692, Japan., Kitamura K; Frontier Science Research Center, University of Miyazaki Faculty of Medicine, Miyazaki, 889-1692, Japan., Kato J; Frontier Science Research Center, University of Miyazaki Faculty of Medicine, Miyazaki, 889-1692, Japan. jkjpn@med.miyazaki-u.ac.jp.
المصدر: Hypertension research : official journal of the Japanese Society of Hypertension [Hypertens Res] 2024 Apr; Vol. 47 (4), pp. 1017-1023. Date of Electronic Publication: 2024 Feb 09.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 9307690 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1348-4214 (Electronic) Linking ISSN: 09169636 NLM ISO Abbreviation: Hypertens Res Subsets: MEDLINE
أسماء مطبوعة: Publication: 2009- : London : Nature Publishing Group
Original Publication: Toyonaka, Japan : The Society, c1992-2003
مواضيع طبية MeSH: Vasodilator Agents*/pharmacology , Norepinephrine*/pharmacology , Dihydropyridines*, Azetidinecarboxylic Acid/*analogs & derivatives, Rats ; Animals ; Blood Pressure ; Rats, Wistar ; Hydralazine/pharmacology
مستخلص: Increased blood pressure variability (BPV) was shown to be associated with cardiovascular morbidities and/or mortalities. There are various types of BPV depending on time intervals of BP measurements, ranging from beat-to-beat to visit-to-visit or year-to-year. We previously found that continuous infusion of noradrenaline (NA) for 14 days increased short-term BPV every 15 min in rats. The aims of this study were to examine (1) whether NA infusion increases very short-term beat-to-beat BPV, (2) the effects of azelnidipine and hydralazine on NA-induced BPV, and (3) whether baroreceptor reflex sensitivity (BRS) is affected by NA or NA plus those vasodilators. Nine-week-old Wistar rats infused subcutaneously with 30 μg/h NA were orally treated with or without 9.7 mg/day azelnidipine or 5.9 mg/day hydralazine over 14 days. BP levels were continuously monitored via abdominal aortic catheter with a telemetry system in an unrestrained condition. Standard deviations (SDs) were used to evaluate beat-to-beat BPV and BPV every 15 min which was obtained by averaging BP levels for 10-s segment at each time point. BRS was determined by a sequence analysis. Continuous NA infusion over 14 days increased average BP, beat-to-beat BPV, and BPV every 15 min, lowering BRS. Comparing the two vasodilators, hydralazine reduced BP elevation by NA; meanwhile, azelnidipine alleviated BPV augmentation, preserving BRS, despite a smaller BP reduction. Thus, NA infusion increased both very short- and short-term BPV concomitantly with impaired BRS, while azelnidipine had an inhibitory effect, possibly independent of BP-lowering, on those types of BPV and impairment of BRS.
(© 2024. The Author(s).)
التعليقات: Comment in: Hypertens Res. 2024 Mar 11;:. (PMID: 38467799)
References: J Hypertens. 2014 Sep;32(9):1898-904. (PMID: 24979307)
Ann N Y Acad Sci. 2006 Aug;1073:86-93. (PMID: 17102075)
Hypertension. 2000 Nov;36(5):901-6. (PMID: 11082164)
Am J Physiol. 1988 Feb;254(2 Pt 2):H377-83. (PMID: 3344828)
Hypertension. 1999 Sep;34(3):461-5. (PMID: 10489394)
Clin Exp Hypertens. 2016;38(8):721-724. (PMID: 27936949)
Hypertens Res. 2018 Aug;41(8):547-552. (PMID: 29880837)
Eur J Pharmacol. 2017 Jul 5;806:91-95. (PMID: 28419822)
Circulation. 2006 Mar 7;113(9):1213-25. (PMID: 16476843)
Hypertens Res. 2014 Sep;37(9):836-44. (PMID: 24942766)
Hypertens Res. 2003 Mar;26(3):201-8. (PMID: 12675275)
Lancet. 2010 Mar 13;375(9718):895-905. (PMID: 20226988)
J Renin Angiotensin Aldosterone Syst. 2023 Jan 4;2023:4201342. (PMID: 36704758)
Hypertension. 2017 Nov;70(5):862-866. (PMID: 28947617)
Curr Opin Cardiol. 2006 Sep;21(5):486-91. (PMID: 16900013)
Hypertens Res. 2020 Jul;43(7):609-620. (PMID: 32203448)
Clin Pharmacol Ther. 1980 Dec;28(6):736-42. (PMID: 7438689)
Curr Hypertens Rep. 2014 Jul;16(7):442. (PMID: 24792093)
Hypertension. 2015 Jun;65(6):1163-9; discussion 1169. (PMID: 25916727)
Am J Hypertens. 2016 Feb;29(2):163-9. (PMID: 26112866)
Hypertension. 2011 Feb;57(2):160-6. (PMID: 21200000)
Neuron. 2009 Dec 24;64(6):885-97. (PMID: 20064394)
Hypertension. 2009 Oct;54(4):832-8. (PMID: 19704105)
Curr Hypertens Rep. 2023 May;25(5):61-70. (PMID: 36892734)
Lancet Neurol. 2010 May;9(5):469-80. (PMID: 20227347)
J Hypertens. 2020 Feb;38(2):314-321. (PMID: 31503135)
J Hypertens. 2005 Nov;23(11):2033-9. (PMID: 16208146)
Hypertension. 2012 Aug;60(2):512-7. (PMID: 22733459)
فهرسة مساهمة: Keywords: Azelnidipine; Baroreceptor reflex sensitivity; Blood pressure variability; Hydralazine; Noradrenaline
المشرفين على المادة: PV23P19YUG (azelnidipine)
0 (Vasodilator Agents)
X4W3ENH1CV (Norepinephrine)
26NAK24LS8 (Hydralazine)
5GZ3E0L9ZU (Azetidinecarboxylic Acid)
0 (Dihydropyridines)
تواريخ الأحداث: Date Created: 20240209 Date Completed: 20240408 Latest Revision: 20240506
رمز التحديث: 20240507
مُعرف محوري في PubMed: PMC10994831
DOI: 10.1038/s41440-024-01595-w
PMID: 38337004
قاعدة البيانات: MEDLINE
الوصف
تدمد:1348-4214
DOI:10.1038/s41440-024-01595-w