دورية أكاديمية
Effects of vasodilators on beat-to-beat and every fifteen minutes blood pressure variability induced by noradrenaline infusion in rats.
العنوان: | Effects of vasodilators on beat-to-beat and every fifteen minutes blood pressure variability induced by noradrenaline infusion in rats. |
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المؤلفون: | Jiang D; Frontier Science Research Center, University of Miyazaki Faculty of Medicine, Miyazaki, 889-1692, Japan., Matsuzaki M; Frontier Science Research Center, University of Miyazaki Faculty of Medicine, Miyazaki, 889-1692, Japan., Ida T; Frontier Science Research Center, University of Miyazaki Faculty of Medicine, Miyazaki, 889-1692, Japan., Kitamura K; Frontier Science Research Center, University of Miyazaki Faculty of Medicine, Miyazaki, 889-1692, Japan., Kato J; Frontier Science Research Center, University of Miyazaki Faculty of Medicine, Miyazaki, 889-1692, Japan. jkjpn@med.miyazaki-u.ac.jp. |
المصدر: | Hypertension research : official journal of the Japanese Society of Hypertension [Hypertens Res] 2024 Apr; Vol. 47 (4), pp. 1017-1023. Date of Electronic Publication: 2024 Feb 09. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 9307690 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1348-4214 (Electronic) Linking ISSN: 09169636 NLM ISO Abbreviation: Hypertens Res Subsets: MEDLINE |
أسماء مطبوعة: | Publication: 2009- : London : Nature Publishing Group Original Publication: Toyonaka, Japan : The Society, c1992-2003 |
مواضيع طبية MeSH: | Vasodilator Agents*/pharmacology , Norepinephrine*/pharmacology , Dihydropyridines*, Azetidinecarboxylic Acid/*analogs & derivatives, Rats ; Animals ; Blood Pressure ; Rats, Wistar ; Hydralazine/pharmacology |
مستخلص: | Increased blood pressure variability (BPV) was shown to be associated with cardiovascular morbidities and/or mortalities. There are various types of BPV depending on time intervals of BP measurements, ranging from beat-to-beat to visit-to-visit or year-to-year. We previously found that continuous infusion of noradrenaline (NA) for 14 days increased short-term BPV every 15 min in rats. The aims of this study were to examine (1) whether NA infusion increases very short-term beat-to-beat BPV, (2) the effects of azelnidipine and hydralazine on NA-induced BPV, and (3) whether baroreceptor reflex sensitivity (BRS) is affected by NA or NA plus those vasodilators. Nine-week-old Wistar rats infused subcutaneously with 30 μg/h NA were orally treated with or without 9.7 mg/day azelnidipine or 5.9 mg/day hydralazine over 14 days. BP levels were continuously monitored via abdominal aortic catheter with a telemetry system in an unrestrained condition. Standard deviations (SDs) were used to evaluate beat-to-beat BPV and BPV every 15 min which was obtained by averaging BP levels for 10-s segment at each time point. BRS was determined by a sequence analysis. Continuous NA infusion over 14 days increased average BP, beat-to-beat BPV, and BPV every 15 min, lowering BRS. Comparing the two vasodilators, hydralazine reduced BP elevation by NA; meanwhile, azelnidipine alleviated BPV augmentation, preserving BRS, despite a smaller BP reduction. Thus, NA infusion increased both very short- and short-term BPV concomitantly with impaired BRS, while azelnidipine had an inhibitory effect, possibly independent of BP-lowering, on those types of BPV and impairment of BRS. (© 2024. The Author(s).) |
التعليقات: | Comment in: Hypertens Res. 2024 Mar 11;:. (PMID: 38467799) |
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فهرسة مساهمة: | Keywords: Azelnidipine; Baroreceptor reflex sensitivity; Blood pressure variability; Hydralazine; Noradrenaline |
المشرفين على المادة: | PV23P19YUG (azelnidipine) 0 (Vasodilator Agents) X4W3ENH1CV (Norepinephrine) 26NAK24LS8 (Hydralazine) 5GZ3E0L9ZU (Azetidinecarboxylic Acid) 0 (Dihydropyridines) |
تواريخ الأحداث: | Date Created: 20240209 Date Completed: 20240408 Latest Revision: 20240506 |
رمز التحديث: | 20240507 |
مُعرف محوري في PubMed: | PMC10994831 |
DOI: | 10.1038/s41440-024-01595-w |
PMID: | 38337004 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1348-4214 |
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DOI: | 10.1038/s41440-024-01595-w |