دورية أكاديمية
أعرض في EDS

Recipient Pericardial Apolipoprotein Levels Might Be an Indicator of Worse Outcomes after Orthotopic Heart Transplantation.

التفاصيل البيبلوغرافية
العنوان: Recipient Pericardial Apolipoprotein Levels Might Be an Indicator of Worse Outcomes after Orthotopic Heart Transplantation.
المؤلفون: Székely A; Department of Anesthesiology and Intensive Therapy, Semmelweis University, 1085 Budapest, Hungary.; Heart and Vascular Center, Semmelweis University, 1085 Budapest, Hungary., Pállinger É; Department of Genetics, Cell- and Immunobiology, Semmelweis University, 1085 Budapest, Hungary., Töreki E; Faculty of Medicine, Semmelweis University, 1085 Budapest, Hungary., Ifju M; Faculty of Medicine, Semmelweis University, 1085 Budapest, Hungary., Barta BA; Heart and Vascular Center, Semmelweis University, 1085 Budapest, Hungary., Szécsi B; Doctoral School of Theoretical and Translational Medicine, Semmelweis University, 1085 Budapest, Hungary., Losoncz E; Doctoral School of Theoretical and Translational Medicine, Semmelweis University, 1085 Budapest, Hungary., Dohy Z; Heart and Vascular Center, Semmelweis University, 1085 Budapest, Hungary., Barabás IJ; Heart and Vascular Center, Semmelweis University, 1085 Budapest, Hungary., Kosztin A; Heart and Vascular Center, Semmelweis University, 1085 Budapest, Hungary., Buzas EI; Department of Genetics, Cell- and Immunobiology, Semmelweis University, 1085 Budapest, Hungary.; HCEMM-SU Extracellular Vesicle Research Group, Semmelweis University, 1085 Budapest, Hungary.; HUN-REN-SU Translational Extracellular Vesicle Research Group, Semmelweis University, 1085 Budapest, Hungary., Radovits T; Heart and Vascular Center, Semmelweis University, 1085 Budapest, Hungary., Merkely B; Heart and Vascular Center, Semmelweis University, 1085 Budapest, Hungary.
المصدر: International journal of molecular sciences [Int J Mol Sci] 2024 Feb 01; Vol. 25 (3). Date of Electronic Publication: 2024 Feb 01.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2000-
مواضيع طبية MeSH: Heart Transplantation*/adverse effects , Heart Transplantation*/methods , Lung Transplantation*, Humans ; Tissue Donors ; Risk Factors ; Apolipoproteins ; Retrospective Studies ; Graft Rejection/etiology
مستخلص: Background: End-stage heart failure (ESHF) leads to hypoperfusion and edema formation throughout the body and is accompanied by neurohormonal and immunological alterations. Orthotopic heart transplantation (HTX) has been used as a beneficial option for ESHF. Due to the shortage of donor hearts, the ideal matching and timing of donors and recipients has become more important.
Purpose: In this study, our aim was to explore the relationship between the clinical outcomes of HTX and the cytokine and apolipoprotein profiles of the recipient pericardial fluid obtained at heart transplantation after opening the pericardial sac.
Materials and Methods: The clinical data and the interleukin, adipokine, and lipoprotein levels in the pericardial fluid of twenty HTX recipients were investigated. Outcome variables included primer graft dysfunction (PGD), the need for post-transplantation mechanical cardiac support (MCS), International Society for Heart and Lung Transplantation grade ≥2R rejection, and mortality. Recipient risk scores were also investigated.
Results: Leptin levels were significantly lower in patients with PGD than in those without PGD (median: 6.36 (IQR: 5.55-6.62) versus 7.54 (IQR = 6.71-10.44); p = 0.029). Higher ApoCII levels (median: 14.91 (IQR: 11.55-21.30) versus 10.31 (IQR = 10.02-13.07); p = 0.042) and ApoCIII levels (median: 60.32 (IQR: 43.00-81.66) versus 22.84 (IQR = 15.84-33.39); p = 0.005) were found in patients ( n = 5) who died in the first 5 years after HTX. In patients who exhibited rejection ( n = 4) in the first month after transplantation, the levels of adiponectin (median: 74.48 (IQR: 35.51-131.70) versus 29.96 (IQR: 19.86-42.28); p = 0.039), ApoCII (median: 20.11 (IQR: 13.06-23.54) versus 10.32 (IQR: 10.02-12.84); p = 0.007), and ApoCIII (median: 70.97 (IQR: 34.72-82.22) versus 26.33 (IQR: 17.18-40.17); p = 0.029) were higher than in the nonrejection group. Moreover, the pericardial thyroxine (T4) levels (median: 3.96 (IQR: 3.49-4.46) versus 4.69 (IQR: 4.23-5.77); p = 0.022) were lower in patients with rejection than in patients who did not develop rejection.
Conclusion: Our results indicate that apolipoproteins can facilitate the monitoring of rejection and could be a useful tool in the forecasting of early and late complications.
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معلومات مُعتمدة: RRF-2.3.1-21-2022-00003 European Union; NKFIH-1277-2/2020 Ministry for Innovation and Technology
فهرسة مساهمة: Keywords: apolipoprotein; heart transplantation; interleukin; organ recipient; primary graft dysfunction
المشرفين على المادة: 0 (Apolipoproteins)
تواريخ الأحداث: Date Created: 20240210 Date Completed: 20240214 Latest Revision: 20240214
رمز التحديث: 20240214
مُعرف محوري في PubMed: PMC10855207
DOI: 10.3390/ijms25031752
PMID: 38339027
قاعدة البيانات: MEDLINE
الوصف
تدمد:1422-0067
DOI:10.3390/ijms25031752