دورية أكاديمية
أعرض في EDS

Clinical Characteristics and Local Histopathological Modulators of Endometriosis and Its Progression.

التفاصيل البيبلوغرافية
العنوان: Clinical Characteristics and Local Histopathological Modulators of Endometriosis and Its Progression.
المؤلفون: Istrate-Ofiţeru AM; Department of Histology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.; Research Centre for Microscopic Morphology and Immunology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.; Department of Obstetrics and Gynecology, University Emergency County Hospital, 200642 Craiova, Romania., Mogoantă CA; ENT Department, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania., Zorilă GL; Department of Obstetrics and Gynecology, University Emergency County Hospital, 200642 Craiova, Romania.; Department of Obstetrics and Gynecology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania., Roşu GC; Department of Histology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.; Research Centre for Microscopic Morphology and Immunology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania., Drăguşin RC; Department of Obstetrics and Gynecology, University Emergency County Hospital, 200642 Craiova, Romania.; Department of Obstetrics and Gynecology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania., Berbecaru EI; Doctoral School, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania., Zorilă MV; Department of Forensic Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania., Comănescu CM; Department of Anatomy, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania., Mogoantă SȘ; General Surgery Department, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania., Vaduva CC; Department of Obstetrics and Gynecology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania., Brătilă E; Department of Obstetrics and Gynecology, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania., Iliescu DG; Department of Obstetrics and Gynecology, University Emergency County Hospital, 200642 Craiova, Romania.; Department of Obstetrics and Gynecology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.
المصدر: International journal of molecular sciences [Int J Mol Sci] 2024 Feb 01; Vol. 25 (3). Date of Electronic Publication: 2024 Feb 01.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2000-
مواضيع طبية MeSH: Endometriosis*/pathology , Adenomyosis*/pathology, Female ; Humans ; Retrospective Studies ; Epithelium/metabolism ; Tumor Suppressor Protein p53
مستخلص: Endometriosis (E) and adenomyosis (A) are associated with a wide spectrum of symptoms and may present various histopathological transformations, such as the presence of hyperplasia, atypia, and malignant transformation occurring under the influence of local inflammatory, vascular and hormonal factors and by the alteration of tumor suppressor proteins and the inhibition of cell apoptosis, with an increased degree of lesion proliferation.
Material and Methods: This retrospective study included 243 patients from whom tissue with E/A or normal control uterine tissue was harvested and stained by histochemical and classical immunohistochemical staining. We assessed the symptomatology of the patients, the structure of the ectopic epithelium and the presence of neovascularization, hormone receptors, inflammatory cells and oncoproteins involved in lesion development. Atypical areas were analyzed using multiple immunolabeling techniques.
Results: The cytokeratin (CK) CK7+/CK20- expression profile was present in E foci and differentiated them from digestive metastases. The neovascularization marker cluster of differentiation (CD) 34+ was increased, especially in areas with malignant transformation of E or A foci. T:CD3+ lymphocytes, B:CD20+ lymphocytes, CD68+ macrophages and tryptase+ mast cells were abundant, especially in cases associated with malignant transformation, being markers of the proinflammatory microenvironment. In addition, we found a significantly increased cell division index (Ki67+), with transformation and inactivation of tumor suppressor genes p53, B-cell lymphoma 2 (BCL-2) and Phosphatase and tensin homolog (PTEN) in areas with E/A-transformed malignancy.
Conclusions: Proinflammatory/vascular/hormonal changes trigger E/A progression and the onset of cellular atypia and malignant transformation, exacerbating symptoms, especially local pain and vaginal bleeding. These triggers may represent future therapeutic targets.
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معلومات مُعتمدة: 26/531/14 from 31 May 2022 University of Medicine and Pharmacy of Craiova
فهرسة مساهمة: Keywords: adenomyosis; endometriosis; multiple immunohistochemistry
المشرفين على المادة: 0 (Tumor Suppressor Protein p53)
تواريخ الأحداث: Date Created: 20240210 Date Completed: 20240214 Latest Revision: 20240214
رمز التحديث: 20240214
مُعرف محوري في PubMed: PMC10855449
DOI: 10.3390/ijms25031789
PMID: 38339066
قاعدة البيانات: MEDLINE
الوصف
تدمد:1422-0067
DOI:10.3390/ijms25031789