دورية أكاديمية
أعرض في EDS

Post-Transplant Bone Disease in Kidney Transplant Recipients: Diagnosis and Management.

التفاصيل البيبلوغرافية
العنوان: Post-Transplant Bone Disease in Kidney Transplant Recipients: Diagnosis and Management.
المؤلفون: Teh JW; Department of Nephrology, Galway University Hospital, H91 YR71 Galway, Ireland., Mac Gearailt C; Department of Rheumatology, Galway University Hospital, H91 YR71 Galway, Ireland., Lappin DWP; Department of Nephrology, Galway University Hospital, H91 YR71 Galway, Ireland.; School of Medicine, University of Galway, H91 TK33 Galway, Ireland.
المصدر: International journal of molecular sciences [Int J Mol Sci] 2024 Feb 03; Vol. 25 (3). Date of Electronic Publication: 2024 Feb 03.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2000-
مواضيع طبية MeSH: Kidney Transplantation*/adverse effects , Chronic Kidney Disease-Mineral and Bone Disorder*/diagnosis , Chronic Kidney Disease-Mineral and Bone Disorder*/etiology , Chronic Kidney Disease-Mineral and Bone Disorder*/therapy , Osteoporosis*/etiology , Fractures, Bone*/etiology , Vitamin D Deficiency*/complications, Humans ; Bone Density/physiology
مستخلص: Kidney transplantation is the preferred gold standard modality of treatment for kidney failure. Bone disease after kidney transplantation is highly prevalent in patients living with a kidney transplant and is associated with high rates of hip fractures. Fractures are associated with increased healthcare costs, morbidity and mortality. Post-transplant bone disease (PTBD) includes renal osteodystrophy, osteoporosis, osteonecrosis and bone fractures. PTBD is complex as it encompasses pre-existing chronic kidney disease-mineral bone disease and compounding factors after transplantation, including the use of immunosuppression and the development of de novo bone disease. After transplantation, the persistence of secondary and tertiary hyperparathyroidism, renal osteodystrophy, relative vitamin D deficiency and high levels of fibroblast growth factor-23 contribute to post-transplant bone disease. Risk assessment includes identifying both general risk factors and kidney-specific risk factors. Diagnosis is complex as the gold standard bone biopsy with double-tetracycline labelling to diagnose the PTBD subtype is not always readily available. Therefore, alternative diagnostic tools may be used to aid its diagnosis. Both non-pharmacological and pharmacological therapy can be employed to treat PTBD. In this review, we will discuss pathophysiology, risk assessment, diagnosis and management strategies to manage PTBD after kidney transplantation.
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فهرسة مساهمة: Keywords: chronic kidney disease–mineral bone disease; kidney failure; kidney transplantation; osteoporosis; post-transplant bone disease
تواريخ الأحداث: Date Created: 20240210 Date Completed: 20240214 Latest Revision: 20240214
رمز التحديث: 20240214
مُعرف محوري في PubMed: PMC10856017
DOI: 10.3390/ijms25031859
PMID: 38339137
قاعدة البيانات: MEDLINE
الوصف
تدمد:1422-0067
DOI:10.3390/ijms25031859