دورية أكاديمية
Supplementation with Moringa oleifera Lam leaf and seed flour during the pregnancy and lactation period of Wistar rats: Maternal evaluation of initial and adult neurobehavioral development of the rat progeny.
| العنوان: | Supplementation with Moringa oleifera Lam leaf and seed flour during the pregnancy and lactation period of Wistar rats: Maternal evaluation of initial and adult neurobehavioral development of the rat progeny. |
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| المؤلفون: | Dantas DL; Chemistry Department, Federal Rural University of Pernambuco, Zip Code: 52171-900, Recife, Pernambuco State, Brazil. Electronic address: danilold.15@gmail.com., Alves MDC; Department of Biophysics and Pharmacology, Biosciences Center, Federal University of Rio Grande do Norte, Zip Code: 59078-970, Natal, Rio Grande do Norte State, Brazil. Electronic address: alvesm.c.50@gmail.com., Dantas GMS; Chemistry Department, Organic Synthesis Laboratory, Federal University of Campina Grande, Zip Code: 58175-000, Cuité, Paraíba State, Brazil. Electronic address: gabrielmagno70@gmail.com., Campos ARN; Department of Chemical Engineering, Federal University of Campina Grande, Zip Code: 58109-970, Campina Grande, Paraíba state, Brazil. Electronic address: arncampos@yahoo.com.br., Santana RAC; Department of Mechanical Engineering, Federal University of Campina Grande, Zip Code: 58109-970, Campina Grande, Paraíba state, Brazil. Electronic address: renato_acs@yahoo.com., Soares JKB; Laboratory of Experimental Nutrition, Department of Nutrition, Federal University of Campina Grande, Zip Code: 58175-000, Cuité, Paraíba State, Brazil. Electronic address: julianakessia2@gmail.com., Freitas JCR; Chemistry Department, Organic Synthesis Laboratory, Federal University of Campina Grande, Zip Code: 58175-000, Cuité, Paraíba State, Brazil. Electronic address: julianocrf@gmail.com. |
| المصدر: | Journal of ethnopharmacology [J Ethnopharmacol] 2024 May 10; Vol. 325, pp. 117904. Date of Electronic Publication: 2024 Feb 09. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Sequoia Country of Publication: Ireland NLM ID: 7903310 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7573 (Electronic) Linking ISSN: 03788741 NLM ISO Abbreviation: J Ethnopharmacol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Limerick : Elsevier Sequoia Original Publication: Lausanne, Elsevier Sequoia. |
| مواضيع طبية MeSH: | Moringa oleifera*, Humans ; Adult ; Rats ; Pregnancy ; Female ; Animals ; Rats, Wistar ; Flour ; Plant Extracts/pharmacology ; Lactation ; Dietary Supplements ; Seeds ; Plant Leaves ; Weight Gain |
| مستخلص: | Ethnopharmacological Relevance: Moringa oleifera Lam. (M. oleifera) is a tree species of Indian origin popularly known as the "tree of life". In various cultures, it is used by pregnant women to increase milk production, yet studies on its effects during pregnancy and lactation are lacking. Aim of the Study: To evaluate the nutraceutical aspects of flours produced from the leaves and seeds of M. oleifera, and to evaluate the effect of supplementation of pregnant Wistar rats during the gestation and lactation period, with the aim of studying the weight gain and neonatal parameters of the pregnant rats, as well as effects on the neurobehavioral development and memory in their offspring. Materials and Methods: The flour supplementation was conducted at a concentration of 100 mg per kg of animal body weight. For the memory tests, the Open Field Habituation test was performed and repeated after seven days. The Object Recognition test was conducted with the animal exposed to the open field in short and long familiarization sessions. The data obtained were analyzed using Kruskal-Wallis tests for non-parametric data and one-way and two-way ANOVA for parametric data. Results: Flour produced from both the leaf and seed of M. oleifera was found to contain significant amounts of nutrients (protein, fibre, carbohydrates, etc.), making them suitable for supplementation. The exposure of pregnant rats to M. oleifera leaf and seed flours did not affect weight gain, did not have harmful effects on the birth of offspring, and did not result in abortions or mutations in the offspring. Regarding the supplemented group's offspring, early maturation of the senses in the offspring compared to the control group was observed in all tests were conducted; indicating that supplementation positively impacted cognitive development. Further, the offspring of the supplemented rats presented reduced locomotion and greater exploration of new objects compared to the control group offspring, indicating positive effects on learning. Conclusion: This study describes for the first time the beneficial effects on pregnant Wistar rats and their offspring of maternal supplementation with flour products from the leaves and seeds of M. oleifera. Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Maternal toxicity; Moringa oleifera; Neonatal parameters; Neurobehavioral parameters |
| المشرفين على المادة: | 0 (Plant Extracts) |
| تواريخ الأحداث: | Date Created: 20240211 Date Completed: 20240226 Latest Revision: 20240226 |
| رمز التحديث: | 20240226 |
| DOI: | 10.1016/j.jep.2024.117904 |
| PMID: | 38342151 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1872-7573 |
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| DOI: | 10.1016/j.jep.2024.117904 |