دورية أكاديمية
Characteristics, toxicology and major organ pathology of deaths due to acute alcohol toxicity in Australia, 2011-2022.
| العنوان: | Characteristics, toxicology and major organ pathology of deaths due to acute alcohol toxicity in Australia, 2011-2022. |
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| المؤلفون: | Darke S; National Drug & Alcohol Research Centre, UNSW Sydney, Sydney, Australia., Duflou J; National Drug & Alcohol Research Centre, UNSW Sydney, Sydney, Australia.; Sydney Medical School, The University of Sydney, Sydney, Australia., Peacock A; National Drug & Alcohol Research Centre, UNSW Sydney, Sydney, Australia., Chrzanowska A; National Drug & Alcohol Research Centre, UNSW Sydney, Sydney, Australia., Yuen WS; National Drug & Alcohol Research Centre, UNSW Sydney, Sydney, Australia., Farrell M; National Drug & Alcohol Research Centre, UNSW Sydney, Sydney, Australia., Lappin J; National Drug & Alcohol Research Centre, UNSW Sydney, Sydney, Australia.; Discipline of Psychiatry and Mental Health, UNSW Sydney, Sydney, Australia. |
| المصدر: | Drug and alcohol review [Drug Alcohol Rev] 2024 May; Vol. 43 (4), pp. 937-945. Date of Electronic Publication: 2024 Feb 12. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Blackwell Country of Publication: Australia NLM ID: 9015440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1465-3362 (Electronic) Linking ISSN: 09595236 NLM ISO Abbreviation: Drug Alcohol Rev Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: |
| مواضيع طبية MeSH: | Blood Alcohol Content*, Humans ; Male ; Female ; Middle Aged ; Retrospective Studies ; Australia/epidemiology ; Adult ; Aged ; Young Adult ; Ethanol/poisoning ; Ethanol/adverse effects ; Adolescent ; Autopsy ; Alcoholic Beverages/adverse effects ; Cause of Death/trends ; Aged, 80 and over ; Alcohol Drinking/adverse effects ; Alcohol Drinking/epidemiology ; Alcohol Drinking/trends ; Alcohol Drinking/mortality |
| مستخلص: | Introduction: Acute alcohol toxicity is a significant component of alcohol-related mortality. The study aimed to: (i) determine the circumstances of death and characteristics of fatal alcohol toxicity cases, 2011-2022; (ii) determine their toxicological profile and major autopsy findings; and (iii) determine trends in population mortality rates. Methods: Retrospective study of acute alcohol toxicity deaths in Australia, 2011-2022, retrieved from the National Coronial Information System. Results: A total of 891 cases were identified, with a mean age of 49.2 years, 71.0% being male. Alcohol use problems were noted in 71.3%. In 57.5% death was attributed solely to acute alcohol toxicity, and combined acute alcohol toxicity/disease in 42.5%. There was evidence of sudden collapse in 24.9% of cases. The mean BAC was 0.331 g/100 mL (range 0.107-0.936), and spirits were the most commonly reported beverages (35.8%). Cases of combined toxicity/disease had significantly lower BACs than those attributed solely to alcohol toxicity (0.296 vs. 0.358 g/100 mL). Cardiomegaly was diagnosed in 32.5%, and severe coronary artery disease in 22.1%. Aspiration of vomitus was noted in 18.0%, and chronic obstructive pulmonary disease in 19.6%. Severe liver steatosis was present in 33.4% and 13.6% had cirrhosis. There was an average annual percentage increase in deaths of 7.90. Discussion and Conclusions: The 'typical' case was a long-standing, heavy spirits drinker. BACs showed enormous variation and no arbitrary concentration may be deemed lethal. Clinically significant disease was associated with death at a lower BAC and people with such disease may be at increased risk of alcohol poisoning. (© 2024 Australasian Professional Society on Alcohol and other Drugs.) |
| References: | Griswold MG, Fullman N, Hawley C, Arian N, Zimsen SR, Tymeson HD, et al. Alcohol use and burden for 195 countries and territories, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet. 2018;392:1015–1035. Minzer S, Losno RA, Casas R. The effect of alcohol on cardiovascular risk factors: is there new information? Nutrients. 2020;12:912. US Department of Health and Human Services. 10th special report to the US congress on alcohol and health. Bethesda, MD: National Institute on Alcohol Abuse and Alcoholism; 2000. Connor J. Alcohol consumption as a cause of cancer. Addiction. 2017;112:222–228. Below E, Lignitz E. Cases of poisoning in post‐mortem examinations at the Institute of Forensic Medicine in Greifswald—analysis of five decades of post‐mortems. Forensic Sci Int. 2003;133:125–131. Darke S, Duflou J, Torok M, Prolov T. Characteristics, circumstances and toxicology of sudden or unnatural deaths involving very high range alcohol concentrations. Addiction. 2013;108:1411–1417. White AM, Castle IJ, Hingson RW, Powell PA. Using death certificates to explore changes in alcohol‐related mortality in the United States, 1999 to 2017. Alcohol Clin Exp Res. 2020;44:178–187. Zaridze D, Maximovitch D, Lazarev A, Igitov V, Boroda A, Boreham J, et al. Alcohol poisoning is a main determinant of recent mortality trends in Russia: evidence from a detailed analysis of mortality statistics and autopsies. Int J Epidemiol. 2009;38:143–153. Morley SR, Smith P, Johnson C. Acute alcohol toxicity. Acad Forensic Pathol. 2014;4:161–167. Celik S, Karapirli M, Kandemir E, Ucar F, Kantarcı MN, Gurler M, et al. Fatal ethyl and methyl alcohol‐related poisoning in Ankara: a retrospective analysis of 10,720 cases between 2001 and 2011. J Forensic Leg Med. 2013;20:151–154. Darke S, Duflou J, Torok M, Prolov T. Toxicology, circumstances and pathology of deaths from acute alcohol toxicity. J Forensic Leg Med. 2013;20:1122–1125. Heatley MK, Crane J. The blood alcohol concentration at post‐mortem in 175 fatal cases of alcohol intoxication. Med Sci Law. 1990;30:101–105. Jones AW, Holmgren P. Comparison of blood‐ethanol concentration in deaths attributed to acute alcohol poisoning and chronic alcoholism. J Forensic Sci. 2003;48:874–879. Jones AW, Holmgren P. Concentration distributions of the drugs most frequently identified in post‐mortem femoral blood representing all causes of death. Med Sci Law. 2009;49:257–273. Jones AW, Kugelberg FC, Holmgren A, Ahlner J. Drug poisoning deaths in Sweden show a predominance of ethanol in mono‐intoxications, adverse drug–alcohol interactions and poly‐drug use. Forensic Sci Int. 2011;206:43–51. Kriikku P, Ojanperä I. Significant decrease in the rate of fatal alcohol poisonings in Finland validated by blood alcohol concentration statistics. Drug Alcohol Depend. 2020;206:107722. Nordrum I, Eide TJ, Jørgensen L. Alcohol in a series of medico‐legally autopsied deaths in northern Norway 1973–1992. Forensic Sci Int. 2000;110:127–137. Sjögren H, Eriksson A, Ahlm K. Role of alcohol in unnatural deaths: a study of all deaths in Sweden. Alcohol Clin Exp Res. 2000;24:1050–1056. Wang H, Xu H, Li W, Li B, Shi Q, Ma K, et al. Forensic appraisal of death due to acute alcohol poisoning: three case reports and a literature review. Forensic Sci Res. 2020;5:341–347. Berild D, Hasselbalch H. Survival after a blood alcohol of 1127 mg/dL. Lancet. 1981;2:363. Johnson RA, Noll EC, Rodney WM. Survival after serum ethanol concentration of 1.5%. Lancet. 1982;12:1394. Kitzman DW, Scholz DG, Hagen PT, Ilstrup DM, Edwards WD. Age‐related changes in normal human hearts during the first 10 decades of life. Part II (maturity), a quantitative anatomic study of 765 specimens from subjects 20 to 99 years old. Mayo Clin Proc. 1988;63:137–146. Scholz DG, Kitzman DW, Hagen PT, Ilstrup DM, Edwards WD. Age‐related changes in normal human hearts during the first 10 decades of life. Part I (growth), a quantitative anatomic study of 200 specimens from subjects from birth to 19 years old. Mayo Clin Proc. 1988;63:126–136. IBM Inc. spss for Windows, 27.0. Chicago, IL: SPSS Inc; 2021. Australian Bureau of Statistics. National, state and territory population. Canberra: Australian Bureau of Statistics. Canberra: Australian Bureau of Statistics; 2022. National Cancer Institute. Joinpoint Regression Program, version 5.0.2. NJ: Statistical Research and Applications Branch, National Cancer Institute; 2023. Razvodovsky YE. Beverage‐specific alcohol sale and cardiovascular mortality in Russia. J Environ Pub Health. 2010;2010:253853. Drummer OH. Alcohol: pharmacology and disposition. Acad Forensic Pathol. 2014;4:128–137. Hufnagel A, Frick U, Ridinger M, Wodarz N. Recovery from alcohol dependence: do smoking indicators predict abstinence? Am J Addict. 2017;26:366–373. Foundation for Alcohol Research & Education. Alcohol‐induced deaths in Australia. Canberra: Australian Bureau of Statistics; 2023. Eastwood B, Peacock A, Millar T, Jones A, Knight J, Horgan P, et al. Effectiveness of inpatient withdrawal and residential rehabilitation interventions for alcohol use disorder: a national observational, cohort study in England. J Subst Abuse Treat. 2018;88:1–8. Mutschler C, Junaid S, Tellez C, Franco G, Gryspeerdt C, Bushe J. Community‐based residential treatment for alcohol and substance use problems: a realist review. Health Soc Care Community. 2022;30:287–304. Peacock A, Eastwood B, Jones A, Millar T, Horgan P, Knight J, et al. Effectiveness of community psychosocial and pharmacological treatments for alcohol use disorder: a national observational cohort study in England. Drug Alcohol Depend. 2018;186:60–67. Tolomeo S, Baldacchino A. Adherence to prescribed acamprosate in alcohol dependence and 1‐year morbidities and mortality: utilizing a data linkage methodology. J Clin Med. 2021;10:2102. |
| معلومات مُعتمدة: | National Drug and Alcohol Research Centre |
| فهرسة مساهمة: | Keywords: alcohol; circumstance; disease; mortality; toxicology |
| المشرفين على المادة: | 0 (Blood Alcohol Content) 3K9958V90M (Ethanol) |
| تواريخ الأحداث: | Date Created: 20240212 Date Completed: 20240426 Latest Revision: 20240426 |
| رمز التحديث: | 20240426 |
| DOI: | 10.1111/dar.13817 |
| PMID: | 38345860 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1465-3362 |
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| DOI: | 10.1111/dar.13817 |