دورية أكاديمية
Characteristics, toxicology and major organ pathology of deaths due to acute alcohol toxicity in Australia, 2011-2022.
العنوان: | Characteristics, toxicology and major organ pathology of deaths due to acute alcohol toxicity in Australia, 2011-2022. |
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المؤلفون: | Darke S; National Drug & Alcohol Research Centre, UNSW Sydney, Sydney, Australia., Duflou J; National Drug & Alcohol Research Centre, UNSW Sydney, Sydney, Australia.; Sydney Medical School, The University of Sydney, Sydney, Australia., Peacock A; National Drug & Alcohol Research Centre, UNSW Sydney, Sydney, Australia., Chrzanowska A; National Drug & Alcohol Research Centre, UNSW Sydney, Sydney, Australia., Yuen WS; National Drug & Alcohol Research Centre, UNSW Sydney, Sydney, Australia., Farrell M; National Drug & Alcohol Research Centre, UNSW Sydney, Sydney, Australia., Lappin J; National Drug & Alcohol Research Centre, UNSW Sydney, Sydney, Australia.; Discipline of Psychiatry and Mental Health, UNSW Sydney, Sydney, Australia. |
المصدر: | Drug and alcohol review [Drug Alcohol Rev] 2024 May; Vol. 43 (4), pp. 937-945. Date of Electronic Publication: 2024 Feb 12. |
نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Wiley-Blackwell Country of Publication: Australia NLM ID: 9015440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1465-3362 (Electronic) Linking ISSN: 09595236 NLM ISO Abbreviation: Drug Alcohol Rev Subsets: MEDLINE |
أسماء مطبوعة: | Publication: |
مواضيع طبية MeSH: | Blood Alcohol Content*, Humans ; Male ; Female ; Middle Aged ; Retrospective Studies ; Australia/epidemiology ; Adult ; Aged ; Young Adult ; Ethanol/poisoning ; Ethanol/adverse effects ; Adolescent ; Autopsy ; Alcoholic Beverages/adverse effects ; Cause of Death/trends ; Aged, 80 and over ; Alcohol Drinking/adverse effects ; Alcohol Drinking/epidemiology ; Alcohol Drinking/trends ; Alcohol Drinking/mortality |
مستخلص: | Introduction: Acute alcohol toxicity is a significant component of alcohol-related mortality. The study aimed to: (i) determine the circumstances of death and characteristics of fatal alcohol toxicity cases, 2011-2022; (ii) determine their toxicological profile and major autopsy findings; and (iii) determine trends in population mortality rates. Methods: Retrospective study of acute alcohol toxicity deaths in Australia, 2011-2022, retrieved from the National Coronial Information System. Results: A total of 891 cases were identified, with a mean age of 49.2 years, 71.0% being male. Alcohol use problems were noted in 71.3%. In 57.5% death was attributed solely to acute alcohol toxicity, and combined acute alcohol toxicity/disease in 42.5%. There was evidence of sudden collapse in 24.9% of cases. The mean BAC was 0.331 g/100 mL (range 0.107-0.936), and spirits were the most commonly reported beverages (35.8%). Cases of combined toxicity/disease had significantly lower BACs than those attributed solely to alcohol toxicity (0.296 vs. 0.358 g/100 mL). Cardiomegaly was diagnosed in 32.5%, and severe coronary artery disease in 22.1%. Aspiration of vomitus was noted in 18.0%, and chronic obstructive pulmonary disease in 19.6%. Severe liver steatosis was present in 33.4% and 13.6% had cirrhosis. There was an average annual percentage increase in deaths of 7.90. Discussion and Conclusions: The 'typical' case was a long-standing, heavy spirits drinker. BACs showed enormous variation and no arbitrary concentration may be deemed lethal. Clinically significant disease was associated with death at a lower BAC and people with such disease may be at increased risk of alcohol poisoning. (© 2024 Australasian Professional Society on Alcohol and other Drugs.) |
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معلومات مُعتمدة: | National Drug and Alcohol Research Centre |
فهرسة مساهمة: | Keywords: alcohol; circumstance; disease; mortality; toxicology |
المشرفين على المادة: | 0 (Blood Alcohol Content) 3K9958V90M (Ethanol) |
تواريخ الأحداث: | Date Created: 20240212 Date Completed: 20240426 Latest Revision: 20240426 |
رمز التحديث: | 20240426 |
DOI: | 10.1111/dar.13817 |
PMID: | 38345860 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1465-3362 |
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DOI: | 10.1111/dar.13817 |