دورية أكاديمية
Airway smooth muscle and long-term clinical efficacy following bronchial thermoplasty in severe asthma.
| العنوان: | Airway smooth muscle and long-term clinical efficacy following bronchial thermoplasty in severe asthma. |
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| المؤلفون: | Wijsman PC; Department of Pulmonary Medicine, Amsterdam UMC Locatie AMC, Amsterdam, The Netherlands., Goorsenberg AWM; Department of Pulmonary Medicine, Amsterdam UMC Locatie AMC, Amsterdam, The Netherlands., d'Hooghe JNS; Department of Pulmonary Medicine, Amsterdam UMC Locatie AMC, Amsterdam, The Netherlands., Ten Hacken NHT; Department of Pulmonology, University of Groningen, Groningen, The Netherlands., J T H Roelofs J; Pathology, Amsterdam UMC Locatie AMC, Amsterdam, The Netherlands., Mauad T; Pathology, São Paulo University Medical School, São Paulo, Brazil., Weersink EJM; Department of Pulmonary Medicine, Amsterdam UMC Locatie AMC, Amsterdam, The Netherlands., Shah P; Lung Unit, Royal Brompton and Harefield NHS Foundation and Imperial College, London, UK.; Lung Unit, Chelsea and Westminster Hospital NHS Foundation Trust, London, UK., Annema JT; Department of Pulmonary Medicine, Amsterdam UMC Locatie AMC, Amsterdam, The Netherlands., Bonta PI; Department of Pulmonary Medicine, Amsterdam UMC Locatie AMC, Amsterdam, The Netherlands p.i.bonta@amsterdamumc.nl. |
| المصدر: | Thorax [Thorax] 2024 Mar 15; Vol. 79 (4), pp. 359-362. Date of Electronic Publication: 2024 Mar 15. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: British Medical Assn Country of Publication: England NLM ID: 0417353 Publication Model: Electronic Cited Medium: Internet ISSN: 1468-3296 (Electronic) Linking ISSN: 00406376 NLM ISO Abbreviation: Thorax Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: London : British Medical Assn. |
| مواضيع طبية MeSH: | Bronchial Thermoplasty* , Asthma*/drug therapy, Humans ; Bronchi/surgery ; Quality of Life ; Desmin/therapeutic use ; Treatment Outcome ; Muscle, Smooth |
| مستخلص: | The mechanism of action of bronchial thermoplasty (BT) treatment for patients with severe asthma is incompletely understood. This study investigated the 2.5-year impact of BT on airway smooth muscle (ASM) mass and clinical parameters by paired data analysis in 22 patients. Our findings demonstrate the persistence of ASM mass reduction of >50% after 2.5 years. Furthermore, sustained improvement in asthma control, quality of life and exacerbation rates was found, which is in line with previous reports. An association was found between the remaining ASM and both the exacerbation rate (r=0.61, p=0.04 for desmin, r=0.85, p<0.01 for alpha smooth muscle actin (SMA)) and post-bronchodilator forced expiratory volume in 1 s predicted percentage (r=-0.69, p=0.03 for desmin, r=-0.58, p=0.08 for alpha SMA). This study provides new insight into the long-term impact of BT. Competing Interests: Competing interests: No conflicts of interest exist for the following authors—PW, AWMG, JNSd'H, NHTtH, JJTHR, TM, EJMW and PS. JTA reports research grants from Boston Scientific during the conduct of the study. PB reports research grants from Boston Scientific, non-financial support from Boston Scientific related to investigator-initiated research grant, research grants from ZonMw and research grants from Dutch Lung Foundation, during the conduct of the study. (© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.) |
| References: | Respir Res. 2021 Jun 28;22(1):186. (PMID: 34183014) J Allergy Clin Immunol. 2021 Nov;148(5):1227-1235.e6. (PMID: 33453288) ERJ Open Res. 2023 Jul 03;9(4):. (PMID: 37404844) J Allergy Clin Immunol. 2017 Apr;139(4):1176-1185. (PMID: 27609656) Am J Respir Crit Care Med. 2021 Jan 15;203(2):175-184. (PMID: 32721210) Ann Am Thorac Soc. 2016 Aug;13(8):1426-8. (PMID: 27509158) Respir Med. 2019 Apr;150:165-172. (PMID: 30961946) Lancet Respir Med. 2021 May;9(5):457-466. (PMID: 33524320) Respir Med. 2023 Oct;217:107340. (PMID: 37422022) Chest. 2021 Aug;160(2):432-435. (PMID: 33785301) Eur Respir J. 2021 Dec 31;59(1):. (PMID: 34049950) |
| فهرسة مساهمة: | Keywords: Asthma |
| المشرفين على المادة: | 0 (Desmin) |
| تواريخ الأحداث: | Date Created: 20240212 Date Completed: 20240318 Latest Revision: 20240324 |
| رمز التحديث: | 20240324 |
| مُعرف محوري في PubMed: | PMC10958325 |
| DOI: | 10.1136/thorax-2023-220967 |
| PMID: | 38346871 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1468-3296 |
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| DOI: | 10.1136/thorax-2023-220967 |