دورية أكاديمية
Radiological characteristics predicting early poor drug response in patients with hemifacial spasm.
| العنوان: | Radiological characteristics predicting early poor drug response in patients with hemifacial spasm. |
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| المؤلفون: | Li B; Department of Radiology, The First People's Hospital of Foshan, Foshan, 528000, Guangdong Province, China.; Sun Yat-Sen University, Guangzhou, 510080, Guangdong Province, China., Huang L; Department of Radiology, The First People's Hospital of Foshan, Foshan, 528000, Guangdong Province, China., Luo C; Department of Radiology, The First People's Hospital of Foshan, Foshan, 528000, Guangdong Province, China., Jin Y; Institute of Translational Medicine, The First People's Hospital of Foshan, Foshan, 528000, Guangdong Province, China., Zhong X; Department of Functional Neurosurgery, The First People's Hospital of Foshan, Foshan, 528000, Guangdong Province, China., Wang G; Department of Functional Neurosurgery, The First People's Hospital of Foshan, Foshan, 528000, Guangdong Province, China., Xu Z; Department of Radiology, The First People's Hospital of Foshan, Foshan, 528000, Guangdong Province, China., Chen J; Department of Radiology, The First People's Hospital of Foshan, Foshan, 528000, Guangdong Province, China., Huang S; Department of Radiology, The First People's Hospital of Foshan, Foshan, 528000, Guangdong Province, China., Zhao H; Department of Radiology, The First People's Hospital of Foshan, Foshan, 528000, Guangdong Province, China. 13760988108@163.com., Gao M; Department of Radiology, The First People's Hospital of Foshan, Foshan, 528000, Guangdong Province, China. gmyong163@163.com. |
| المصدر: | Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology [Neurol Sci] 2024 Jul; Vol. 45 (7), pp. 3217-3224. Date of Electronic Publication: 2024 Feb 13. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer-Verlag Italia Country of Publication: Italy NLM ID: 100959175 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1590-3478 (Electronic) Linking ISSN: 15901874 NLM ISO Abbreviation: Neurol Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Milano, Italy : Springer-Verlag Italia, c2000- |
| مواضيع طبية MeSH: | Hemifacial Spasm*/drug therapy , Hemifacial Spasm*/diagnostic imaging , Hemifacial Spasm*/surgery , Magnetic Resonance Imaging*, Humans ; Male ; Female ; Middle Aged ; Retrospective Studies ; Aged ; Adult ; Neuromuscular Agents/administration & dosage ; Neuromuscular Agents/therapeutic use ; Treatment Outcome ; Facial Nerve/diagnostic imaging ; Facial Nerve/physiopathology |
| مستخلص: | Objectives: Patients with hemifacial spasm (HFS) often resort to botulinum toxin injections or microvascular decompression surgery when medication exhibits limited effectiveness. This study aimed to identify MRI and demographic factors associated with poor drug response at an early stage in patients with HFS. Methods: We retrospectively included patients with HFS who underwent pre-therapeutic MRI examination. The presence, location, severity, and the offending vessels of neurovascular compression were blindly evaluated using MRI. Drug responses and clinical data were obtained from the medical notes or phone follow-ups. Logistic regression analysis was performed to identify potential factors. Results: A total of 116 patients were included, with an average age at the time of first examination of 50.4 years and a median duration of onset of 18 months. Forty-nine (42.2%) patients reported no symptom relief. Thirty-seven (31.9%) patients reported poor symptom relief. Twenty-two (19.0%) patients reported partial symptom relief. Eight (6.9%) patients achieved complete symptom relief. The factors that were statistically significant associated with poor drug responses were contact in the attach segment of the facial nerve and aged 70 and above, with an odds ratio of 7.772 (p = 0.002) and 0.160 (p = 0.028), respectively. Conclusions: This study revealed that mild compression in the attach segment of the facial nerve in pre-therapeutic MRI increases the risk of poor drug responses in patients with HFS, while patients aged 70 and above showed a decreased risk. These findings may assist clinician to choose optimal treatment at an early stage. (© 2024. Fondazione Società Italiana di Neurologia.) |
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| معلومات مُعتمدة: | FSGSP145036 the Foshan 14th Five-Year Plan Key Discipline Foundation |
| فهرسة مساهمة: | Keywords: Carbamazepine; Hemifacial spasm; MRI; Neurovascular compression; Predictive factors |
| المشرفين على المادة: | 0 (Neuromuscular Agents) |
| تواريخ الأحداث: | Date Created: 20240212 Date Completed: 20240614 Latest Revision: 20240614 |
| رمز التحديث: | 20240614 |
| DOI: | 10.1007/s10072-024-07389-9 |
| PMID: | 38347297 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1590-3478 |
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| DOI: | 10.1007/s10072-024-07389-9 |