دورية أكاديمية
أعرض في EDS

The Index sAGP is Valuable for Distinguishing Atypical Hepatocellular Carcinoma from Atypical Benign Focal Hepatic Lesions.

التفاصيل البيبلوغرافية
العنوان: The Index sAGP is Valuable for Distinguishing Atypical Hepatocellular Carcinoma from Atypical Benign Focal Hepatic Lesions.
المؤلفون: Luo QQ; Department of Gastroenterology, the First Affiliated Hospital of Nanchang University, Jiangxi Institute of Gastroenterology & Hepatology, Nanchang, People's Republic of China., Li QN; Department of Gastroenterology, the First Affiliated Hospital of Nanchang University, Jiangxi Institute of Gastroenterology & Hepatology, Nanchang, People's Republic of China., Cai D; Department of Gastroenterology, the First Affiliated Hospital of Nanchang University, Jiangxi Institute of Gastroenterology & Hepatology, Nanchang, People's Republic of China., Jiang S; Department of Gastroenterology, the First Affiliated Hospital of Nanchang University, Jiangxi Institute of Gastroenterology & Hepatology, Nanchang, People's Republic of China., Liu SS; Department of Gastroenterology, the First Affiliated Hospital of Nanchang University, Jiangxi Institute of Gastroenterology & Hepatology, Nanchang, People's Republic of China., Liu MS; Department of Gastroenterology, the First Affiliated Hospital of Nanchang University, Jiangxi Institute of Gastroenterology & Hepatology, Nanchang, People's Republic of China., Lv C; Department of Gastroenterology, the First Affiliated Hospital of Nanchang University, Jiangxi Institute of Gastroenterology & Hepatology, Nanchang, People's Republic of China., Wang JK; Department of Gastroenterology, the First Affiliated Hospital of Nanchang University, Jiangxi Institute of Gastroenterology & Hepatology, Nanchang, People's Republic of China., Zhang KH; Department of Gastroenterology, the First Affiliated Hospital of Nanchang University, Jiangxi Institute of Gastroenterology & Hepatology, Nanchang, People's Republic of China., Wang T; Department of Gastroenterology, the First Affiliated Hospital of Nanchang University, Jiangxi Institute of Gastroenterology & Hepatology, Nanchang, People's Republic of China.
المصدر: Journal of hepatocellular carcinoma [J Hepatocell Carcinoma] 2024 Feb 08; Vol. 11, pp. 317-325. Date of Electronic Publication: 2024 Feb 08 (Print Publication: 2024).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Dove Press Country of Publication: New Zealand NLM ID: 101674775 Publication Model: eCollection Cited Medium: Print ISSN: 2253-5969 (Print) Linking ISSN: 22535969 NLM ISO Abbreviation: J Hepatocell Carcinoma Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [Auckland, New Zealand] : Dove Press, [2014]-
مستخلص: Purpose: The differential diagnosis of atypical hepatocellular carcinoma (aHCC) and atypical benign focal hepatic lesions (aBFHL) usually depends on pathology. This study aimed to develop non-invasive approaches based on conventional blood indicators for the differential diagnosis of aHCC and aBFHL.
Patients and Methods: Hospitalized patients with pathologically confirmed focal hepatic lesions and their clinical data were retrospectively collected, in which patients with HCC with serum alpha-fetoprotein (AFP) levels of ≤200 ng/mL and atypical imaging features were designated as the aHCC group (n = 224), and patients with benign focal hepatic lesions without typical imaging features were designated as the aBFHL group (n = 178). The performance of indexes (both previously reported and newly constructed) derived from conventional blood indicators by four mathematical operations in distinguishing aHCC and aBFHL was evaluated using the receiver operating characteristic (ROC) curve and diagnostic validity metrics.
Results: Among ten previously reported derived indexes related to HCC, the index GPR, the ratio of γ-glutamyltransferase (GGT) to platelet (PLT), showed the best performance in distinguishing aHCC from aBFHL with the area under ROC curve (AUROC) of 0.853 (95% CI 0.814-0.892), but the other indexes were of little value (AUROCs from 0.531 to 0.700). A new derived index, sAGP [(standardized AFP + standardized GGT)/standardized PLT], was developed and exhibited AUROCs of 0.905, 0.894, 0.891, 0.925, and 0.862 in differentiating overall, BCLC stage 0/A, TNM stage I, small, and AFP-negative aHCC from aBFHL, respectively.
Conclusion: The sAGP index is an efficient, simple, and practical metric for the non-invasive differentiation of aHCC from aBFHL.
Competing Interests: The authors report no conflicts of interest in this work.
(© 2024 Luo et al.)
References: Sci Rep. 2020 Aug 11;10(1):13519. (PMID: 32782270)
Gastroenterology. 2010 Feb;138(2):493-502. (PMID: 19852963)
Pathol Oncol Res. 2020 Jul;26(3):1669-1676. (PMID: 31578661)
J Gastroenterol Hepatol. 2017 Jun;32(6):1221-1229. (PMID: 27859587)
J Immunol Res. 2018 May 22;2018:4925498. (PMID: 30027102)
Int J Oncol. 2015 Aug;47(2):543-54. (PMID: 26058824)
Hepatol Int. 2017 Jul;11(4):317-370. (PMID: 28620797)
World J Gastroenterol. 2015 Oct 7;21(37):10573-83. (PMID: 26457017)
J Hepatol. 2022 Mar;76(3):681-693. (PMID: 34801630)
World J Gastroenterol. 2017 May 14;23(18):3228-3239. (PMID: 28566882)
Front Oncol. 2021 Mar 26;11:544979. (PMID: 33842303)
Cancer Cell Int. 2020 Mar 12;20:77. (PMID: 32190001)
Hepatol Int. 2022 Dec;16(6):1353-1367. (PMID: 36169915)
Clin Res Hepatol Gastroenterol. 2021 Sep;45(5):101509. (PMID: 33744828)
Cancer Biol Med. 2021 Feb 15;18(1):256-270. (PMID: 33628599)
J Hepatol. 2001 Apr;34(4):570-5. (PMID: 11394657)
Clin Res Hepatol Gastroenterol. 2022 Dec;46(10):102043. (PMID: 36307017)
Protoplasma. 2017 Mar;254(2):911-920. (PMID: 27525410)
Transl Cancer Res. 2021 Jun;10(6):2985-2990. (PMID: 35116606)
Liver Int. 2020 Jan;40(1):229-239. (PMID: 31652394)
APMIS. 2016 Sep;124(9):776-86. (PMID: 27457354)
CA Cancer J Clin. 2021 May;71(3):209-249. (PMID: 33538338)
Br J Cancer. 2021 Aug;125(5):714-716. (PMID: 34127809)
Radiology. 2015 Jun;275(3):870-9. (PMID: 25584708)
Cancer Med. 2021 Jul;10(14):4844-4854. (PMID: 34145988)
Front Oncol. 2020 Oct 16;10:576205. (PMID: 33178607)
IEEE J Biomed Health Inform. 2020 Oct;24(10):2860-2869. (PMID: 32149699)
Biosci Rep. 2018 Nov 28;38(6):. (PMID: 30389711)
فهرسة مساهمة: Keywords: atypical hepatocellular carcinoma; conventional blood indicator; derived index; differential diagnosis; sAGP
تواريخ الأحداث: Date Created: 20240213 Latest Revision: 20240214
رمز التحديث: 20240214
مُعرف محوري في PubMed: PMC10860805
DOI: 10.2147/JHC.S443273
PMID: 38348099
قاعدة البيانات: MEDLINE
الوصف
تدمد:2253-5969
DOI:10.2147/JHC.S443273