دورية أكاديمية
Polymorphisms in drug-metabolizing genes and urinary bladder cancer susceptibility and prognosis: Possible impacts and future management.
| العنوان: | Polymorphisms in drug-metabolizing genes and urinary bladder cancer susceptibility and prognosis: Possible impacts and future management. |
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| المؤلفون: | Silva IMD; Department of General Biology, Center of Biological Sciences, State University of Londrina (UEL), Londrina 86057-970, Brazil. Electronic address: isabely.silva20@uel.br., Vacario BGL; Department of General Biology, Center of Biological Sciences, State University of Londrina (UEL), Londrina 86057-970, Brazil; Center of Health Sciences, State University of West Paraná (UNIOESTE), Francisco Beltrão-Paraná, 85605-010, Brazil. Electronic address: beatriz.geovana@uel.br., Okuyama NCM; Department of General Biology, Center of Biological Sciences, State University of Londrina (UEL), Londrina 86057-970, Brazil. Electronic address: nadia.cmokuyama@uel.br., Barcelos GRM; Department of Biosciences, Institute for Health and Society, Federal University of São Paulo (UNIFESP), Santos 11.060-001, Brazil. Electronic address: gustavo.barcelos@unifesp.br., Fuganti PE; Londrina Cancer Hospital, Urology, Londrina, Paraná 86015-520, Brazil. Electronic address: paulo10urologia@hotmail.com., Guembarovski RL; Department of General Biology, Center of Biological Sciences, State University of Londrina (UEL), Londrina 86057-970, Brazil. Electronic address: robertalosi@uel.br., Cólus IMS; Department of General Biology, Center of Biological Sciences, State University of Londrina (UEL), Londrina 86057-970, Brazil. Electronic address: colus@uel.br., Serpeloni JM; Department of General Biology, Center of Biological Sciences, State University of Londrina (UEL), Londrina 86057-970, Brazil. Electronic address: julianaserpeloni@uel.br. |
| المصدر: | Gene [Gene] 2024 May 20; Vol. 907, pp. 148252. Date of Electronic Publication: 2024 Feb 11. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier/North-Holland Country of Publication: Netherlands NLM ID: 7706761 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0038 (Electronic) Linking ISSN: 03781119 NLM ISO Abbreviation: Gene Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam, Elsevier/North-Holland, 1976- |
| مواضيع طبية MeSH: | Urinary Bladder Neoplasms*/genetics , Arylamine N-Acetyltransferase*/genetics, Humans ; Glutathione Transferase/genetics ; Polymorphism, Genetic ; Cytochrome P-450 CYP1A1/genetics ; Cytochrome P-450 CYP2D6/genetics ; Genetic Predisposition to Disease ; Genotype ; Case-Control Studies ; Risk Factors ; Aldehyde Dehydrogenase, Mitochondrial/genetics |
| مستخلص: | Epidemiological studies have shown the association of genetic variants with risks of occupational and environmentally induced cancers, including bladder (BC). The current review summarizes the effects of variants in genes encoding phase I and II enzymes in well-designed studies to highlight their contribution to BC susceptibility and prognosis. Polymorphisms in genes codifying drug-metabolizing proteins are of particular interest because of their involvement in the metabolism of exogenous genotoxic compounds, such as tobacco and agrochemicals. The prognosis between muscle-invasive and non-muscle-invasive diseases is very different, and it is difficult to predict which will progress worse. Web of Science, PubMed, and Medline were searched to identify studies published between January 1, 2010, and February 2023. We included 73 eligible studies, more than 300 polymorphisms, and 46 genes/loci. The most studied candidate genes/loci of phase I metabolism were CYP1B1, CYP1A1, CYP1A2, CYP3A4, CYP2D6, CYP2A6, CYP3E1, and ALDH2, and those in phase II were GSTM1, GSTT1, NAT2, GSTP1, GSTA1, GSTO1, and UGT1A1. We used the 46 genes to construct a network of proteins and to evaluate their biological functions based on the Reactome and KEGG databases. Lastly, we assessed their expression in different tissues, including normal bladder and BC samples. The drug-metabolizing pathway plays a relevant role in BC, and our review discusses a list of genes that could provide clues for further exploration of susceptibility and prognostic biomarkers. Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Biometabolism; Bladder cancer; Genetic variant; Indels; SNPs; Urothelial cancer |
| المشرفين على المادة: | EC 2.5.1.18 (Glutathione Transferase) EC 1.14.14.1 (Cytochrome P-450 CYP1A1) EC 1.14.14.1 (Cytochrome P-450 CYP2D6) EC 2.3.1.5 (NAT2 protein, human) EC 2.3.1.5 (Arylamine N-Acetyltransferase) EC 1.2.1.3 (ALDH2 protein, human) EC 1.2.1.3 (Aldehyde Dehydrogenase, Mitochondrial) EC 2.5.1.18 (GSTO1 protein, human) |
| تواريخ الأحداث: | Date Created: 20240213 Date Completed: 20240313 Latest Revision: 20240313 |
| رمز التحديث: | 20240313 |
| DOI: | 10.1016/j.gene.2024.148252 |
| PMID: | 38350514 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1879-0038 |
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| DOI: | 10.1016/j.gene.2024.148252 |